Publications
154 results found
Ashworth DC, Fuller GW, Toledano MB, et al., 2013, Comparative Assessment of Particulate Air Pollution, Exposure from Municipal Solid Waste Incinerator Emissions, Vol: 2013, ISSN: 1660-4601
Background. Research to date on health effects associated with incineration has found limited evidence of health risks, but many previous studies have been constrained by poor exposure assessment. This paper provides a comparative assessment of atmospheric dispersion modelling and distance from source (a commonly used proxy for exposure) as exposure assessment methods for pollutants released from incinerators. Methods. Distance from source and the atmospheric dispersion model ADMS-Urban were used to characterise ambient exposures to particulates from two municipal solid waste incinerators (MSWIs) in the UK. Additionally an exploration of the sensitivity of the dispersion model simulations to input parameters was performed. Results. The model output indicated extremely low ground level concentrations of PM10, with maximum concentrations of <0.01 μg/m3. Proximity and modelled PM10 concentrations for both MSWIs at postcode level were highly correlated when using continuous measures (Spearman correlation coefficients ~ 0.7) but showed poor agreement for categorical measures (deciles or quintiles, Cohen’s kappa coefficients ≤ 0.5). Conclusion. To provide the most appropriate estimate of ambient exposure from MSWIs, it is essential that incinerator characteristics, magnitude of emissions, and surrounding meteorological and topographical conditions are considered. Reducing exposure misclassification is particularly important in environmental epidemiology to aid detection of low-level risks.
Ladep NG, Khan SA, Thillainayagam AV, et al., 2012, RECENT TRENDS IN PRIMARY LIVER CANCER IN ENGLAND AND WALES, GUT, Vol: 61, Pages: A406-A407, ISSN: 0017-5749
Briggs D, Beale L, Bennett J, et al., 2012, A geographical model of radio-frequency power density around mobile phone masts, SCIENCE OF THE TOTAL ENVIRONMENT, Vol: 426, Pages: 233-243, ISSN: 0048-9697
- Author Web Link
- Cite
- Citations: 13
Ward H, Toledano MB, Shaddick G, et al., 2012, Oxford Handbook of Epidemiology for Clinicians, Publisher: OUP Oxford, ISBN: 9780198529880
The Oxford Handbook of Epidemiology for Clinicians is the essential reference for all clinicians and junior doctors who need to apply clinical evidence in everyday practice.
Ladep NG, Khan SA, Thillainayagam AV, et al., 2012, MORTALITY RATES OF PRIMARY LIVER CANCER ARE CONTINUING TO INCREASE GLOBALLY, 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S287-S287, ISSN: 0168-8278
Robinson O, Toledano MB, Goldin R, et al., 2012, HIRMI VALLEY LIVER DISEASE: A TALE OF TWO TOXINS, 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S33-S34, ISSN: 0168-8278
Khan SA, Emadossadaty S, Ladep NG, et al., 2012, Rising trends in cholangiocarcinoma: Is the ICD classification system misleading us?, JOURNAL OF HEPATOLOGY, Vol: 56, Pages: 848-854, ISSN: 0168-8278
- Author Web Link
- Cite
- Citations: 213
Khan SA, Toledano MB, Ahmed M, et al., 2012, Liver Cancer: The view from the United Kingdom, Clinical Dilemmas in Primary Liver Cancer, Editors: Williams, Taylor-Robinson, Publisher: Wiley, ISBN: 9780470657973
Incidence and mortality rates for both chronic liver disease (CLD) and liver cancer are increasing steadily in the United Kingdom. This is related to an increase in known risk factors. Alcohol consumption and non-alcoholic fatty liverdisease (NAFLD) have increased over recent decades. Chronic viral hepatitis has also increased because of increased immigration from hepatitis C virus(HBV)-endemic regions of the world and because of patients infected with hepatitis C virus (HCV) 20–30 years ago now presenting with clinical disease. There is currently a need for organised, formal hepatocellular carcinoma (HCC) surveillance, while increased incidence presents challenges for allocation of resources for treatment of HCC. Political help will be required, as the increasing health burden of liver disease raises public health issues in relation to health funding and addressing the underlying causes.
Khan SA, Toledano MB, Zabron A, et al., 2012, The view from the United Kingdom, CLINICAL DILEMMAS IN PRIMARY LIVER CANCER, Pages: 24-28
Iszatt N, Nieuwenhuijsen MJ, Nelson P, et al., 2011, Water Consumption and Use, Trihalomethane Exposure, and the Risk of Hypospadias, PEDIATRICS, Vol: 127, Pages: E389-E397, ISSN: 0031-4005
- Author Web Link
- Cite
- Citations: 24
Schuz J, Elliott P, Auvinen A, et al., 2011, An international prospective cohort study of mobile phone users and health (Cosmos): Design considerations and enrolment, CANCER EPIDEMIOLOGY, Vol: 35, Pages: 37-43, ISSN: 1877-7821
- Author Web Link
- Cite
- Citations: 53
Elliott P, Toledano MB, Bennett JE, et al., 2011, Case-control Study of Mobile Phone Base Stations and Early Childhood Cancers, Joint Conference of International-Society-of-Exposure-Science/International-Society-for-Environmental-Epidemiology, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S52-S53, ISSN: 1044-3983
- Author Web Link
- Cite
- Citations: 1
Iszatt N, Nieuwenhuijsen MJ, Bennett JE, et al., 2011, Trihalomethane Levels in Relation to Rates of Stillbirth and Low Birth Weight: An Intervention Study, Joint Conference of International-Society-of-Exposure-Science/International-Society-for-Environmental-Epidemiology, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S68-S69, ISSN: 1044-3983
Kogevinas M, Patelarou E, Villanueva CM, et al., 2011, Disinfection Byproducts, Polymorphisms, and Susceptibility to Adverse Pregnancy Outcomes, Joint Conference of International-Society-of-Exposure-Science/International-Society-for-Environmental-Epidemiology, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S67-S68, ISSN: 1044-3983
Smith RB, Nieuwenhuijsen MJ, Bennett JE, et al., 2011, Exposure to Disinfection By-products During Pregnancy, Joint Conference of International-Society-of-Exposure-Science/International-Society-for-Environmental-Epidemiology, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S122-S122, ISSN: 1044-3983
Li G, Richardson S, Fortunato L, et al., 2011, Data mining cancer registries: retrospective surveillance of small area time trends in cancer incidence using BaySTDetect, Data Mining Workshops (ICDMW), 2011 IEEE 11th International Conference
Space-time modelling of small area data is often used in epidemiology for mapping temporal trends in chronic disease rates. For rare diseases such as cancers, data are sparse, and a Bayesian hierarchical modelling approach is typically adopted in order to smooth the raw disease rates. Although there may be a general temporal trend which affect all areas similarly, abrupt changes may also occur in particular areas due to, for example, emergence of localized risk factor(s) or impact of a new health or screening policy. Detection of areas with “unusual” temporal patterns is therefore important to flag-up areas warranting further investigations.In this paper, we present a novel area of application of a recently proposed detection method, BaySTDetect, for short time series of small area data. Placed within the Bayesian model choice framework, BaySTDetect detects unusual time trends based on comparison of two competing space-time models. The first model is a straightforward multiplicative decomposition of the area effect and the temporal effect, assuming one single temporal pattern across the whole study region. The second model estimates a local time trend, independently for each area. An area-specific model indicator is introduced to select which model offers a better description of the local data. Classification of an area local time trend as “unusual” or not is based on the posterior mean of this model indicator, which represents the probability that the common trend model is appropriate for that area. An important feature of the method is that the classification rule can be fine-tuned to control the false detection rate (FDR). Based on previous simulation results, we present some further insights of the model specification in relation to the detection performance in practice. BaySTDetect is then applied to data on several different cancers collected by the Thames Cancer Registry in South East England to illustrate its potential in retrospectiv
Nieuwenhuijsen MJ, Martinez D, Grellier J, et al., 2010, Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses, CIENCIA & SAUDE COLETIVA, Vol: 15, Pages: 3109-3123, ISSN: 1413-8123
- Author Web Link
- Open Access Link
- Cite
- Citations: 1
Nieuwenhuijsen MJ, Martinez D, Grellier J, et al., 2010, Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses., Cien Saude Colet, Vol: 15 Suppl 2, Pages: 3109-3123, ISSN: 1678-4561
This study aims to review epidemiologic evidence of the association between exposure to chlorination disinfection by-products (DBPs) and congenital anomalies. All epidemiologic studies that evaluated a relationship between an index of DBP exposure and risk of congenital anomalies were analyzed. For all congenital anomalies combined, the meta-analysis gave a statistically significant excess risk for high versus low exposure to water chlorination or TTHM (17%; 95% CI, 3-34) based on a small number of studies. The meta-analysis also suggested a statistically significant excess risk for ventricular septal defects (58%; 95% CI, 21-107), but based on only three studies, and there was little evidence of an exposure-response relationship. It was observed no statistically significant relationships in the other meta-analyses and little evidence for publication bias, except for urinary tract defects and cleft lip and palate. Although some individual studies have suggested an association between chlorination disinfection by-products and congenital anomalies, meta-analyses of all currently available studies demonstrate little evidence of such association.
Elliott P, Toledano MB, Bennett J, et al., 2010, Mobile phone base stations and early childhood cancers: case-control study, BMJ-BRITISH MEDICAL JOURNAL, Vol: 340, ISSN: 1756-1833
- Author Web Link
- Cite
- Citations: 30
Khan SA, Emadossadaty S, Taylor-Robinson SD, et al., 2010, MISCLASSIFICATION OF HILAR (KLATSKIN) CHOLANGIOCARCINOMAS: AN INVESTIGATION OF CODING PRACTICE IN THE UK, 45th Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S221-S221, ISSN: 0168-8278
Grellier J, Bennett J, Paterlarou E, et al., 2010, Exposure to disinfection by-products and adverse birth outcomes related to fetal growth and prematurity - a systematic review and meta-analysis., Epidemiology, Vol: 21, Pages: 300-313
Iszatt N, Nieuwenhuijsen MJ, Bennett J, et al., 2009, Trihalomethanes and Semen Quality in England and Wales, 21st Annual Conference of the International-Society-for-Environmental-Epidemiology, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S196-S196, ISSN: 1044-3983
Grellier J, Bennett J, Patelarou E, et al., 2009, Exposure to Disinfection By-Products and Adverse Birth Outcomes Related to Fetal Growth and Prematurity - A Systematic Review and Meta-Analysis, 21st Annual Conference of the International-Society-for-Environmental-Epidemiology, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S67-S67, ISSN: 1044-3983
- Author Web Link
- Cite
- Citations: 1
Iszatt N, Nieuwenhuijsen MJ, Toledano MB, et al., 2009, Water Consumption and Use, Trihalomethane Exposure and the Risk of Hypospadias, 21st Annual Conference of the International-Society-for-Environmental-Epidemiology, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S74-S74, ISSN: 1044-3983
Toledano MB, Bennett JE, Hambly P, et al., 2009, Chlorination Disinfection By-Products and Risk of Stillbirths in England and Wales, 21st Annual Conference of the International-Society-for-Environmental-Epidemiology, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S129-S129, ISSN: 1044-3983
Adenugba A, Khan SA, Taylor-Robinson SD, et al., 2009, Polychlorinated biphenyls in bile of patients with biliary tract cancer, CHEMOSPHERE, Vol: 76, Pages: 841-846, ISSN: 0045-6535
- Author Web Link
- Cite
- Citations: 13
Toledano MB, Mehtan A, Elliott P, et al., 2009, UPDATE OF INCIDENCE AND MORTALITY RATES AND REVIEW OF DIAGNOSTIC TRENDS FOR INTRAHEPATIC CHOLANGIOCARCINOMA AND SELECTED HEPATOBILIARY TUMOURS IN ENGLAND AND WALES, Annual Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A67-A67, ISSN: 0017-5749
Nassim P, Edwards RJ, Wasan H, et al., 2009, PLASMA PROTEOMIC PROFILING OF PATIENTS WITH CHOLANGIOCARCINOMA, Annual Meeting of the British-Society-of-Gastroenterology, Publisher: B M J PUBLISHING GROUP, Pages: A17-A17, ISSN: 0017-5749
Ormond G, Nieuwenhuijsen MJ, Nelson P, et al., 2009, Endocrine Disruptors in the Workplace, Hair Spray, Folate Supplementation, and Risk of Hypospadias: Case-Control Study, ENVIRONMENTAL HEALTH PERSPECTIVES, Vol: 117, Pages: 303-307, ISSN: 0091-6765
- Author Web Link
- Open Access Link
- Cite
- Citations: 123
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.