Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Horgan:2021:10.7150/thno.53031,
author = {Horgan, C and Bergholt, M and Nagelkerke, A and Thin, MZ and Pence, IJ and Kauscher, U and Kalber, TL and Stuckey, D and Stevens, M},
doi = {10.7150/thno.53031},
journal = {Theranostics},
pages = {2006--2019},
title = {Integrated photodynamic Raman theranostic system for cancer diagnosis, treatment, and post-treatment molecular monitoring},
url = {http://dx.doi.org/10.7150/thno.53031},
volume = {11},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Theranostics, the combination of diagnosis and therapy, has long held promise as a means to achieving personalised precision cancer treatments. However, despite its potential, theranostics has yet to realise significant clinical translation, largely due the complexity and overriding toxicity concerns of existing theranostic nanoparticle strategies.Methods: Here, we present an alternative nanoparticle-free theranostic approach based on simultaneous Raman spectroscopy and photodynamic therapy (PDT) in an integrated clinical platform for cancer theranostics.Results: We detail the compatibility of Raman spectroscopy and PDT for cancer theranostics, whereby Raman spectroscopic diagnosis can be performed on PDT photosensitiser-positive cells and tissues without inadvertent photosensitiser activation/photobleaching or impaired diagnostic capacity. We further demonstrate that our theranostic platform enables in vivo tumour diagnosis, treatment, and post-treatment molecular monitoring in real-time.Conclusion: This system thus achieves effective theranostic performance, providing a promising new avenue towards the clinical realisation of theranostics.
AU  - Horgan,C
AU  - Bergholt,M
AU  - Nagelkerke,A
AU  - Thin,MZ
AU  - Pence,IJ
AU  - Kauscher,U
AU  - Kalber,TL
AU  - Stuckey,D
AU  - Stevens,M
DO  - 10.7150/thno.53031
EP  - 2019
PY  - 2021///
SN  - 1838-7640
SP  - 2006
TI  - Integrated photodynamic Raman theranostic system for cancer diagnosis, treatment, and post-treatment molecular monitoring
T2  - Theranostics
UR  - http://dx.doi.org/10.7150/thno.53031
UR  - http://hdl.handle.net/10044/1/85937
VL  - 11
ER  -
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