Imperial College London
Portrait Picture

Professor Mireille B Toledano

Faculty of Medicine, School of Public Health

Mohn Chair; Population Child Health & Director-Mohn Centre
 
 
 
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Contact

 

m.toledano Website

 
 
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Location

 

525Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Maitre:2018:10.1021/acs.est.8b02215,
author = {Maitre, L and Robinson, O and Martinez, D and Toledano, MB and Ibarluzea, J and Santa, Marina L and Sunyer, J and Villanueva, CM and Keun, HC and Vrijheid, M and Coen, M},
doi = {10.1021/acs.est.8b02215},
journal = {Environmental Science and Technology},
pages = {13469--13480},
title = {Urine metabolic signatures of multiple environmental pollutants in pregnant women - an exposome approach},
url = {http://dx.doi.org/10.1021/acs.est.8b02215},
volume = {52},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Exposure to environmental pollutants, particularly during pregnancy, can have adverse consequences on child development but little is known about the effects of pollutant mixtures on endogenous metabolism in pregnant women. We aimed to identify urinary metabolic signatures associated with low level exposure to multiple environmental pollutants in pregnant women from the INMA (INfancia y Medio Ambiente) birth cohort (Spain, N = 750). 35 chemical exposures were quantified in first trimester blood samples (organochlorine pesticides, PCBs, PFAS), in cord blood (mercury), and twice in urine at 12 and 32 weeks of pregnancy (metals, phthalates, bisphenol A). 1H nuclear magnetic resonance (NMR) metabolic profiles of urine were acquired in the same samples as pollutants. We explored associations between exposures and metabolism through an exposome-metabolome wide association scan and multivariate O2PLS modeling. Novel and reproducible associations were found across two periods of pregnancy for three nonpersistent pollutants and across two subcohorts for four of the persistent pollutants. We found novel metabolic signatures associated with arsenic exposure: TMAO and dimethylamine possibly related to gut microbial methylamine metabolism and homarine related to fish intake. Tobacco smoke exposure was related to coffee metabolism and PCBs with 3-hydroxyvaleric acid, usually released under ketoacidosis. These findings will have implications for further understanding of maternal-fetal health, and health across the life-course.
AU  - Maitre,L
AU  - Robinson,O
AU  - Martinez,D
AU  - Toledano,MB
AU  - Ibarluzea,J
AU  - Santa,Marina L
AU  - Sunyer,J
AU  - Villanueva,CM
AU  - Keun,HC
AU  - Vrijheid,M
AU  - Coen,M
DO  - 10.1021/acs.est.8b02215
EP  - 13480
PY  - 2018///
SN  - 0013-936X
SP  - 13469
TI  - Urine metabolic signatures of multiple environmental pollutants in pregnant women - an exposome approach
T2  - Environmental Science and Technology
UR  - http://dx.doi.org/10.1021/acs.est.8b02215
UR  - http://hdl.handle.net/10044/1/65243
VL  - 52
ER  -
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