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BibTex format

@article{Wilkins:2020:10.21542/gcsp.2020.7,
author = {Wilkins, M},
doi = {10.21542/gcsp.2020.7},
journal = {Global Cardiology Science & Practice},
pages = {e202007--e202007},
title = {Pulmonary hypertension: proteins in the blood},
url = {http://dx.doi.org/10.21542/gcsp.2020.7},
volume = {2020},
year = {2020}
}

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TY  - JOUR
AB  - The plasma proteome is rich in information. It comprises proteins that are secreted or lost from cells as they respond to their local environment. Changes in the constitution of the plasma proteome offer a relatively non-invasive report on the health of tissues. This is particularly true of the lung in pulmonary hypertension, given the large surface area of the pulmonary vasculature in direct communication with blood. So far, this is relatively untapped; we have relied on proteins released from the heart, specifically brain natriuretic peptide and troponin, to inform clinical management. New technology allows the measurement of a larger number of proteins that cover a broad range of molecular pathways in a single small aliquot. The emerging data will yield more than just new biomarkers of pulmonary hypertension for clinical use. Integrated with genomics and with the help of new bioinformatic tools, the plasma proteome can provide insight into the causative drivers of pulmonary vascular disease and guide drug development.
AU  - Wilkins,M
DO  - 10.21542/gcsp.2020.7
EP  - 202007
PY  - 2020///
SN  - 2305-7823
SP  - 202007
TI  - Pulmonary hypertension: proteins in the blood
T2  - Global Cardiology Science & Practice
UR  - http://dx.doi.org/10.21542/gcsp.2020.7
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33178814
UR  - http://hdl.handle.net/10044/1/85267
VL  - 2020
ER  -

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Professor Martin Wilkins

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