Imperial College London
Alternate

DrMartinWalker

Faculty of Medicine, School of Public Health

Honorary Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3229m.walker06 CV

 
 
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Location

 

G2716 South Wharf RoadSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Walker:2023:10.3389/fmed.2023.1092030,
author = {Walker, M and Lambert, S and Neves, MI and Worsley, AD and Traub, R and Colella, V},
doi = {10.3389/fmed.2023.1092030},
journal = {Frontiers of Medicine},
title = {Modeling the effectiveness of One Health interventions against the zoonotic hookworm Ancylostoma ceylanicum},
url = {http://dx.doi.org/10.3389/fmed.2023.1092030},
volume = {10},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Hookworm disease is a major global public health concern, annually affecting 500-700 million of the world's poorest people. The World Health Organization is targeting the elimination of hookworm as a public health problem by 2030 using a strategy of mass drug administration (MDA) to at-risk human populations. However, in Southeast Asia and the Pacific the zoonotic hookworm species, Ancylostoma ceylanicum, is endemic in dogs and commonly infects people. This presents a potential impediment to the effectiveness of MDA that targets only humans. Here, we develop a novel multi-host (dog and human) transmission model of A. ceylanicum and compare the effectiveness of human-only and "One Health" (human plus dog) MDA strategies under a range of eco-epidemiological assumptions. We show that One Health interventions-targeting both dogs and humans-could suppress prevalence in humans to ≤ 1% by the end of 2030, even with only modest coverage (25-50%) of the animal reservoir. With increasing coverage, One Health interventions may even interrupt transmission. We discuss key unresolved questions on the eco-epidemiology of A. ceylanicum, the challenges of delivering MDA to animal reservoirs, and the growing importance of One Health interventions to human public health.
AU  - Walker,M
AU  - Lambert,S
AU  - Neves,MI
AU  - Worsley,AD
AU  - Traub,R
AU  - Colella,V
DO  - 10.3389/fmed.2023.1092030
PY  - 2023///
SN  - 1673-7342
TI  - Modeling the effectiveness of One Health interventions against the zoonotic hookworm Ancylostoma ceylanicum
T2  - Frontiers of Medicine
UR  - http://dx.doi.org/10.3389/fmed.2023.1092030
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36960338
UR  - http://hdl.handle.net/10044/1/103362
VL  - 10
ER  -
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