Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Armstrong:2017:10.1021/acsnano.6b07607,
author = {Armstrong, JPK and Holme, MN and Stevens, MM},
doi = {10.1021/acsnano.6b07607},
journal = {ACS Nano},
pages = {69--83},
title = {Re-Engineering Extracellular Vesicles as Smart Nanoscale Therapeutics},
url = {http://dx.doi.org/10.1021/acsnano.6b07607},
volume = {11},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In the past decade, extracellular vesicles(EVs) have emerged as a key cell-free strategy for thetreatment of a range of pathologies, including cancer,myocardial infarction, and inflammatory diseases. Indeed,the field is rapidly transitioning from promising in vitroreports toward in vivo animal models and early clinicalstudies. These investigations exploit the high physicochemicalstability and biocompatibility of EVs as well as theirinnate capacity to communicate with cells via signaltransduction and membrane fusion. This review focuseson methods in which EVs can be chemically or biologicallymodified to broaden, alter, or enhance their therapeuticcapability. We examine two broad strategies, which havebeen used to introduce a wide range of nanoparticles, reporter systems, targeting peptides, pharmaceutics, and functionalRNA molecules. First, we explore how EVs can be modified by manipulating their parent cells, either through genetic ormetabolic engineering or by introducing exogenous material that is subsequently incorporated into secreted EVs. Second,we consider how EVs can be directly functionalized using strategies such as hydrophobic insertion, covalent surfacechemistry, and membrane permeabilization. We discuss the historical context of each specific technology, presentprominent examples, and evaluate the complexities, potential pitfalls, and opportunities presented by different reengineeringstrategies.
AU  - Armstrong,JPK
AU  - Holme,MN
AU  - Stevens,MM
DO  - 10.1021/acsnano.6b07607
EP  - 83
PY  - 2017///
SN  - 1936-0851
SP  - 69
TI  - Re-Engineering Extracellular Vesicles as Smart Nanoscale Therapeutics
T2  - ACS Nano
UR  - http://dx.doi.org/10.1021/acsnano.6b07607
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000392886500008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/48498
VL  - 11
ER  -
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