Dr Matthew Siggins is a senior postdoctoral researcher working within Professor Peter Openshaw's group in the Department of Respiratory Medicine of the National Heart and Lung Institute. Matthew's work centres on infection, immunity, and immune dysfunction, with a focus on the lymphatic system.
Currently, as part of ISARIC4C, he is analysing immune responses in COVID-19 patients to understand the immunology of disease, consequences of infection, and potential therapeutics.
Prior to this, he demonstrated how extracellular bacteria, including Streptococcus pyogenes, can move through lymph nodes to drive systemic infection (Nature Communications: 4697).
Matthew is also funded as lead investigator on an Imperial Confidence in Concept (MRC/BBSRC/Yuhan) grant, working with Professor Shiranee Sriskandan, to research lymph node targeting vaccine vectors.
et al., 2021, Commensal bacteria augment Staphylococcus aureus infection by inactivation of phagocyte-derived reactive oxygen species., Plos Pathog, Vol:17
Siggins MK, Thwaites RS, Openshaw PJM, 2021, Durability of immunity to SARS-CoV-2 and other respiratory viruses: (Trends in microbiology, 29, 648-662, 2021)., Trends in Microbiology, ISSN:0966-842X
Siggins MK, Thwaites RS, Openshaw PJM, 2021, Durability of Immunity to SARS-CoV-2 and Other Respiratory Viruses, Trends in Microbiology, Vol:29, ISSN:0966-842X, Pages:648-662
et al., 2021, Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19, Science Immunology, Vol:6, ISSN:2470-9468, Pages:1-17
et al., 2020, PD-1 blockade improves Kupffer cell bacterial clearance in acute liver injury, Journal of Clinical Investigation, Vol:131, ISSN:0021-9738, Pages:1-16