Imperial College London
Alternate

DrMartinWalker

Faculty of Medicine, School of Public Health

Honorary Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3229m.walker06 CV

 
 
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Location

 

G2716 South Wharf RoadSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dixon-Zegeye:2022:10.7554/eLife.76988,
author = {Dixon-Zegeye, M and Winskill, P and Harrison, W and Whittaker, C and Schmidt, V and Flórez, Sánchez A and Cucunubá, Perez ZM and Edia-Asuke, A and Walker, M and Basanez, M-G},
doi = {10.7554/eLife.76988},
journal = {eLife},
title = {Global force-of-infection trends for human taenia solium taeniasis/cysticercosis},
url = {http://dx.doi.org/10.7554/eLife.76988},
volume = {11},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Infection by Taenia solium poses a major burden across endemic countries. The World Health Organization (WHO) 2021–2030 Neglected Tropical Diseases roadmap has proposed that 30% of endemic countries achieve intensified T. solium control in hyperendemic areas by 2030. Understanding geographical variation in age-prevalence profiles and force-of-infection (FoI) estimates will inform intervention designs across settings. Human taeniasis (HTT) and human cysticercosis (HCC) age-prevalence data from 16 studies in Latin America, Africa and Asia were extracted through a systematic review. Catalytic models, incorporating diagnostic performance uncertainty, were fitted to the data using Bayesian methods, to estimate rates of antibody (Ab)-seroconversion, infection acquisition and Ab-seroreversion or infection loss. HCC FoI and Ab-seroreversion rates were also estimated across 23 departments in Colombia from 28,100 individuals. Across settings, there was extensive variation in all-ages seroprevalence. Evidence for Ab seroreversion or infection loss was found in most settings for both HTT and HCC and for HCC Ab seroreversion in Colombia. The average duration until humans became Ab-seropositive/infected decreased as all-age (sero)prevalence increased. There was no clear relationship between the average duration humans remain Ab-seropositive and all-age seroprevalence. Marked geographical heterogeneity in T. solium transmission rates indicate the need for setting43 specific intervention strategies to achieve the WHO goals.
AU  - Dixon-Zegeye,M
AU  - Winskill,P
AU  - Harrison,W
AU  - Whittaker,C
AU  - Schmidt,V
AU  - Flórez,Sánchez A
AU  - Cucunubá,Perez ZM
AU  - Edia-Asuke,A
AU  - Walker,M
AU  - Basanez,M-G
DO  - 10.7554/eLife.76988
PY  - 2022///
SN  - 2050-084X
TI  - Global force-of-infection trends for human taenia solium taeniasis/cysticercosis
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.76988
UR  - http://hdl.handle.net/10044/1/98977
VL  - 11
ER  -
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