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@article{Tennant:2001,
author = {Tennant, M and McRee, DE},
journal = {Curr Opin Drug Discov Devel},
pages = {671--677},
title = {The first structure of a microsomal P450--implications for drug discovery.},
url = {https://www.ncbi.nlm.nih.gov/pubmed/12825462},
volume = {4},
year = {2001}
}

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TY  - JOUR
AB  - Although numerous microbial, soluble P450 structures have been known for some time, it is only recently that the first crystal structure of a microsomal, membrane-associated P450 has been determined. The structure gives an increased understanding of the membrane, substrate and reductase binding surfaces, and has enabled the modeling of other P450s with greater accuracy. Other milestones include the first determination of a true P450 drug target, CYP51, the determination of a thermophilic P450 and the structures of cryogenically trapped intermediates of the P450 reaction cycle.
AU  - Tennant,M
AU  - McRee,DE
EP  - 677
PY  - 2001///
SN  - 1367-6733
SP  - 671
TI  - The first structure of a microsomal P450--implications for drug discovery.
T2  - Curr Opin Drug Discov Devel
UR  - https://www.ncbi.nlm.nih.gov/pubmed/12825462
VL  - 4
ER  -

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