Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Artzy-Schnirman:2022:10.1021/acs.nanolett.2c00819,
author = {Artzy-Schnirman, A and Abu-Shah, E and Chandrawati, R and Altman, E and Yusuf, N and Wang, S-T and Ramos, J and Hansel, C and Haus-Cohen, M and Dahan, R and Arif, S and Dustin, ML and Reiter, Y and Stevens, MM},
doi = {10.1021/acs.nanolett.2c00819},
journal = {Nano Letters: a journal dedicated to nanoscience and nanotechnology},
pages = {4376--4382},
title = {Artificial antigen presenting cells for detection and desensitisation of auto-reactive T cells associated with Type 1 diabetes},
url = {http://dx.doi.org/10.1021/acs.nanolett.2c00819},
volume = {22},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Autoimmune diseases and in particular type 1 diabetes rely heavily on treatments that target the symptoms rather than prevent the underlying disease. One of the barriers to better therapeutic strategies is the inability to detect and efficiently target rare autoreactive T-cell populations that are major drivers of these conditions. Here, we develop a unique artificial antigen-presenting cell (aAPC) system from biocompatible polymer particles that allows specific encapsulation of bioactive ingredients. Using our aAPC, we demonstrate that we are able to detect rare autoreactive CD4 populations in human patients, and using mouse models, we demonstrate that our particles are able to induce desensitization in the autoreactive population. This system provides a promising tool that can be used in the prevention of autoimmunity before disease onset.
AU  - Artzy-Schnirman,A
AU  - Abu-Shah,E
AU  - Chandrawati,R
AU  - Altman,E
AU  - Yusuf,N
AU  - Wang,S-T
AU  - Ramos,J
AU  - Hansel,C
AU  - Haus-Cohen,M
AU  - Dahan,R
AU  - Arif,S
AU  - Dustin,ML
AU  - Reiter,Y
AU  - Stevens,MM
DO  - 10.1021/acs.nanolett.2c00819
EP  - 4382
PY  - 2022///
SN  - 1530-6984
SP  - 4376
TI  - Artificial antigen presenting cells for detection and desensitisation of auto-reactive T cells associated with Type 1 diabetes
T2  - Nano Letters: a journal dedicated to nanoscience and nanotechnology
UR  - http://dx.doi.org/10.1021/acs.nanolett.2c00819
UR  - http://hdl.handle.net/10044/1/96838
VL  - 22
ER  -
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