Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Armstrong:2018:10.1016/j.addr.2018.06.017,
author = {Armstrong, JP and Stevens, MM},
doi = {10.1016/j.addr.2018.06.017},
journal = {Advanced Drug Delivery Reviews},
pages = {12--16},
title = {Strategic design of extracellular vesicle drug delivery systems},
url = {http://dx.doi.org/10.1016/j.addr.2018.06.017},
volume = {130},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Extracellular vesicles (EVs), sub-micron vectors used in intercellular communication, have demonstrated great promise as natural drug delivery systems. Recent reports have detailed impressive in vivo results from the administration of EVs pre-loaded with therapeutic cargo, including small molecules, nanoparticles, proteins and oligonucleotides. These results have sparked intensive research interest across a huge range of disease models. There are, however, enduring limitations that have restricted widespread clinical and pharmaceutical adoption. In this perspective, we discuss these practical and biological concerns, critically compare the relative merit of EVs and synthetic drug delivery systems, and highlight the need for a more comprehensive understanding of in vivo transport and delivery. Within this framework, we seek to establish key areas in which EVs can gain a competitive advantage in order to provide the tangible added value required for widespread translation.
AU  - Armstrong,JP
AU  - Stevens,MM
DO  - 10.1016/j.addr.2018.06.017
EP  - 16
PY  - 2018///
SN  - 0169-409X
SP  - 12
TI  - Strategic design of extracellular vesicle drug delivery systems
T2  - Advanced Drug Delivery Reviews
UR  - http://dx.doi.org/10.1016/j.addr.2018.06.017
UR  - http://hdl.handle.net/10044/1/61698
VL  - 130
ER  -
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