Imperial College London
Alternate

ProfessorMarkThursz

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Hepatology. Head of Department
 
 
 
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Contact

 

+44 (0)20 3312 1903m.thursz

 
 
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Assistant

 

Ms Dawn Campbell +44 (0)20 3312 6454

 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Middleton:2021:10.1038/s41598-021-81930-0,
author = {Middleton, P and Perez-Guzman, PN and Cheng, A and Kumar, N and Kont, M and Daunt, A and Mukherjee, S and Cooke, G and Hallett, TB and Hauck, K and White, PJ and Thursz, MR and Nayagam, S},
doi = {10.1038/s41598-021-81930-0},
journal = {Scientific Reports},
pages = {1--7},
title = {Characteristics and outcomes of clinically diagnosed RT-PCR swab negative COVID-19: a retrospective cohort study},
url = {http://dx.doi.org/10.1038/s41598-021-81930-0},
volume = {11},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Patients with strong clinical features of COVID-19 with negative real time polymerase chain reaction (RT-PCR) SARS-CoV-2 testing are not currently included in official statistics. The scale, characteristics and clinical relevance of this group are not well described. We performed a retrospective cohort study in two large London hospitals to characterize the demographic, clinical, and hospitalization outcome characteristics of swab-negative clinical COVID-19 patients. We found 1 in 5 patients with a negative swab and clinical suspicion of COVID-19 received a clinical diagnosis of COVID-19 within clinical documentation, discharge summary or death certificate. We compared this group to a similar swab positive cohort and found similar demographic composition, symptomology and laboratory findings. Swab-negative clinical COVID-19 patients had better outcomes, with shorter length of hospital stay, reduced need for >60% supplementary oxygen and reduced mortality. Patients with strong clinical features of COVID-19 that are swab-negative are a common clinical challenge. Health systems must recognize and plan for the management of swab-negative patients in their COVID-19 clinical management, infection control policies and epidemiological assessments.
AU  - Middleton,P
AU  - Perez-Guzman,PN
AU  - Cheng,A
AU  - Kumar,N
AU  - Kont,M
AU  - Daunt,A
AU  - Mukherjee,S
AU  - Cooke,G
AU  - Hallett,TB
AU  - Hauck,K
AU  - White,PJ
AU  - Thursz,MR
AU  - Nayagam,S
DO  - 10.1038/s41598-021-81930-0
EP  - 7
PY  - 2021///
SN  - 2045-2322
SP  - 1
TI  - Characteristics and outcomes of clinically diagnosed RT-PCR swab negative COVID-19: a retrospective cohort study
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-021-81930-0
UR  - https://www.nature.com/articles/s41598-021-81930-0
UR  - http://hdl.handle.net/10044/1/85491
VL  - 11
ER  -
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