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@article{Li:2017:10.1177/0885328217706640,
author = {Li, S and Macon, ALB and Jacquemin, M and Stevens, MM and Jones, JR},
doi = {10.1177/0885328217706640},
journal = {Journal of Biomaterials Applications},
pages = {104--113},
title = {Sol-gel derived lithium-releasing glass for cartilage regeneration},
url = {http://dx.doi.org/10.1177/0885328217706640},
volume = {32},
year = {2017}
}

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TY  - JOUR
AB  - Wnt-signalling cascadeis one of the crucial pathways involved in the development and homeostasis of cartilage. Influencing this pathway can potentially contribute to improved cartilage repair or regeneration. One key molecular regulator of the Wnt pathway is the glycogen synthase kinase-3 (GSK-3) enzyme, the inhibition of which allows initiation of the signalling pathway. This study aims to utilise a binary SiO2-Li2O sol-gel derived glass for controlled delivery of lithium, a known GSK-3 antagonist. The effect of the dissolution products of the glass on chondrogenic differentiation inanin vitro3-D pellet culture modelis reported. Dissolution productsthat contained5 mM lithium and 3.5 mM silicon, were capable of inducing chondrogenic differentiation and hyaline cartilaginous matrix formation without the presence of growth factors such as TGF-β3. The results suggest that sol-gel derived glass has the potential to be used as a delivery vehicle for therapeutic lithium ions in cartilage regeneration applications.
AU  - Li,S
AU  - Macon,ALB
AU  - Jacquemin,M
AU  - Stevens,MM
AU  - Jones,JR
DO  - 10.1177/0885328217706640
EP  - 113
PY  - 2017///
SN  - 0885-3282
SP  - 104
TI  - Sol-gel derived lithium-releasing glass for cartilage regeneration
T2  - Journal of Biomaterials Applications
UR  - http://dx.doi.org/10.1177/0885328217706640
UR  - http://hdl.handle.net/10044/1/46249
VL  - 32
ER  -

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