Imperial College London
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Professor Michael A. ("Mike") Skinner

Faculty of Medicine, Department of Infectious Disease

Emeritus Professor in Virology
 
 
 
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Contact

 

+44 (0)20 7594 3938m.skinner Website

 
 
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Assistant

 

Mrs Yasmin Mallu +44 (0)20 7594 3972

 
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Location

 

315Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Oliveira:2021:10.3389/fimmu.2020.613079,
author = {Oliveira, M and Rodrigues, DR and Guillory, V and Kut, E and Giotis, ES and Skinner, MA and Guabiraba, R and Bryant, CE and Ferguson, BJ},
doi = {10.3389/fimmu.2020.613079},
journal = {Frontiers in Immunology},
title = {Chicken cGAS senses fowlpox virus infection and regulates macrophage effector functions},
url = {http://dx.doi.org/10.3389/fimmu.2020.613079},
volume = {11},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The anti-viral immune response is dependent on the ability of infected cells to sense foreign nucleic acids. In multiple species, the pattern recognition receptor (PRR) cyclic GMP-AMP synthase (cGAS) senses viral DNA as an essential component of the innate response. cGAS initiates a range of signaling outputs that are dependent on generation of the second messenger cGAMP that binds to the adaptor protein stimulator of interferon genes (STING). Here we show that in chicken macrophages, the cGAS/STING pathway is essential not only for the production of type-I interferons in response to intracellular DNA stimulation, but also for regulation of macrophage effector functions including the expression of MHC-II and co-stimulatory molecules. In the context of fowlpox, an avian DNA virus infection, the cGAS/STING pathway was found to be responsible for type-I interferon production and MHC-II transcription. The sensing of fowlpox virus DNA is therefore essential for mounting an anti-viral response in chicken cells and for regulation of a specific set of macrophage effector functions.
AU  - Oliveira,M
AU  - Rodrigues,DR
AU  - Guillory,V
AU  - Kut,E
AU  - Giotis,ES
AU  - Skinner,MA
AU  - Guabiraba,R
AU  - Bryant,CE
AU  - Ferguson,BJ
DO  - 10.3389/fimmu.2020.613079
PY  - 2021///
SN  - 1664-3224
TI  - Chicken cGAS senses fowlpox virus infection and regulates macrophage effector functions
T2  - Frontiers in Immunology
UR  - http://dx.doi.org/10.3389/fimmu.2020.613079
UR  - http://hdl.handle.net/10044/1/86317
VL  - 11
ER  -
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