Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Research Associate



m.siggins Website




345Norfolk PlaceSt Mary's Campus





Fluorescent imaging of flank vasculature that connects lymph nodes

Dr Matthew Siggins is a senior postdoctoral researcher working within Professor Peter Openshaw's group in the National Heart and Lung Institute. Matthew's work centres on infection, immunity, and immune dysfunction, with a focus on the lymphatic system.

Currently, as part of ISARIC4C, he is analysing immune responses in COVID-19 patients to understand the immunology of disease, consequences of infection, and potential therapeutics.

Prior to this, he demonstrated how extracellular bacteria, including Streptococcus pyogenes, can move through lymph nodes to drive systemic infection (Nature Communications: 4697).

Matthew is also funded as lead investigator on an Imperial Confidence in Concept (MRC/BBSRC/Yuhan) grant, working with Professor Shiranee Sriskandan, to research lymph node targeting vaccine vectors.

Selected Publications

Journal Articles

Siggins MK, Thwaites RS, Openshaw PJM, 2021, Durability of immunity to SARS-CoV-2 and other respiratory viruses, Trends in Microbiology, Vol:29, ISSN:0966-842X, Pages:648-662

Siggins MK, Lynskey NN, Lamb L, et al., 2020, Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection, Nature Communications, Vol:11, ISSN:2041-1723

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