Imperial College London
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Professor Mireille B Toledano

Faculty of Medicine, School of Public Health

Mohn Chair; Population Child Health & Director-Mohn Centre
 
 
 
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Contact

 

m.toledano Website

 
 
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Location

 

525Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Maitre:2016:10.1186/s12916-016-0706-3,
author = {Maitre, L and Villanueva, CM and Lewis, M and Ibarluzea, J and SantaMarina, L and Vrijheid, M and Sunyer, J and Coen, M and Toledano, MB},
doi = {10.1186/s12916-016-0706-3},
journal = {BMC Medicine},
title = {Maternal urinary metabolic signatures of fetal growth and associated clinical and environmental factors in the INMA study},
url = {http://dx.doi.org/10.1186/s12916-016-0706-3},
volume = {14},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundMaternal metabolism during pregnancy is a major determinant of the intra-uterine environment and fetal outcomes. Herein, we characterize the maternal urinary metabolome throughout pregnancy to identify maternal metabolic signatures of fetal growth in two subcohorts and explain potential sources of variation in metabolic profiles based on lifestyle and clinical data.MethodsWe used 1H nuclear magnetic resonance (NMR) spectroscopy to characterize maternal urine samples collected in the INMA birth cohort at the first (n = 412 and n = 394, respectively, in Gipuzkoa and Sabadell cohorts) and third trimesters of gestation (n = 417 and 469). Metabolic phenotypes that reflected longitudinal intra- and inter-individual variation were used to predict measures of fetal growth and birth weight.ResultsA metabolic shift between the first and third trimesters of gestation was characterized by 1H NMR signals arising predominantly from steroid by-products. We identified 10 significant and reproducible metabolic associations in the third trimester with estimated fetal, birth, and placental weight in two independent subcohorts. These included branched-chain amino acids; isoleucine, valine, leucine, alanine and 3 hydroxyisobutyrate (metabolite of valine), which were associated with a significant fetal weight increase at week 34 of up to 2.4 % in Gipuzkoa (P < 0.005) and 1 % in Sabadell (P < 0.05). Other metabolites included pregnancy-related hormone by-products of estrogens and progesterone, and the methyl donor choline. We could explain a total of 48–53 % of the total variance in birth weight of which urine metabolites had an independent predictive power of 12 % adjusting for all other lifestyle/clinical factors. First trimester metabolic phenotypes could not predict reproducibly weight at later stages of development. Physical activity, as well as other modifiable lifestyle/clinical factors, suc
AU  - Maitre,L
AU  - Villanueva,CM
AU  - Lewis,M
AU  - Ibarluzea,J
AU  - SantaMarina,L
AU  - Vrijheid,M
AU  - Sunyer,J
AU  - Coen,M
AU  - Toledano,MB
DO  - 10.1186/s12916-016-0706-3
PY  - 2016///
SN  - 1741-7015
TI  - Maternal urinary metabolic signatures of fetal growth and associated clinical and environmental factors in the INMA study
T2  - BMC Medicine
UR  - http://dx.doi.org/10.1186/s12916-016-0706-3
UR  - http://hdl.handle.net/10044/1/41494
VL  - 14
ER  -
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