Imperial College London
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Professor Mark Wilson

Faculty of Medicine, Department of Surgery & Cancer

Professor of Practice
 
 
 
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Contact

 

+44 (0)20 7594 1532m.wilson

 
 
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Location

 

Cambridge WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sagoo:2016:10.1177/0271678X15625350,
author = {Sagoo, RS and Hutchinson, CE and Wright, A and Handford, C and Parsons, H and Sherwood, V and Wayte, S and Nagaraja, S and Ng, Andwe E and Wilson, MH and others},
doi = {10.1177/0271678X15625350},
journal = {Journal of Cerebral Blood Flow & Metabolism},
pages = {319--331},
title = {Magnetic Resonance investigation into the mechanisms involved in the development of high-altitude cerebral edema},
url = {http://dx.doi.org/10.1177/0271678X15625350},
volume = {37},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Rapid ascent to high altitude commonly results in acute mountain sickness, and on occasion potentially fatal high-altitudecerebral edema. The exact pathophysiological mechanisms behind these syndromes remain to be determined. We report astudy in which 12 subjects were exposed to a FiO2¼ 0.12 for 22 h and underwent serial magnetic resonance imaging sequencesto enable measurement of middle cerebral artery velocity, flow and diameter, and brain parenchymal, cerebrospinal fluid andcerebral venous volumes. Ten subjects completed 22 h and most developed symptoms of acute mountain sickness (mean LakeLouise Score 5.4; p< 0.001 vs. baseline). Cerebral oxygen delivery was maintained by an increase in middle cerebral arteryvelocity and diameter (first 6 h). There appeared to be venocompression at the level of the small, deep cerebral veins (116 cm3at 2 h to 97 cm3 at 22 h; p< 0.05). Brain white matter volume increased over the 22-h period (574 ml to 587 ml; p < 0.001) andcorrelated with cumulative Lake Louise scores at 22 h (p< 0.05).We conclude that cerebral oxygen delivery was maintained byincreased arterial inflow and this preceded the development of cerebral edema. Venous outflow restriction appeared to play acontributory role in the formation of cerebral edema, a novel feature that has not been observed previously
AU  - Sagoo,RS
AU  - Hutchinson,CE
AU  - Wright,A
AU  - Handford,C
AU  - Parsons,H
AU  - Sherwood,V
AU  - Wayte,S
AU  - Nagaraja,S
AU  - Ng,Andwe E
AU  - Wilson,MH
AU  - others
DO  - 10.1177/0271678X15625350
EP  - 331
PY  - 2016///
SN  - 0271-678X
SP  - 319
TI  - Magnetic Resonance investigation into the mechanisms involved in the development of high-altitude cerebral edema
T2  - Journal of Cerebral Blood Flow & Metabolism
UR  - http://dx.doi.org/10.1177/0271678X15625350
UR  - http://hdl.handle.net/10044/1/37554
VL  - 37
ER  -
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