Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sun:2022:10.1002/adma.202207791,
author = {Sun, R and Song, X and Zhou, K and Zuo, Y and Wang, R and Rifaie, Graham O and Leng, Y and Peeler, D and Xie, R and Geng, H and Brachi, G and Ma, Y and Liu, Y and Barron, L and Stevens, M},
doi = {10.1002/adma.202207791},
journal = {Advanced Materials},
pages = {1--14},
title = {Assembly of fillable microrobotic systems by microfluidic loading with dip sealing},
url = {http://dx.doi.org/10.1002/adma.202207791},
volume = {35},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Microrobots can provide spatiotemporally well-controlled cargo delivery that can improve therapeutic efficiency compared to conventional drug delivery strategies. Robust microfabrication methods to expand the variety of materials or cargoes that can be incorporated into microrobots can greatly broaden the scope of their functions. However, current surface coating or direct blending techniques used for cargo loading result in inefficient loading and poor cargo protection during transportation, which leads to cargo waste, degradation and non-specific release. Herein, a versatile platform to fabricate fillable microrobots using microfluidic loading and dip sealing (MLDS) is presented. MLDS enables the encapsulation of different types of cargoes within hollow microrobots and protection of cargo integrity. The technique is supported by high-resolution 3D printing with an integrated microfluidic loading system, which realizes a highly precise loading process and improves cargo loading capacity. A corresponding dip sealing strategy is developed to encase and protect the loaded cargo whilst maintaining the geometric and structural integrity of the loaded microrobots. This dip sealing technique is suitable for different materials, including thermal and light-responsive materials. The MLDS platform provides new opportunities for microrobotic systems in targeted drug delivery, environmental sensing, and chemically powered micromotor applications.
AU  - Sun,R
AU  - Song,X
AU  - Zhou,K
AU  - Zuo,Y
AU  - Wang,R
AU  - Rifaie,Graham O
AU  - Leng,Y
AU  - Peeler,D
AU  - Xie,R
AU  - Geng,H
AU  - Brachi,G
AU  - Ma,Y
AU  - Liu,Y
AU  - Barron,L
AU  - Stevens,M
DO  - 10.1002/adma.202207791
EP  - 14
PY  - 2022///
SN  - 0935-9648
SP  - 1
TI  - Assembly of fillable microrobotic systems by microfluidic loading with dip sealing
T2  - Advanced Materials
UR  - http://dx.doi.org/10.1002/adma.202207791
UR  - https://onlinelibrary.wiley.com/doi/10.1002/adma.202207791
UR  - http://hdl.handle.net/10044/1/102136
VL  - 35
ER  -
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