Imperial College London
Alternate

DrMartinWalker

Faculty of Medicine, School of Public Health

Honorary Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3229m.walker06 CV

 
 
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Location

 

G2716 South Wharf RoadSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dixon:2020:10.1038/s41598-020-74007-x,
author = {Dixon, MA and Winskill, P and Harrison, W and Whittaker, C and Schmidt, V and Sarti, E and Bawm, S and Dione, MM and Thomas, LF and Walker, M and Basanez, M-G},
doi = {10.1038/s41598-020-74007-x},
journal = {Scientific Reports},
title = {Force-of-Infection of Taenia solium porcine cysticercosis: a modelling analysis to assess global incidence and prevalence trends},
url = {http://dx.doi.org/10.1038/s41598-020-74007-x},
volume = {10},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The World Health Organization (WHO) called, in 2012, for a validated strategy towards Taenia solium taeniasis/cysticercosis control and elimination. Estimating pig force-of-infection (FoI, the average rate at which susceptible pigs become infected) across geographical settings will help understand local epidemiology and inform effective intervention design. Porcine cysticercosis (PCC) age-prevalence data (from 15 studies in Latin America, Africa and Asia) were identified through systematic review. Catalytic models were fitted to the data using Bayesian methods, incorporating uncertainty in diagnostic performance, to estimate rates of antibody seroconversion, viable metacestode acquisition, and seroreversion/infection loss. There was evidence of antibody seroreversion across 5 studies, and of infection loss in 6 studies measured by antigen or necropsy, indicating transient serological responses and natural resolution of infection. Concerted efforts should be made to collect robust data using improved diagnostics to better understand geographical heterogeneities in T. solium transmission to support post-2020 WHO targets.
AU  - Dixon,MA
AU  - Winskill,P
AU  - Harrison,W
AU  - Whittaker,C
AU  - Schmidt,V
AU  - Sarti,E
AU  - Bawm,S
AU  - Dione,MM
AU  - Thomas,LF
AU  - Walker,M
AU  - Basanez,M-G
DO  - 10.1038/s41598-020-74007-x
PY  - 2020///
SN  - 2045-2322
TI  - Force-of-Infection of Taenia solium porcine cysticercosis: a modelling analysis to assess global incidence and prevalence trends
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-020-74007-x
UR  - http://hdl.handle.net/10044/1/83544
VL  - 10
ER  -
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