Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Horgan:2021:10.1117/1.JBO.26.3.036002,
author = {Horgan, C and Bergholt, MS and Thin, MZ and Nagelkerke, A and Kennedy, R and Kalber, TL and Stuckey, D and Stevens, M},
doi = {10.1117/1.JBO.26.3.036002},
journal = {Journal of Biomedical Optics},
pages = {1--15},
title = {Image-guided Raman spectroscopy probe-tracking for tumor margin delineation},
url = {http://dx.doi.org/10.1117/1.JBO.26.3.036002},
volume = {26},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Significance: Tumor detection and margin delineation are essential for successful tumor resection. However, postsurgical positive margin rates remain high for many cancers. Raman spectroscopy has shown promise as a highly accurate clinical spectroscopic diagnostic modality, but its margin delineation capabilities are severely limited by the need for pointwise application.Aim: We aim to extend Raman spectroscopic diagnostics and develop a multimodal computer vision-based diagnostic system capable of both the detection and identification of suspicious lesions and the precise delineation of disease margins.Approach: We first apply visual tracking of a Raman spectroscopic probe to achieve real-time tumor margin delineation. We then combine this system with protoporphyrin IX fluorescence imaging to achieve fluorescence-guided Raman spectroscopic margin delineation.Results: Our system enables real-time Raman spectroscopic tumor margin delineation for both ex vivo human tumor biopsies and an in vivo tumor xenograft mouse model. We then further demonstrate that the addition of protoporphyrin IX fluorescence imaging enables fluorescence-guided Raman spectroscopic margin delineation in a tissue phantom model.Conclusions: Our image-guided Raman spectroscopic probe-tracking system enables tumor margin delineation and is compatible with both white light and fluorescence image guidance, demonstrating the potential for our system to be developed toward clinical tumor resection surgeries.
AU  - Horgan,C
AU  - Bergholt,MS
AU  - Thin,MZ
AU  - Nagelkerke,A
AU  - Kennedy,R
AU  - Kalber,TL
AU  - Stuckey,D
AU  - Stevens,M
DO  - 10.1117/1.JBO.26.3.036002
EP  - 15
PY  - 2021///
SN  - 1083-3668
SP  - 1
TI  - Image-guided Raman spectroscopy probe-tracking for tumor margin delineation
T2  - Journal of Biomedical Optics
UR  - http://dx.doi.org/10.1117/1.JBO.26.3.036002
UR  - https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-26/issue-03/036002/Image-guided-Raman-spectroscopy-probe-tracking-for-tumor-margin-delineation/10.1117/1.JBO.26.3.036002.full?SSO=1
UR  - http://hdl.handle.net/10044/1/88113
VL  - 26
ER  -
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