Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Li:2019:10.1021/jacs.9b09899,
author = {Li, Z and Kosuri, S and Foster, H and Cohen, J and Jumeaux, C and Stevens, MM and Chapman, R and Gormley, AJ},
doi = {10.1021/jacs.9b09899},
journal = {Journal of the American Chemical Society},
pages = {19823--19830},
title = {A dual wavelength polymerization and bioconjugation strategy for high throughput synthesis of multivalent ligands},
url = {http://dx.doi.org/10.1021/jacs.9b09899},
volume = {141},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Structure–function relationships for multivalent polymer scaffolds are highly complex due to the wide diversity of architectures offered by such macromolecules. Evaluation of this landscape has traditionally been accomplished case-by-case due to the experimental difficulty associated with making these complex conjugates. Here, we introduce a simple dual-wavelength, two-step polymerize and click approach for making combinatorial conjugate libraries. It proceeds by incorporation of a polymerization friendly cyclopropenone-masked dibenzocyclooctyne into the side chain of linear polymers or the α-chain end of star polymers. Polymerizations are performed under visible light using an oxygen tolerant porphyrin-catalyzed photoinduced electron/energy transfer-reversible addition–fragmentation chain-transfer (PET-RAFT) process, after which the deprotection and click reaction is triggered by UV light. Using this approach, we are able to precisely control the valency and position of ligands on a polymer scaffold in a manner conducive to high throughput synthesis.
AU  - Li,Z
AU  - Kosuri,S
AU  - Foster,H
AU  - Cohen,J
AU  - Jumeaux,C
AU  - Stevens,MM
AU  - Chapman,R
AU  - Gormley,AJ
DO  - 10.1021/jacs.9b09899
EP  - 19830
PY  - 2019///
SN  - 0002-7863
SP  - 19823
TI  - A dual wavelength polymerization and bioconjugation strategy for high throughput synthesis of multivalent ligands
T2  - Journal of the American Chemical Society
UR  - http://dx.doi.org/10.1021/jacs.9b09899
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000503917800041&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://pubs.acs.org/doi/10.1021/jacs.9b09899
UR  - http://hdl.handle.net/10044/1/77200
VL  - 141
ER  -
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