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@article{Fernandes:2021:10.1186/s12889-021-11892-5,
author = {Fernandes, GS and Spiers, A and Vaidya, N and Zhang, Y and Sharma, E and Holla, B and Heron, J and Hickman, M and Murthy, P and Chakrabarti, A and Basu, D and Subodh, BN and Singh, L and Singh, R and Kalyanram, K and Kartik, K and Kumaran, K and Krishnaveni, G and Kuriyan, R and Kurpad, S and Barker, GJ and Bharath, RD and Desrivieres, S and Purushottam, M and Orfanos, DP and Toledano, MB and Schumann, G and Benegal, V},
doi = {10.1186/s12889-021-11892-5},
journal = {BMC Public Health},
title = {Adverse childhood experiences and substance misuse in young people in India: results from the multisite cVEDA cohort},
url = {http://dx.doi.org/10.1186/s12889-021-11892-5},
volume = {21},
year = {2021}
}

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TY  - JOUR
AB  - Background: Adverse childhood experiences (ACEs) increases vulnerability to externalising disorders such assubstance misuse. The study aims to determine the prevalence of ACEs and its association with substance misuse.Methods: Data from the Consortium on Vulnerability to Externalising Disorders and Addictions (cVEDA) in Indiawas used (n = 9010). ACEs were evaluated using the World Health Organisation (WHO) Adverse ChildhoodExperiences International Questionnaire whilst substance misuse was assessed using the WHO Alcohol, Smokingand Substance Involvement Screening Test. A random-effects, two-stage individual patient data meta-analysisexplained the associations between ACEs and substance misuse with adjustments for confounders such as sex andfamily structure.Results: 1 in 2 participants reported child maltreatment ACEs and family level ACEs. Except for sexual abuse, malesreport more of every individual childhood adversity and are more likely to report misusing substances comparedwith females (87.3% vs. 12.7%). In adolescents, family level ACEs (adj OR 4.2, 95% CI 1.5–11.7) and collective levelACEs (adj OR 6.6, 95% CI 1.4–31.1) show associations with substance misuse whilst in young adults, child level ACEssuch as maltreatment show similar strong associations (adj OR 2.0, 95% CI 1.1–3.5).Conclusion: ACEs such as abuse and domestic violence are strongly associated with substance misuse, mostcommonly tobacco, in adolescent and young adult males in India. The results suggest enhancing current ACEresilience programmes and ‘trauma-informed’ approaches to tackling longer-term impact of ACEs in India.Funding: Newton Bhabha Grant jointly funded by the Medical Research Council, UK (MR/N000390/1) and theIndian Council of Medical Research (ICMR/MRC-UK/3/M/2015-NCD-I).
AU  - Fernandes,GS
AU  - Spiers,A
AU  - Vaidya,N
AU  - Zhang,Y
AU  - Sharma,E
AU  - Holla,B
AU  - Heron,J
AU  - Hickman,M
AU  - Murthy,P
AU  - Chakrabarti,A
AU  - Basu,D
AU  - Subodh,BN
AU  - Singh,L
AU  - Singh,R
AU  - Kalyanram,K
AU  - Kartik,K
AU  - Kumaran,K
AU  - Krishnaveni,G
AU  - Kuriyan,R
AU  - Kurpad,S
AU  - Barker,GJ
AU  - Bharath,RD
AU  - Desrivieres,S
AU  - Purushottam,M
AU  - Orfanos,DP
AU  - Toledano,MB
AU  - Schumann,G
AU  - Benegal,V
DO  - 10.1186/s12889-021-11892-5
PY  - 2021///
SN  - 1471-2458
TI  - Adverse childhood experiences and substance misuse in young people in India: results from the multisite cVEDA cohort
T2  - BMC Public Health
UR  - http://dx.doi.org/10.1186/s12889-021-11892-5
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000710126900002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-021-11892-5
UR  - http://hdl.handle.net/10044/1/95304
VL  - 21
ER  -

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