Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ren:2022:10.1017/s1431927621012976,
author = {Ren, Y and Autefage, H and Jones, JR and Stevens, MM and Bagot, PAJ and Moody, MP},
doi = {10.1017/s1431927621012976},
journal = {Microscopy and Microanalysis},
pages = {1310--1320},
title = {Developing atom probe tomography to characterize Sr-loaded bioactive glass for bone scaffolding},
url = {http://dx.doi.org/10.1017/s1431927621012976},
volume = {28},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In this study, atom probe tomography (APT) was used to investigate strontium-containing bioactive glass particles (BG-Sr10) and strontium-releasing bioactive glass-based scaffolds (pSrBG), both of which are attractive biomaterials with applications in critical bone damage repair. We outline the challenges and corresponding countermeasures of this nonconductive biomaterial for APT sample preparation and experiments, such as avoiding direct contact between focussed ion beam micromanipulators and the extracted cantilever to reduce damage during liftout. Using a low imaging voltage (≤3 kV) and current (≤500 pA) in the scanning electron microscope and a low acceleration voltage (≤2 kV) and current (≤200 pA) in the focussed ion beam prevents tip bending in the final stages of annular milling. To optimize the atom probe experiment, we considered five factors: total detected hits, multiple hits, the background level, the charge-state ratio, and the accuracy of the measured compositions, to explore the optimal laser pulse for BG-Sr10 bioactive glass. We show that a stage temperature of 30 K, 200–250 pJ laser pulse energy, 0.3% detection rate, and 200 kHz pulse rate are optimized experimental parameters for bioactive glass. The use of improved experimental preparation methods and optimized parameters resulted in a 90% successful yield of pSrBG samples by APT.
AU  - Ren,Y
AU  - Autefage,H
AU  - Jones,JR
AU  - Stevens,MM
AU  - Bagot,PAJ
AU  - Moody,MP
DO  - 10.1017/s1431927621012976
EP  - 1320
PY  - 2022///
SN  - 1431-9276
SP  - 1310
TI  - Developing atom probe tomography to characterize Sr-loaded bioactive glass for bone scaffolding
T2  - Microscopy and Microanalysis
UR  - http://dx.doi.org/10.1017/s1431927621012976
UR  - https://www.cambridge.org/core/journals/microscopy-and-microanalysis/article/developing-atom-probe-tomography-to-characterize-srloaded-bioactive-glass-for-bone-scaffolding/2D03F9CDAD6EE09F94FDCC822AFAA9A4
VL  - 28
ER  -
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