Marco Trizzino is a Senior Lecturer in the Department of Life Sciences.
For more information about the lab visit our Lab Website
PhD: Department of Biology and Biotechnology, Sapienza University, Rome, Italy
Postdoctoral Training: Department of Genetics at the University of Pennsylvania, and Gene Expression and Regulation Program at The Wistar Institute, Philadelphia, PA, USA
We use an integrated approach, including both experimental and computational genomics to investigate a wide range of questions in developmental and evolutionary genomics.
In particular, we are keen on elucidating:
1) How a very recent genomic invasion by young transposable elements has contributed to the evolution of human-specific traits by establishing novel developmental gene regulatory networks;
2) Why mutations in genes encoding for chromatin associated proteins lead to developmental syndromes which manifest with impaired craniofacial and neural development;
3) Why some mammalian species live longer than others.
We use induced Pluripotent Stem Cells (iPSCs) derived from multiple primate species, as well as from patients affected by neurodevelopmental syndromes and neurodegenerative disorders. We differentiate the iPSCs in multiple neuronal and neural crest lineages, and complement this approach with functional and computational genomics.
et al., 2023, JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer’s disease, Nature Communications, Vol:14, ISSN:2041-1723
et al., 2022, Young transposable elements rewired gene regulatory networks in human and chimpanzee hippocampal intermediate progenitors, Development, Vol:149, ISSN:0950-1991
et al., 2022, Genomic features underlie the co-option of SVA transposons as cis-regulatory elements in human pluripotent stem cells, Plos Genetics, Vol:18, ISSN:1553-7390
et al., 2022, Targeting chemotherapy to decondensed H3K27me3-marked chromatin of AML cells enhances Leukemia suppression, Cancer Research, Vol:82, ISSN:0008-5472, Pages:458-471
et al., 2022, Positive selection and enhancer evolution shaped lifespan and body mass in great apes, Molecular Biology and Evolution, Vol:39, ISSN:0737-4038