Imperial College London
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DrMatthewSiggins

Faculty of Medicine, National Heart & Lung Institute

Research Fellow
 
 
 
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Contact

 

m.siggins Website

 
 
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Location

 

345Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Siggins:2020:10.1038/s41467-020-18454-0,
author = {Siggins, MK and Lynskey, NN and Lamb, L and Johnson, L and Huse, K and Pearson, M and Banerji, S and Turner, CE and Woollard, K and Jackson, DG and Sriskandan, S},
doi = {10.1038/s41467-020-18454-0},
journal = {Nature Communications},
title = {Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection},
url = {http://dx.doi.org/10.1038/s41467-020-18454-0},
volume = {11},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Unassisted metastasis through the lymphatic system is a mechanism of dissemination thus far ascribed only to cancer cells. Here, we report that Streptococcus pyogenes also hijack lymphatic vessels to escape a local infection site, transiting through sequential lymph nodes and efferent lymphatic vessels to enter the bloodstream. Contrasting with previously reported mechanisms of intracellular pathogen carriage by phagocytes, we show S. pyogenes remain extracellular during transit, first in afferent and then efferent lymphatics that carry the bacteria through successive draining lymph nodes. We identify streptococcal virulence mechanisms important for bacterial lymphatic dissemination and show that metastatic streptococci within infected lymph nodes resist and subvert clearance by phagocytes, enabling replication that can seed intense bloodstream infection. The findings establish the lymphatic system as both a survival niche and conduit to the bloodstream for S. pyogenes, explaining the phenomenon of occult bacteraemia. This work provides new perspectives in streptococcal pathogenesis with implications for immunity.
AU  - Siggins,MK
AU  - Lynskey,NN
AU  - Lamb,L
AU  - Johnson,L
AU  - Huse,K
AU  - Pearson,M
AU  - Banerji,S
AU  - Turner,CE
AU  - Woollard,K
AU  - Jackson,DG
AU  - Sriskandan,S
DO  - 10.1038/s41467-020-18454-0
PY  - 2020///
SN  - 2041-1723
TI  - Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-020-18454-0
UR  - http://hdl.handle.net/10044/1/82630
VL  - 11
ER  -
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