Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bjornmalm:2019:10.1039/C9SC03325D,
author = {Bjornmalm, A and Wong, LM and Wojciechowski, J and Penders, J and Horgan, C and Booth, MA and Martin, NG and Sattler, S and Stevens, M},
doi = {10.1039/C9SC03325D},
journal = {Chemical Science},
pages = {10179--10194},
title = {In vivo biocompatibility and immunogenicity of metal-phenolic gelation},
url = {http://dx.doi.org/10.1039/C9SC03325D},
volume = {10},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In vivo forming hydrogels are of interest for diverse biomedical applications due totheir ease-of-use and minimal invasiveness and therefore high translational potential. Supramolecular hydrogels that can be assembled usingmetal–phenolic coordination of naturally occurring polyphenols and group IV metal ions (e.g. TiIVor ZrIV) provide a versatile and robust platform for engineering such materials. However, the in situformation and in vivoresponse tothis new class of materials has not yet been reported. Here, we demonstrate that metal–phenolic supramolecular gelation occurs successfully in vivo and we investigate the host response to the material over 14 weeks. TheTiIV–tannic acid materials form stable gels that are well-tolerated following subcutaneous injection. Histology reveals a mild foreign body reaction, and titanium biodistribution studies show low accumulation in distal tissues. Compared to poloxamer-based hydrogels (commonly used for in vivogelation), TiIV–tannic acid materials show a substantially improved in vitrodrug release profile for the corticosteroid dexamethasone (from <1 dayto >10 days). These results provide essential in vivo characterization for this new class of metal–phenolic hydrogels, and highlight their potential suitability for biomedical applications in areas such as drug deliveryand regenerative medicine
AU  - Bjornmalm,A
AU  - Wong,LM
AU  - Wojciechowski,J
AU  - Penders,J
AU  - Horgan,C
AU  - Booth,MA
AU  - Martin,NG
AU  - Sattler,S
AU  - Stevens,M
DO  - 10.1039/C9SC03325D
EP  - 10194
PY  - 2019///
SN  - 2041-6520
SP  - 10179
TI  - In vivo biocompatibility and immunogenicity of metal-phenolic gelation
T2  - Chemical Science
UR  - http://dx.doi.org/10.1039/C9SC03325D
UR  - http://hdl.handle.net/10044/1/73393
VL  - 10
ER  -
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