Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Callens:2023:10.1038/s41467-023-36436-w,
author = {Callens, SJP and Fan, D and van, Hengel IAJ and Minneboo, M and Díaz-Payno, PJ and Stevens, MM and Fratila-Apachitei, LE and Zadpoor, AA},
doi = {10.1038/s41467-023-36436-w},
journal = {Nature Communications},
pages = {1--19},
title = {Emergent collective organization of bone cells in complex curvature fields},
url = {http://dx.doi.org/10.1038/s41467-023-36436-w},
volume = {14},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Individual cells and multicellular systems respond to cell-scale curvatures in their environments, guiding migration, orientation, and tissue formation. However, it remains largely unclear how cells collectively explore and pattern complex landscapes with curvature gradients across the Euclidean and non-Euclidean spectra. Here, we show that mathematically designed substrates with controlled curvature variations induce multicellular spatiotemporal organization of preosteoblasts. We quantify curvature-induced patterning and find that cells generally prefer regions with at least one negative principal curvature. However, we also show that the developing tissue can eventually cover unfavorably curved territories, can bridge large portions of the substrates, and is often characterized by collectively aligned stress fibers. We demonstrate that this is partly regulated by cellular contractility and extracellular matrix development, underscoring the mechanical nature of curvature guidance. Our findings offer a geometric perspective on cell-environment interactions that could be harnessed in tissue engineering and regenerative medicine applications.
AU  - Callens,SJP
AU  - Fan,D
AU  - van,Hengel IAJ
AU  - Minneboo,M
AU  - Díaz-Payno,PJ
AU  - Stevens,MM
AU  - Fratila-Apachitei,LE
AU  - Zadpoor,AA
DO  - 10.1038/s41467-023-36436-w
EP  - 19
PY  - 2023///
SN  - 2041-1723
SP  - 1
TI  - Emergent collective organization of bone cells in complex curvature fields
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-023-36436-w
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36869036
UR  - https://www.nature.com/articles/s41467-023-36436-w
UR  - http://hdl.handle.net/10044/1/102920
VL  - 14
ER  -
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