Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Spicer:2020:10.1021/acscentsci.9b01149,
author = {Spicer, CD and Pujari-Palmer, M and Autefage, H and Insley, G and Procter, P and Engqvist, H and Stevens, M and Stevens, M},
doi = {10.1021/acscentsci.9b01149},
journal = {ACS Central Science},
pages = {226--231},
title = {Synthesis of phospho-amino acid analogues as tissue adhesive cement additives},
url = {http://dx.doi.org/10.1021/acscentsci.9b01149},
volume = {6},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In this paper we report the synthesis of a library of phospho-amino acid analogues, via a novel single-step allyl-phosphoester protection/Pd-mediated deprotection strategy. These phosphoserine and phosphotyrosine analogues were then applied as additives to create adhesive calcium phosphate cements, allowing us to probe the chemical origins of the increased surface binding strength. We demonstrate the importance of multiple calcium binding motifs in mediating adhesion, as well as highlighting the crucial role played by substrate hydrophobicity and orientation in controlling binding strength.
AU  - Spicer,CD
AU  - Pujari-Palmer,M
AU  - Autefage,H
AU  - Insley,G
AU  - Procter,P
AU  - Engqvist,H
AU  - Stevens,M
AU  - Stevens,M
DO  - 10.1021/acscentsci.9b01149
EP  - 231
PY  - 2020///
SN  - 2374-7943
SP  - 226
TI  - Synthesis of phospho-amino acid analogues as tissue adhesive cement additives
T2  - ACS Central Science
UR  - http://dx.doi.org/10.1021/acscentsci.9b01149
UR  - http://hdl.handle.net/10044/1/77367
VL  - 6
ER  -
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