Imperial College London
Alternate

DrMartinWalker

Faculty of Medicine, School of Public Health

Honorary Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3229m.walker06 CV

 
 
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Location

 

G2716 South Wharf RoadSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fall:2021:10.3390/microorganisms9081776,
author = {Fall, CB and Lambert, S and Leger, E and Yasenev, L and Garba, AD and Diop, SD and Borlase, A and Catalano, S and Faye, B and Walker, M and Sene, M and Webster, JP},
doi = {10.3390/microorganisms9081776},
journal = {Microorganisms},
pages = {1--18},
title = {Hybridized zoonotic schistosoma infections result in hybridized morbidity profiles: a clinical morbidity study amongst co-infected human populations of Senegal},
url = {http://dx.doi.org/10.3390/microorganisms9081776},
volume = {9},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Hybridization of infectious agents is a major emerging public and veterinary health concern at the interface of evolution, epidemiology, and control. Whilst evidence of the extent of hybridization amongst parasites is increasing, their impact on morbidity remains largely unknown. This may be predicted to be particularly pertinent where parasites of animals with contrasting pathogenicity viably hybridize with human parasites. Recent research has revealed that viable zoonotic hybrids between human urogenital Schistosoma haematobium with intestinal Schistosoma species of livestock, notably Schistosoma bovis, can be highly prevalent across Africa and beyond. Examining human populations in Senegal, we found increased hepatic but decreased urogenital morbidity, and reduced improvement following treatment with praziquantel, in those infected with zoonotic hybrids compared to non-hybrids. Our results have implications for effective monitoring and evaluation of control programmes, and demonstrate for the first time the potential impact of parasite hybridizations on host morbidity.
AU  - Fall,CB
AU  - Lambert,S
AU  - Leger,E
AU  - Yasenev,L
AU  - Garba,AD
AU  - Diop,SD
AU  - Borlase,A
AU  - Catalano,S
AU  - Faye,B
AU  - Walker,M
AU  - Sene,M
AU  - Webster,JP
DO  - 10.3390/microorganisms9081776
EP  - 18
PY  - 2021///
SN  - 2076-2607
SP  - 1
TI  - Hybridized zoonotic schistosoma infections result in hybridized morbidity profiles: a clinical morbidity study amongst co-infected human populations of Senegal
T2  - Microorganisms
UR  - http://dx.doi.org/10.3390/microorganisms9081776
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000689444000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.mdpi.com/2076-2607/9/8/1776
UR  - http://hdl.handle.net/10044/1/91499
VL  - 9
ER  -
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