Dr Matthew Siggins is a senior postdoctoral researcher working within Professor Peter Openshaw's group in the National Heart and Lung Institute. Matthew's work centres on infection, immunity, and immune dysfunction, with a focus on the lymphatic system.
Currently, as part of ISARIC4C, he is analysing immune responses in COVID-19 patients to understand the immunology of disease, consequences of infection, and potential therapeutics.
Prior to this, he demonstrated how extracellular bacteria, including Streptococcus pyogenes, can move through lymph nodes to drive systemic infection (Nature Communications: 4697).
Matthew is also funded as lead investigator on an Imperial Confidence in Concept (MRC/BBSRC/Yuhan) grant, working with Professor Shiranee Sriskandan, to research lymph node targeting vaccine vectors.
et al., 2022, Frequency of transmission, asymptomatic shedding, and airborne spread of Streptococcus pyogenes in schoolchildren exposed to scarlet fever: a prospective, longitudinal, multicohort, molecular epidemiological, contact-tracing study in England, UK., Lancet Microbe, Vol:3, Pages:e366-e375
Siggins MK, Sriskandan S, 2021, Bacterial lymphatic metastasis in infection and immunity, Cells, Vol:11, ISSN:2073-4409
Siggins MK, MacLennan CA, 2021, An adsorption method to prepare specific antibody-depleted normal human serum as a source of complement for human serum bactericidal assays for Salmonella, Vaccine, Vol:39, ISSN:0264-410X, Pages:7503-7509
et al., 2021, Frequency of Transmission, asymptomatic shedding, and airborne spread of Streptococcus pyogenes among school children exposed to scarlet fever: a longitudinal multi-cohort molecular epidemiology contact tracing study, The Lancet Microbe, ISSN:2666-5247
et al., 2021, Commensal bacteria augment Staphylococcus aureus infection by inactivation of phagocyte-derived reactive oxygen species, Plos Pathogens, Vol:17, ISSN:1553-7366