Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nele:2021:10.1021/acs.langmuir.1c02076,
author = {Nele, V and Holme, M and Rashid, MH and Barriga, HMG and Le, TC and Thomas, MR and Doutch, JJ and Yarovsky, I and Stevens, MM},
doi = {10.1021/acs.langmuir.1c02076},
journal = {Langmuir: the ACS journal of surfaces and colloids},
pages = {11909--11921},
title = {Design of lipid-based nanocarriers via cation modulation of ethanol-interdigitated lipid membranes},
url = {http://dx.doi.org/10.1021/acs.langmuir.1c02076},
volume = {37},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Short-chain alcohols (i.e., ethanol) can induce membrane interdigitation in saturated-chain phosphatidylcholines (PCs). In this process, alcohol molecules intercalate between phosphate heads, increasing lateral separation and favoring hydrophobic interactions between opposing acyl chains, which interpenetrate forming an interdigitated phase. Unraveling mechanisms underlying the interactions between ethanol and model lipid membranes has implications for cell biology, biochemistry, and for the formulation of lipid-based nanocarriers. However, investigations of ethanol–lipid membrane systems have been carried out in deionized water, which limits their applicability. Here, using a combination of small- and wide-angle X-ray scattering, small-angle neutron scattering, and all-atom molecular dynamics simulations, we analyzed the effect of varying CaCl2 and NaCl concentrations on ethanol-induced interdigitation. We observed that while ethanol addition leads to the interdigitation of bulk phase 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) bilayers in the presence of CaCl2 and NaCl regardless of the salt concentration, the ethanol-induced interdigitation of vesicular DPPC depends on the choice of cation and its concentration. These findings unravel a key role for cations in the ethanol-induced interdigitation of lipid membranes in either bulk phase or vesicular form.
AU  - Nele,V
AU  - Holme,M
AU  - Rashid,MH
AU  - Barriga,HMG
AU  - Le,TC
AU  - Thomas,MR
AU  - Doutch,JJ
AU  - Yarovsky,I
AU  - Stevens,MM
DO  - 10.1021/acs.langmuir.1c02076
EP  - 11921
PY  - 2021///
SN  - 0743-7463
SP  - 11909
TI  - Design of lipid-based nanocarriers via cation modulation of ethanol-interdigitated lipid membranes
T2  - Langmuir: the ACS journal of surfaces and colloids
UR  - http://dx.doi.org/10.1021/acs.langmuir.1c02076
UR  - http://hdl.handle.net/10044/1/92201
VL  - 37
ER  -
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