Imperial College London
Alternate

ProfessorMarkThursz

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Hepatology. Head of Department
 
 
 
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Contact

 

+44 (0)20 3312 1903m.thursz

 
 
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Assistant

 

Ms Dawn Campbell +44 (0)20 3312 6454

 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jambulingam:2023:10.3390/ijms24043563,
author = {Jambulingam, N and Forlano, R and Preston, B and Mullish, BH and Portone, G and Baheer, Y and Yee, M and Goldin, RD and Thursz, MR and Manousou, P},
doi = {10.3390/ijms24043563},
journal = {International Journal of Molecular Sciences},
pages = {3563--3563},
title = {Metabolic Profile Reflects Stages of Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease},
url = {http://dx.doi.org/10.3390/ijms24043563},
volume = {24},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:p>Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease worldwide, with fibrosis stage being the main predictor for clinical outcomes. Here, we present the metabolic profile of NAFLD patients with regards to fibrosis progression. We included all consecutive new referrals for NAFLD services between 2011 and 2019. Demographic, anthropometric and clinical features and noninvasive markers of fibrosis were recorded at baseline and at follow-up. Significant and advanced fibrosis were defined using liver stiffness measurement (LSM) as LSM ≥ 8.1 kPa and LSM ≥ 12.1 kPa, respectively. Cirrhosis was diagnosed either histologically or clinically. Fast progressors of fibrosis were defined as those with delta stiffness ≥ 1.03 kPa/year (25% upper quartile of delta stiffness distribution). Targeted and untargeted metabolic profiles were analysed on fasting serum samples using Proton nuclear magnetic resonance (1H NMR). A total of 189 patients were included in the study; 111 (58.7%) underwent liver biopsy. Overall, 11.1% patients were diagnosed with cirrhosis, while 23.8% were classified as fast progressors. A combination of metabolites and lipoproteins could identify the fast fibrosis progressors (AUROC 0.788, 95% CI: 0.703–0.874, p < 0.001) and performed better than noninvasive markers. Specific metabolic profiles predict fibrosis progression in patients with nonalcoholic fatty liver disease. Algorithms combining metabolites and lipids could be integrated in the risk-stratification of these patients.</jats:p>
AU  - Jambulingam,N
AU  - Forlano,R
AU  - Preston,B
AU  - Mullish,BH
AU  - Portone,G
AU  - Baheer,Y
AU  - Yee,M
AU  - Goldin,RD
AU  - Thursz,MR
AU  - Manousou,P
DO  - 10.3390/ijms24043563
EP  - 3563
PY  - 2023///
SP  - 3563
TI  - Metabolic Profile Reflects Stages of Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease
T2  - International Journal of Molecular Sciences
UR  - http://dx.doi.org/10.3390/ijms24043563
UR  - http://hdl.handle.net/10044/1/102964
VL  - 24
ER  -
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