Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fiocco:2016:10.1016/j.actbio.2016.12.043,
author = {Fiocco, L and Li, S and Stevens, MM and Bernardo, E and Jones, JR},
doi = {10.1016/j.actbio.2016.12.043},
journal = {Acta Biomaterialia},
pages = {56--67},
title = {Biocompatibility and bioactivity of porous polymer-derived Ca-Mg silicate ceramics.},
url = {http://dx.doi.org/10.1016/j.actbio.2016.12.043},
volume = {50},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Magnesium is a trace element in the human body, known to have important effects on cell differentiation and the mineralisation of calcified tissues. This study aimed to synthesise highly porous Ca-Mg silicate foamed scaffolds from preceramic polymers, with analysis of their biological response. Akermanite (Ak) and wollastonite-diopside (WD) ceramic foams were obtained from the pyrolysis of a liquid silicone mixed with reactive fillers. The porous structure was obtained by controlled water release from selected fillers (magnesium hydroxide and borax) at 350°C. The homogeneous distribution of open pores, with interconnects of modal diameters of 160-180μm was obtained and maintained after firing at 1100°C. Foams, with porosity exceeding 80%, exhibited compressive strength values of 1-2MPa. In vitro studies were conducted by immersion in SBF for 21days, showing suitable dissolution rates, pH and ionic concentrations. Cytotoxicity analysis performed in accordance with ISO10993-5 and ISO10993-12 standards confirmed excellent biocompatibility of both Ak and WD foams. In addition, MC3T3-E1 cells cultured on the Mg-containing scaffolds demonstrated enhanced osteogenic differentiation and the expression of osteogenic markers including Collagen Type I, Osteopontin and Osteocalcin, in comparison to Mg-free counterparts. The results suggest that the addition of magnesium can further enhance the bioactivity and the potential for bone regeneration applications of Ca-silicate materials. STATEMENTS OF SIGNIFICANCE: Here, we show that the incorporation of Mg in Ca-silicates plays a significant role in the enhancement of the osteogenic differentiation and matrix formation of MC3T3-E1 cells, cultured on polymer-derived highly porous scaffolds. Reduced degradation rates and improved mechanical properties are also observed, compared to Mg-free counterparts, suggesting the great potential of Ca-Mg silicates as bone tissue engineering materials. Excellent biocompatibility of the
AU  - Fiocco,L
AU  - Li,S
AU  - Stevens,MM
AU  - Bernardo,E
AU  - Jones,JR
DO  - 10.1016/j.actbio.2016.12.043
EP  - 67
PY  - 2016///
SN  - 1878-7568
SP  - 56
TI  - Biocompatibility and bioactivity of porous polymer-derived Ca-Mg silicate ceramics.
T2  - Acta Biomaterialia
UR  - http://dx.doi.org/10.1016/j.actbio.2016.12.043
UR  - http://www.ncbi.nlm.nih.gov/pubmed/28017870
UR  - http://hdl.handle.net/10044/1/43928
VL  - 50
ER  -
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