Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Research Fellow



m.siggins Website




345Norfolk PlaceSt Mary's Campus





Fluorescent imaging of flank vasculature that connects lymph nodes

Dr Matthew Siggins is a Research Fellow working with Professor Peter Openshaw's group in the National Heart and Lung Institute. Matthew's research centres on infection, immunity, vaccinology, and immune dysfunction, with a focus on pathogen dissemination within the lymphatic system.

Matthew is an Early Career Trustee for the British Society for Immunology and a member of the NHLI Postdoc and Fellows Committee.

Currently, as part of ISARIC4C and PHOSP-COVID, Dr Siggins is analysing immune responses in large datasets of COVID-19 patients using machine learning to understand the immunology of disease, consequences of infection, as well as potential diagnostics and therapeutics.

Prior to this, he demonstrated how extracellular bacteria, including Streptococcus pyogenes, can move through lymph nodes to drive systemic infection; work that was published in Nature Communications. This lymphatic research is the focus of Dr Siggins's NHLI Research Fellowship.

Dr Siggins is also funded as lead investigator on an Imperial Confidence in Concept (UKRI/Yuhan) grant, working with Professor Shiranee Sriskandan, to research lymph node targeting vaccine vectors.

Selected Publications

Journal Articles

Siggins MK, Thwaites RS, Openshaw PJM, 2021, Durability of immunity to SARS-CoV-2 and other respiratory viruses, Trends in Microbiology, Vol:29, ISSN:0966-842X, Pages:648-662

Siggins MK, Lynskey NN, Lamb L, et al., 2020, Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection, Nature Communications, Vol:11, ISSN:2041-1723

More Publications