Dr Matthew Siggins is a Research Fellow working with Professor Peter Openshaw's group in the National Heart and Lung Institute. Matthew's research centres on infection, immunity, vaccinology, and immune dysfunction, with a focus on pathogen dissemination within the lymphatic system.
Currently, as part of ISARIC4C and PHOSP-COVID, Dr Siggins is analysing immune responses in large datasets of COVID-19 patients using machine learning to understand the immunology of disease, consequences of infection, as well as potential diagnostics and therapeutics.
Prior to this, he demonstrated how extracellular bacteria, including Streptococcus pyogenes, can move through lymph nodes to drive systemic infection; work that was published in Nature Communications. This lymphatic research is the focus of Dr Siggins's NHLI Research Fellowship.
Dr Siggins is also funded as lead investigator on an Imperial Confidence in Concept (UKRI/Yuhan) grant, working with Professor Shiranee Sriskandan, to research lymph node targeting vaccine vectors.
Siggins MK, Thwaites RS, Openshaw PJM, 2021, Durability of immunity to SARS-CoV-2 and other respiratory viruses, Trends in Microbiology, Vol:29, ISSN:0966-842X, Pages:648-662
et al., 2020, Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection, Nature Communications, Vol:11, ISSN:2041-1723