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@article{Sofianopoulou:2019:10.1183/13993003.01429-2018,
author = {Sofianopoulou, E and Kaptoge, S and Gräf, S and Hadinnapola, C and Treacy, CM and Church, C and Coghlan, G and Gibbs, JSR and Haimel, M and Howard, L and Johnson, M and Kiely, DG and Lawrie, A and Lordan, J and MacKenzie, Ross RV and Martin, JM and Moledina, S and Newnham, M and Peacock, AJ and Price, L and Rhodes, CJ and Suntharalingam, J and Swietlik, EM and Toshner, MR and Wharton, J and Wilkins, MR and Wort, SJ and Pepke-Zaba, J and Condliffe, R and Corris, PA and Di, Angelantonio E and Provencher, S and Morrell, NW},
doi = {10.1183/13993003.01429-2018},
journal = {European Respiratory Journal},
pages = {1--12},
title = {Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: A United Kingdom cohort study analysis.},
url = {http://dx.doi.org/10.1183/13993003.01429-2018},
volume = {53},
year = {2019}
}

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TY  - JOUR
AB  - While traffic and air pollution exposure is associated with increased mortality in numerous diseases, its association with disease severity and outcomes in pulmonary arterial hypertension (PAH) remains unknown.Exposure to particulate matter ≤2.5μm3 (PM2.5), nitrogen dioxide (NO2) and indirect measures of traffic-related air pollution (distance to main road and length of roads within buffer zones surrounding residential addresses) were estimated for 301 patients with idiopathic/heritable PAH recruited in the UK PAH national Cohort study. Associations with transplant-free survival and pulmonary hemodynamic severity at baseline were assessed, adjusting for confounding variables defined a priori.Higher estimated exposure to PM2.5 was associated with higher risk of death or lung transplant (Unadjusted hazard ratio (HR) 2.68; 95% CI 1.11-6.47 per 3μg·m-3, p=0.028). This association remained similar when adjusted for potential confounding variables (HR 4.38; 95% CI 1.44-13.36 per 3μg·m-3, p=0.009). No associations were found between NO2 exposure or other traffic pollution indicators and transplant-free survival Conversely, indirect measures of exposure to traffic-related air pollution within the 500-1000m buffer zones correlated with the ERS/ESC risk categories as well as pulmonary hemodynamics at baseline. This association was strongest for pulmonary vascular resistance.In idiopathic/heritable PAH, indirect measures of exposure to traffic-related air pollution were associated with disease severity at baseline, whereas higher PM2.5 exposure may independently predict shorter transplant-free survival.
AU  - Sofianopoulou,E
AU  - Kaptoge,S
AU  - Gräf,S
AU  - Hadinnapola,C
AU  - Treacy,CM
AU  - Church,C
AU  - Coghlan,G
AU  - Gibbs,JSR
AU  - Haimel,M
AU  - Howard,L
AU  - Johnson,M
AU  - Kiely,DG
AU  - Lawrie,A
AU  - Lordan,J
AU  - MacKenzie,Ross RV
AU  - Martin,JM
AU  - Moledina,S
AU  - Newnham,M
AU  - Peacock,AJ
AU  - Price,L
AU  - Rhodes,CJ
AU  - Suntharalingam,J
AU  - Swietlik,EM
AU  - Toshner,MR
AU  - Wharton,J
AU  - Wilkins,MR
AU  - Wort,SJ
AU  - Pepke-Zaba,J
AU  - Condliffe,R
AU  - Corris,PA
AU  - Di,Angelantonio E
AU  - Provencher,S
AU  - Morrell,NW
DO  - 10.1183/13993003.01429-2018
EP  - 12
PY  - 2019///
SN  - 0903-1936
SP  - 1
TI  - Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: A United Kingdom cohort study analysis.
T2  - European Respiratory Journal
UR  - http://dx.doi.org/10.1183/13993003.01429-2018
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30923185
UR  - https://erj.ersjournals.com/content/53/5/1801429
VL  - 53
ER  -

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