Publications
154 results found
Adenugba A, Khan SA, Taylor-Robinson SD, et al., 2009, POLYCHLORINATED BIPHENYLS IN BILE OF PATIENTS WITH BILIARY TRACT CANCER, 44th Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: S188-S188, ISSN: 0168-8278
Nieuwenhuijsen MJ, Smith R, Golfinopoulos S, et al., 2009, Health impacts of long-term exposure to disinfection by-products in drinking water in Europe: HIWATE., J Water Health, Vol: 7, Pages: 185-207
Nieuwenhuijsen MJ, Smith R, Golfinopoulos S, Best N, Bennett J, Aggazzotti G, Righi E, Fantuzzi G, Bucchini L, Cordier S, Villanueva CM, Moreno V, La Vecchia C, Bosetti C, Vartiainen T, Rautiu R, Toledano M, Iszatt N, Grazuleviciene R, Kogevinas M.
Parviz N, Edwards RJ, Wasan HS, et al., 2008, PLASMA PROTEOMIC PROFILING OF PATIENTS WITH CHOLANGIOCARCINOMA, 59th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, Publisher: JOHN WILEY & SONS INC, Pages: 984A-985A, ISSN: 0270-9139
Gomaa AI, Khan SA, Toledano MB, et al., 2008, Hepatocellular carcinoma: Epidemiology, risk factors and pathogenesis, WORLD JOURNAL OF GASTROENTEROLOGY, Vol: 14, Pages: 4300-4308, ISSN: 1007-9327
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- Citations: 518
Khan SA, Toledano MB, Taylor-Robinson SD, 2008, Epidemiology, risk factors and pathogenesis of cholangiocarcinoma, HPB, Vol: 10, Pages: 77-82
Nieuwenhuijsen MJ, Toledano MB, Bennett J, et al., 2007, Chlorination disinfection by-products and risk of congenital anomalies in England and Wales, Environmental Health Perspectives, Vol: 116, Pages: 216-222, ISSN: 0091-6765
BACKGROUND:Increased risk of various congenital anomalies has been reported to be associatedwith trihalomethane (THM) exposure in the water supply.OBJECTIVES:We conducted a registry-based study to determine the relationship between THMconcentrations and the risk of congenital anomalies in England and Wales. METHODS:We obtained congenital anomaly data from the National Congenital Anomalies System,regional registries, and the national terminations registry; THM data were obtained from watercompanies. Total THM (< 30, 30 to < 60, ≥60 μg/L), total brominated exposure (< 10, 10 to < 20,≥20 μg/L), and bromoform exposure (< 2, 2 to < 4, ≥4 μg/L) were modeled at the place of resi-dence for the first trimester of pregnancy. We included 2,605,226 live births, stillbirths, and termi-nations with 22,828 cases of congenital anomalies. Analyses using fixed- and random-effects modelswere performed for broadly defined groups of anomalies (cleft palate/lip, abdominal wall, majorcardiac, neural tube, urinary and respiratory defects), a more restricted set of anomalies with betterascertainment, and for isolated and multiple anomalies. Data were adjusted for sex, maternal age,and socioeconomic status. RESULTS:We found no statistically significant trends across exposure categories for either thebroadly defined or more restricted sets of anomalies. For the restricted set of anomalies with iso-lated defects, there were significant (p< 0.05) excess risks in the high-exposure categories of totalTHMs for ventricular septal defects [odds ratio (OR) = 1.43; 95% confidence interval (CI),1.00–2.04] and of bromoform for major cardiovascular defects and gastroschisis (OR = 1.18;95% CI, 1.00–1.39; and OR = 1.38; 95% CI, 1.00–1.92, respectively). CONCLUSION:In this large national study we found little evidence for a relationship between THMconcentrations in drinking water and risk of congenital anomalies.
Toledano MB, Nelson PD, 2007, Male fertility-related disorders: cause for concern or a stalking horse?, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 92, Pages: 565-567, ISSN: 0003-9888
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- Citations: 1
Nelson PD, Toledano MB, McConville J, et al., 2006, Trends in acoustic neuroma and cellular phones: Is there a link?, NEUROLOGY, Vol: 66, Pages: 284-285, ISSN: 0028-3878
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- Citations: 11
Nieuwenhuijsen MJ, Toledano MB, Konstantinou K, et al., 2005, Water chlorination by-products and congenital anomalies, 17th Annual Conference of the International-Society-for-Environmental-Epidemiology, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S81-S82, ISSN: 1044-3983
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- Citations: 1
Khan SA, Thomas HC, Toledano MB, et al., 2005, p53 mutations in human cholangiocarcinoma: a review, LIVER INTERNATIONAL, Vol: 25, Pages: 704-716, ISSN: 1478-3223
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- Citations: 65
Toledano MB, Shaddick G, Elliott P, 2005, Seasonal variations in all cause and cardiovascular mortality and the role of temperature, Coronary Heart Disease Epidemiology: from aetiology to public health. Second edition., Editors: Marmot, Elliott, Marmot, Elliott, Oxford, Publisher: Oxford University Press, Pages: 495-527, ISBN: 9780198568063
Khan SA, Mandeville K, Toledano MB, et al., 2005, Update of mortality and incidence rates for intrahepatic cholangiocarcinoma and other hepatobiliary tumours in England and Wales, 40th Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Publisher: ELSEVIER SCIENCE BV, Pages: 95-95, ISSN: 0168-8278
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- Citations: 1
Toledano MB, Nieuwenhuijsen MJ, Best N, et al., 2005, Relation of trihalomethane concentrations in public water supplies to stillbirth and birth weight in three water regions in England, ENVIRONMENTAL HEALTH PERSPECTIVES, Vol: 113, Pages: 225-232, ISSN: 0091-6765
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- Citations: 90
Toledano MB, Nieuwenhuijsen MJ, Best N, et al., 2004, Relation of individual trimalomethane concentrations in public water supplies to stillbirth and birth weight prevalence in three water regions, 16th Conference of the International-Society-for-Environmental-Epidemiology, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S105-S106, ISSN: 1044-3983
Toledano MB, Nieuwenhuijsen MJ, Best NG, et al., 2003, Chlorination disinfection by-products and adverse birth outcomes: A retrospective cohort study in three regions in England, 15th Conference of the International-Society-for-Environment-Epidemiology, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S39-S39, ISSN: 1044-3983
Toledano MB, Hansell AL, Jarup L, et al., 2003, Temporal trends in orchidopexy, Great Britain, 1992-1998, Environmental Health Perspectives, Vol: 111, Pages: 129-132, ISSN: 0091-6765
Concern has been expressed in recent years about worsening male reproductive health, possiblymediated by increasing exposures to environmental endocrine-disrupting agents. Trends suggestedlarge increases in cryptorchidism in Britain and the United States between the 1950s and 1980s,although published data on recent trends have been scarce. We examined numbers of orchidopexyprocedures, as a marker for cryptorchidism, using routine hospital admission data for England,Wales, and Scotland for fiscal years 1992–1993 through 1998–1999. Annual trends in orchidopexyrates were analyzed by age, in-patient admission versus day case, and geographical region.Orchidopexy rates were also obtained from the General Practice Research Database (GPRD) forEngland to cross-validate the hospital admissions data. Orchidopexy rates for boys 0–14 years oldfell by 33% (from 23.5 to 15.8 per 10,000 population) between 1992 and 1998, with the steepestdecline (50%) in 5–9-year-olds. The decreasing trend for 0–14-year-olds was evident in everyregion in England, in Wales, and in Scotland. Rates remained stable for men 15 or more years old,at 0.7 per 10,000. There was a marked shift from in-patient to day-case procedures. Rates fromthe GPRD showed a similar downward trend to the hospital data. Our findings could representeither an underlying decrease in the frequency of undescended testis or a fairly dramatic improvementin the diagnosis of cryptorchidism—resulting in fewer orchidopexies performed for retractiletestis—in Great Britain during the 1990s, or both. Either way, our findings do not support thepostulate of a recent worsening of male reproductive health of the scale suggested by some recentcommentators on the endocrine disruptor hypothesis. Key words: cryptorchidism, endocrine,orchidopexy, routine health data, temporal trends, testes
Khan SA, Taylor-Robinson SD, Toledano MB, et al., 2002, Changing international trends in mortality rates for liver, biliary and pancreatic tumours, JOURNAL OF HEPATOLOGY, Vol: 37, Pages: 806-813, ISSN: 0168-8278
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- Citations: 439
Toledano MB, Nieuwenhuijsen MJ, Bennett J, et al., 2002, Chlorination disinfection by-products and adverse birth outocmes in Great Britain: Birthweight and still birth., EPIDEMIOLOGY, Vol: 13, Pages: S111-S111, ISSN: 1044-3983
Jarup L, Best N, Toledano MB, et al., 2002, Geographical epidemiology of prostate cancer in Great Britain, INTERNATIONAL JOURNAL OF CANCER, Vol: 97, Pages: 695-699, ISSN: 0020-7136
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- Citations: 42
Keegan T, Whitaker H, Nieuwenhuijsen MJ, et al., 2001, Use of routinely collected data on trihalomethane in drinking water for epidemiological purposes, OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, Vol: 58, Pages: 447-452, ISSN: 1351-0711
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- Citations: 40
Toledano MB, Nieuwenhuijsen MJ, Bennett J, et al., 2001, Chlorination disinfection by-products and adverse birth outcomes in Great Britain: Birthweight and still birth, EPIDEMIOLOGY, Vol: 12, Pages: S62-S62, ISSN: 1044-3983
Toledano MB, Jarup L, Best N, et al., 2001, Spatial variation and temporal trends of testicular cancer in Great Britain, BRITISH JOURNAL OF CANCER, Vol: 84, Pages: 1482-1487, ISSN: 0007-0920
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- Citations: 34
Taylor-Robinson SD, Toledano MB, Arora S, et al., 2001, Increase in mortality rates from intrahepatic cholangiocarcinoma in England and Wales 1968-1998, GUT, Vol: 48, Pages: 816-820, ISSN: 0017-5749
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- Citations: 317
Khan SA, Taylor-Robinson SD, Toledano MB, et al., 2001, Worldwide trends in mortality rates for hepatobiliary and pancreatic tumours, 1979-1997, GUT, Vol: 48, Pages: A103-A103, ISSN: 0017-5749
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- Citations: 1
Nieuwenhuijsen MJ, Toledano MB, Elliott P, 2000, Uptake of chlorination disinfection by-products; a review and a discussion of its implications for exposure assessment in epidemiological studies, JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY, Vol: 10, Pages: 586-599, ISSN: 1053-4245
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- Citations: 142
Khan SA, Taylor-Robinson SD, Toledano MB, et al., 2000, Comparison of trends in mortality rates rates for primary liver tumours worldwide 1979-1997., HEPATOLOGY, Vol: 32, Pages: 228A-228A, ISSN: 0270-9139
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- Citations: 1
Toledano MB, Jarup L, Wallace C, et al., 2000, Geographical epidemiology of prostate and testic ular cancer in Great Britain, EPIDEMIOLOGY, Vol: 11, Pages: S112-S112, ISSN: 1044-3983
Toledano MB, Elliott P, Nieuwenhuijsen MJ, et al., 2000, A retrospective cohort study of water disinfection by-products and adverse human birth outcomes in Great Britain, EPIDEMIOLOGY, Vol: 11, Pages: S110-S110, ISSN: 1044-3983
Toledano MB, Jarup L, Wakefield J, et al., 2000, Spatial and temporal variation of orchidopexy, as a proxy for cryptorchidism, using hospital admissions data for England and Scotland, 1992-1996, EPIDEMIOLOGY, Vol: 11, Pages: S111-S111, ISSN: 1044-3983
Khan SA, Taylor-Robinson SD, Toledano MB, et al., 2000, Increase in mortality rates for intrahepatic cholangiocarcinoma in England & Wales 1968-1996, GUT, Vol: 46, Pages: A74-A74, ISSN: 0017-5749
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