Imperial College London
Portrait Picture

Professor Mark Wilson

Faculty of Medicine, Department of Surgery & Cancer

Professor of Practice
 
 
 
//

Contact

 

+44 (0)20 7594 1532m.wilson

 
 
//

Location

 

Cambridge WingSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Dixon:2020:10.1136/svn-2020-000652,
author = {Dixon, L},
doi = {10.1136/svn-2020-000652},
journal = {Stroke and Vascular Neurology},
pages = {315--322},
title = {Cerebral microhaemorrhage in COVID-19:  A critical illness related phenomenon?},
url = {http://dx.doi.org/10.1136/svn-2020-000652},
volume = {5},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundCerebral microhaemorrhages are increasingly being recognised as a complication of COVID-19. This observational retrospective study aims to further investigate the potential pathophysiology through assessing the pattern of microhaemorrhage and clinical characteristics of patients with COVID-19 and microhaemorrhage. By comparing to similar patterns of microhaemorrhage in other non-COVID-19 disease this study aims to propose possible common pathogenic mechanisms. MethodsA retrospective observational case series was performed identifying all patients with COVID-19 complicated by cerebral microhaemorrhage on MRI. The distribution and number of microhaemorrhages were recorded using the microbleed anatomical scale (MARS) and patients baseline characteristics and salient test results were also recorded. ResultsCerebral microhaemorrhages were noted to have a predilection for the corpus callosum, the juxtacortical white matter and brainstem. All patients had a preceding period of critical illness with respiratory failure and severe hypoxia necessitating intubation and mechanical ventilation. DiscussionThis study demonstrates a pattern of cerebral microhaemorrhage which is similar to the pattern reported in patients with non-COVID-19 related critical illness and other causes of severe hypoxia. This raises questions regarding whether microhaemorrhage occurs from endothelial dysfunction due the direct effect of SARS-CoV-2 infection or from the secondary effects of critical illness and hypoxia.
AU  - Dixon,L
DO  - 10.1136/svn-2020-000652
EP  - 322
PY  - 2020///
SN  - 2059-8696
SP  - 315
TI  - Cerebral microhaemorrhage in COVID-19:  A critical illness related phenomenon?
T2  - Stroke and Vascular Neurology
UR  - http://dx.doi.org/10.1136/svn-2020-000652
UR  - https://svn.bmj.com/content/5/4/315
UR  - http://hdl.handle.net/10044/1/83602
VL  - 5
ER  -
Download