Professor Martin Wilkins

Rhodes CJ, Wharton J, Howard L, Gibbs JSR, Vonk-Noordegraaf A, Wilkins MRet al., 2011, Iron deficiency in pulmonary arterial hypertension: a potential therapeutic target, EUROPEAN RESPIRATORY JOURNAL, Vol: 38, Pages: 1453-1460, ISSN: 0903-1936

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• Citations: 75

Nasim MT, Ogo T, Ahmed M, Randall R, Chowdhury HM, Snape KM, Bradshaw TY, Southgate L, Lee GJ, Jackson I, Lord GM, Gibbs JSR, Wilkins MR, Ohta-Ogo K, Nakamura K, Girerd B, Coulet F, Soubrier F, Humbert M, Morrell NW, Trembath RC, Machado RDet al., 2011, Molecular genetic characterization of SMAD signaling molecules in pulmonary arterial hypertension, HUMAN MUTATION, Vol: 32, Pages: 1385-1389, ISSN: 1059-7794

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• Citations: 119

Zhai Z, Murphy K, Tighe H, Wang C, Wilkins MR, Gibbs JSR, Howard LSet al., 2011, Differences in Ventilatory Inefficiency Between Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension, CHEST, Vol: 140, Pages: 1284-1291, ISSN: 0012-3692

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• Citations: 75

Schermuly RT, Ghofrani HA, Wilkins MR, Grimminger Fet al., 2011, Mechanisms of disease: pulmonary arterial hypertension, Nature Reviews Cardiology, Vol: 8, Pages: 443-455, ISSN: 1759-5002

Our understanding of, and approach to, pulmonary arterial hypertension has undergone a paradigm shift in the past decade. Once a condition thought to be dominated by increased vasoconstrictor tone and thrombosis, pulmonary arterial hypertension is now seen as a vasculopathy in which structural changes driven by excessive vascular cell growth and inflammation, with recruitment and infiltration of circulating cells, play a major role. Perturbations of a number of molecular mechanisms have been described, including pathways involving growth factors, cytokines, metabolic signaling, elastases, and proteases, that may underlie the pathogenesis of the disease. Elucidating their contribution to the pathophysiology of pulmonary arterial hypertension could offer new drug targets. The role of progenitor cells in vascular repair is also under active investigation. The right ventricular response to increased pressure load is recognized as critical to survival and the molecular mechanisms involved are attracting increasing interest. The challenge now is to integrate this new knowledge and explore how it can be used to categorize patients by molecular phenotype and tailor treatment more effectively.

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Rhodes CJ, Howard LS, Busbridge M, Ashby D, Kondili E, Gibbs JSR, Wharton J, Wilkins MRet al., 2011, Iron Deficiency and Raised Hepcidin in Idiopathic Pulmonary Arterial Hypertension Clinical Prevalence, Outcomes, and Mechanistic Insights, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 58, Pages: 300-309, ISSN: 0735-1097

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• Citations: 181

Rhodes CJ, Wharton J, Howard LS, Gibbs JSR, Wilkins MRet al., 2011, Red cell distribution width outperforms other potential circulating biomarkers in predicting survival in idiopathic pulmonary arterial hypertension, HEART, Vol: 97, Pages: 1054-1060, ISSN: 1355-6037

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• Citations: 145

Zhao L, Zhai Z, Wharton J, Wilkins MRet al., 2011, Phosphodiesterase inhibitors in the treatment of pulmonary hypertension, Textbook of pulmonary vascular disease, Editors: Yuan, Garcia, Hales, Rich, Archer, West, Publisher: Springer, Pages: 1477-1486

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Abdul-Salam VB, Wharton J, Cupitt J, Berryman M, Edwards RJ, Wilkins MRet al., 2010, Proteomic Analysis of Lung Tissues From Patients With Pulmonary Arterial Hypertension, CIRCULATION, Vol: 122, Pages: 2058-U282, ISSN: 0009-7322

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Wilkins MR, Ali O, Bradlow W, Wharton J, Taegtmeyer A, Rhodes CJ, Ghofrani HA, Howard L, Nihoyannopoulos P, Mohiaddin RH, Gibbs JSRet al., 2010, Simvastatin as a Treatment for Pulmonary Hypertension Trial, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 181, Pages: 1106-1113, ISSN: 1073-449X

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• Citations: 99

Archer SL, Weir EK, Wilkins MR, 2010, Basic Science of Pulmonary Arterial Hypertension for Clinicians New Concepts and Experimental Therapies, CIRCULATION, Vol: 121, Pages: 2045-U175, ISSN: 0009-7322

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• Citations: 382

Wilkins MR, Wharton J, Zhao L, 2010, What animal models tell us about treatments of pulmonary hypertension, Pulmonary arterial hypertension, Editors: Antel, Hesselink, Schermuly, Pages: 57-69

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Zhao L, Sebkhi A, Ali O, Wojciak-Stothard B, Mamanova L, Yang Q, Wharton J, Wilkins MRet al., 2009, Simvastatin and sildenafil combine to attenuate pulmonary hypertension, EUROPEAN RESPIRATORY JOURNAL, Vol: 34, Pages: 948-957, ISSN: 0903-1936

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• Citations: 43

Rhodes CJ, Davidson A, Gibbs JSR, Wharton J, Wilkins MRet al., 2009, Therapeutic targets in pulmonary arterial hypertension, PHARMACOLOGY & THERAPEUTICS, Vol: 121, Pages: 69-88, ISSN: 0163-7258

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• Citations: 71

Baliga RS, Zhao L, Madhani M, Lopez-Torondel B, Visintin C, Selwood D, Wilkins MR, MacAllister RJ, Hobbs AJet al., 2008, Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 178, Pages: 861-869, ISSN: 1073-449X

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• Citations: 48

Michelakis ED, Wilkins MR, Rabinovitch M, 2008, Emerging concepts and translational priorities in pulmonary arterial hypertension, CIRCULATION, Vol: 118, Pages: 1486-1495, ISSN: 0009-7322

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• Citations: 114

Nickel N, Kempf T, Tapken H, Tongers J, Laenger F, Lehmann U, Golpon H, Olsson K, Wilkins MR, Gibbs JSR, Hoeper MM, Wollert KCet al., 2008, Growth differentiation factor-15 in idiopathic pulmonary arterial hypertension, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 178, Pages: 534-541, ISSN: 1073-449X

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• Citations: 111

Wilkins MR, Wharton J, Grimminger F, Ghofrani HAet al., 2008, Phosphodiesterase inhibitors for the treatment of pulmonary hypertension, EUROPEAN RESPIRATORY JOURNAL, Vol: 32, Pages: 198-209, ISSN: 0903-1936

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• Citations: 119

Diller G-P, van Eijl S, Okonko DO, Howard LS, Ali O, Thum T, Wort SJ, Bedard E, Gibbs JSR, Bauersachs J, Hobbs AJ, Wilkins MR, Gatzoulis MA, Wharton Jet al., 2008, Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension, CIRCULATION, Vol: 117, Pages: 3020-3030, ISSN: 0009-7322

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• Citations: 171

Gibbs JSR, 2008, Consensus statement on the management of pulmonary hypertension in clinical practice in the UK and Ireland, HEART, Vol: 94, ISSN: 1355-6037

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• Citations: 7

Bogle R, Wilkins M, 2007, Treating acute myocardial infarction: something in the wind?, LANCET, Vol: 370, Pages: 1461-1462, ISSN: 0140-6736

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• Citations: 2

Ali O, Wharton J, Simon J, Gibbs R, Howard L, Wilkins MRet al., 2007, Emerging therapies for pulmonary arterial hypertension, EXPERT OPINION ON INVESTIGATIONAL DRUGS, Vol: 16, Pages: 803-818, ISSN: 1354-3784

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• Citations: 12

Kojonazarov BK, Imanov BZ, Amatov TA, Mirrakhimov MM, Naeije R, Wilkins MR, Aldashev AAet al., 2007, Noninvasive and invasive evaluation of pulmonary arterial pressure in highlanders, EUROPEAN RESPIRATORY JOURNAL, Vol: 29, Pages: 352-356, ISSN: 0903-1936

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• Citations: 24

Zhao L, Bahaa F, Wilkins M, 2007, Tetrarydrobiopterin and pulmonary hypertension, PROBLEMS OF HIGH ALTITUDE MEDICINE AND BIOLOGY, Pages: 69-+, ISSN: 1874-6489

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Machado RD, Koehler R, Glissmeyer E, Veal C, Suntharalingam J, Kim M, Carlquist J, Town M, Elliott CG, Hoeper M, Fijalkowska A, Kurzyna M, Thomson JR, Gibbs SR, Wilkins MR, Seeger W, Morrell NW, Gruenig E, Trembath RC, Janssen Bet al., 2006, Genetic association of the serotonin transporter in pulmonary arterial hypertension, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 173, Pages: 793-797, ISSN: 1073-449X

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• Citations: 65

Abdul-Salam VB, Paul GA, Ali JO, Gibbs SR, Rahman D, Taylor GW, Wilkins MR, Edwards RJet al., 2006, Identification of plasma protein biomarkers associated with idiopathic pulmonary arterial hypertension, PROTEOMICS, Vol: 6, Pages: 2286-2294, ISSN: 1615-9853

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Aldashev AA, Kojonazarov BK, Amatov TA, Sooronbaev TM, Mirrakhimov MM, Morrell NW, Wharton J, Wilkins MRet al., 2005, Phosphodiesterase type 5 and high altitude pulmonary hypertension, THORAX, Vol: 60, Pages: 683-687, ISSN: 0040-6376

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• Citations: 74

Wharton J, Strange JW, Moller GMO, Growcott EJ, Ren XH, Franklyn AP, Phillips SC, Wilkins MRet al., 2005, Antiproliferative effects of phosphodiesterase type 5 inhibition in human pulmonary artery cells, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 172, Pages: 105-113, ISSN: 1073-449X

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• Citations: 272

Paul GA, Gibbs JSR, Boobis AR, Abbas A, Wilkins MRet al., 2005, Bosentan decreases the plasma concentration of sildenafil when coprescribed in pulmonary hypertension, BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 60, Pages: 107-112, ISSN: 0306-5251

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• Citations: 174

Wilkins MR, Paul GA, Strange JW, Tunariu N, Gin-Sing W, Banya WA, Westwood MA, Stefanidis A, Ng LL, Pennell DJ, Mohiaddin RH, Nihoyannopoulos P, Gibbs JSRet al., 2005, Sildenafil versus endothelin receptor antagonist for pulmonary hypertension (SERAPH) study, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 171, Pages: 1292-1297, ISSN: 1073-449X

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• Citations: 288

Khoo JP, Zhao L, Alp NJ, Bendall JK, Nicoli T, Rockett K, Wilkins MR, Channon KMet al., 2005, Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension, CIRCULATION, Vol: 111, Pages: 2126-2133, ISSN: 0009-7322

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• Citations: 122