Imperial College London

Professor SirMagdiYacoub

Faculty of MedicineNational Heart & Lung Institute

Emeritus Professor
 
 
 
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Contact

 

+44 (0)1895 828 893m.yacoub

 
 
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Location

 

Heart Science Centre, HarefieldHarefield HospitalHarefield Hospital

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Summary

 

Publications

Publication Type
Year
to

1514 results found

Al-Shafai KN, Al-Hashemi M, Manickam C, Musa R, Selvaraj S, Syed N, Vempalli F, Ali M, Yacoub M, Estivill Xet al., 2021, Genetic evaluation of cardiomyopathies in Qatar identifies enrichment of pathogenic sarcomere gene variants and possible founder disease mutations in the Arabs, MOLECULAR GENETICS & GENOMIC MEDICINE, ISSN: 2324-9269

Journal article

Yacoub MH, Afifi A, Hosny H, Nagy M, Shehata N, Gamrah MA, El Sawy A, Simry W, Mahgoub A, Francis N, El Nashar H, Tseng Y-T, Romeih S, Aguib Het al., 2020, A New Technique for Shaping the Aortic Sinuses and Conserving Dynamism in the Remodeling Operation., Ann Thorac Surg

BACKGROUND: Preserving dynamism and recreating the sinuses in the Dacron graft are thought to be important for optimizing results of aortic valve-conserving operations. METHODS: We describe a novel technique that preserves dynamism and recreates the sinotubular junction. In addition, it tailors 3 sinuses of defined longitudinal and transverse curvatures in a straight Dacron tube during the operation. The technique has been used in 6 patients with varied aortic root pathology. We performed preoperative and postoperative multimodality imaging using computerized image analysis as well as 3-dimensional models. RESULTS: There was no early or midterm death. Upon discharge, patients were clinically well, with echocardiographic evidence of minimal (3 patients) or mild (3 patients) aortic regurgitation. Computed tomography and cardiac magnetic resonance imaging with extensive image analysis of the aortic root size, shape, and function showed partial or complete normalization of these parameters. This included the shape and dynamism of the aortic annulus and the size and shape of the geometric (effective) orifice. The 4-dimensional magnetic resonance imaging pattern of flow in the sinuses and ascending aorta showed favorable vortices in the sinuses, right-handed helical flow, and marked diminution of energy loss in the ascending aorta. CONCLUSIONS: The novel technique described here is simple, practical, and cost-effective because it uses a widely available straight Dacron tube. The technique does not use rigid internal or external support. The early results are encouraging. Larger series with longer follow-up are required.

Journal article

Badran HM, Faheem N, Zidan A, Yacoub MH, Soltan Get al., 2020, Effect of Short-Term L-Thyroxine Therapy on Left Ventricular Mechanics in Idiopathic Dilated Cardiomyopathy, JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, Vol: 33, Pages: 1234-1244, ISSN: 0894-7317

Journal article

Al Kindi HN, Shehata M, Ibrahim AM, Roshdy M, Simry W, Aguib Y, Yacoub MHet al., 2020, Cor Triatriatum Sinister (Divided Left Atrium): Histopathologic Features and Clinical Management, ANNALS OF THORACIC SURGERY, Vol: 110, Pages: 1380-1386, ISSN: 0003-4975

Journal article

Allouba M, Aguib Y, Walsh R, Afify A, Theotokis P, Galal A, Halawa S, Shorbagy S, Ibrahim AM, Kassem HS, Ellithy A, Buchan R, Hosny M, Whiffin N, Elguindy A, Anwer S, Cook SA, Ware JS, Barton PJ, Yacoub Met al., 2020, Analysis of HCM in an understudied population reveals a new mechanism of pathogenicity, Publisher: Cold Spring Harbor Laboratory

Hypertrophic Cardiomyopathy (HCM) is an inherited disease characterized by genetic and phenotypic heterogeneity. MYH7 represents one of the main sarcomere-encoding genes associated with HCM. Missense variants in this gene cause HCM through gain-of-function actions, whereby variants produce an abnormal activated protein which incorporates into the sarcomere as a "poison peptide". Here we report a frameshift variant in MYH7, c.5769delG, that is associated with HCM in an Egyptian cohort (3.3%) compared with ethnically-matched controls. This variant is absent from previously published large-scale Caucasian HCM cohorts. We further demonstrate strong evidence of co-segregation of c.5769delG with HCM in a large family (LOD score: 3.01). The predicted sequence of the variant MYH7 transcript shows that the frameshift results in a premature termination codon (PTC) downstream of the last exon-exon junction of the gene that is expected to escape nonsense-mediated decay (NMD). RNA sequencing of myocardial tissue obtained from a patient with the variant during surgical myectomy confirmed the expression of the variant MYH7 transcript. Our analysis reveals a new mechanism of pathogenicity in the understudied Egyptian population whereby distal PTC in MYH7 may lead to the expression of an abnormal protein.

Working paper

Mazzarotto F, Hawley M, Beltrami M, Beekman L, Boschi B, Girolami F, Roberts A, Lodder E, Cerbai E, Cook S, Ware J, Funke B, Olivotto I, Bezzina C, Barton PJR, Walsh Ret al., 2020, The genetic architecture of left ventricular non-compaction reveals both substantial overlap with other cardiomyopathies and a distinct aetiology in a subset of cases, Publisher: bioRxiv

Rationale: Left ventricular non-compaction (LVNC) is a condition characterised by trabeculations in the myocardial wall and is the subject of considerable conjecture as to whether it represents a distinct pathology or a secondary phenotype associated with other cardiac diseases, particularly cardiomyopathies. Objective: To investigate the genetic architecture of LVNC by identifying genes and variant classes robustly associated with disease and comparing these to other genetically characterised cardiomyopathies. Methods and Results: We performed rare variant association analysis using six different LVNC cohorts comprising 840 cases together with 125,748 gnomAD population controls and compared results to similar analyses with dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM) cases. We observed substantial overlap in genes and variant classes enriched in LVNC and DCM/HCM, indicating that in many cases LVNC belongs to a spectrum of more established cardiomyopathies, with non-compaction representing a phenotypic variation in patients with DCM- or HCM-causing variants. In contrast, five variant classes were uniquely enriched in LVNC cases, of which truncating variants in MYH7, ACTN2 and PRDM16 may represent a distinct LVNC aetiology. MYH7 truncating variants are generally considered as non-pathogenic but were detected in 2% of LVNC cases compared to 0.1% of controls, including a cluster of variants around a single splice region. Additionally, structural variants (exon deletions) in RYR2 and missense variants in the transmembrane region of HCN4 were enriched in LVNC cases, confirming prior reports regarding the association of these variant classes with combined LVNC and arrhythmia phenotypes. Conclusions: We demonstrated that genetic association analysis can clarify the relationship between LVNC and established cardiomyopathies, highlighted substantial overlap with DCM/HCM but also identified variant classes associated with distinct LVNC and with joint LVN

Working paper

Kalman JM, Lavandero S, Mahfoud F, Nahrendorf M, Yacoub MH, Zhao Det al., 2019, Looking back and thinking forwards-15 years of cardiology and cardiovascular research, NATURE REVIEWS CARDIOLOGY, Vol: 16, Pages: 651-660, ISSN: 1759-5002

Journal article

Al Kindi HN, Yacoub MH, 2019, Transection and Relocation of Anomalous Left Coronary Artery After Aborted Sudden Cardiac Death, ANNALS OF THORACIC SURGERY, Vol: 108, Pages: E25-E28, ISSN: 0003-4975

Journal article

Cavigli L, Fumagalli C, Maurizi N, Rossi A, Arretini A, Targetti M, Passantino S, Girolami F, Tomberli B, Baldini K, Tomberli A, Antoniucci D, Yacoub MH, Marchionni N, Stefano PL, Cecchi F, Olivotto Iet al., 2018, Timing of invasive septal reduction therapies and outcome of patients with obstructive hypertrophic cardiomyopathy, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 273, Pages: 155-161, ISSN: 0167-5273

Journal article

Mazine A, El-Hamamsy I, Verma S, Peterson MD, Bonow RO, Yacoub MH, David TE, Bhatt DLet al., 2018, Ross Procedure in Adults for Cardiologists and Cardiac Surgeons JACC State-of-the-Art Review, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 72, Pages: 2761-2777, ISSN: 0735-1097

Journal article

Zilla P, Yacoub M, Zuhlke L, Beyersdorf F, Sliwa K, Khubulava G, Bouzid A, Mocumbi AO, Velayoudam D, Shetty D, Ofoegbu C, Geldenhuys A, Brink J, Scherman J, du Toit H, Hosseini S, Zhang H, Luo X-J, Wang W, Mejia J, Kofidis T, Higgins RSD, Pomar J, Bolman RM, Mayosi BM, Madansein R, Bavaria J, Yanes-Quintana AA, Kumar AS, Adeoye O, Chauke RF, Williams DFet al., 2018, Global Unmet Needs in Cardiac Surgery, GLOBAL HEART, Vol: 13, Pages: 293-303, ISSN: 2211-8160

Journal article

Zilla P, Bolman RM, Yacoub MH, Beyersdorf F, Sliwa K, Zuhlke L, Higgins RSD, Mayosi B, Carpentier A, Williams Det al., 2018, The Cape Town Declaration on access to cardiac surgery in the developing world, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol: 156, Pages: 2206-2209, ISSN: 0022-5223

Journal article

Yacoub MH, McLeod C, 2018, The expanding role of implantable devices to monitor heart failure and pulmonary hypertension, NATURE REVIEWS CARDIOLOGY, Vol: 15, Pages: 770-779, ISSN: 1759-5002

Journal article

Yu JK, Sarathchandra P, Chester A, Yacoub M, Brand T, Butcher JTet al., 2018, Cardiac regeneration following cryoinjury in the adult zebrafish targets a maturation-specific biomechanical remodeling program, Scientific Reports, Vol: 8, ISSN: 2045-2322

Cardiac regeneration post-injury is a tantalizing feature of many lower vertebrates such as fishes and urodeles, but absent in adult humans. Restoration of pumping function is a key endpoint of cardiac regeneration, but very little is known about the biomechanical remodeling process. Here, we quantify and compare the evolution of cellular composition and mechanical stiffness of the zebrafish ventricular myocardium during maturation and following cryoinjury during regeneration to better understand the dynamics of biomechanical remodeling during these two processes. With increasing age, normal myocardial trabecular density and cardiomyocyte fraction increased, while non-myocyte cell fractions decreased. Cell density remained constant during maturation. Cardiomyocyte sarcomeres shortened to a minimum reached at 7.5 months of age, but lengthened with additional age. Concomitantly, ventricular wall stiffness increased up until 7.5 months before plateauing with additional age. Endothelial, myofibroblast/smooth muscle, and cardiomyocyte cell fractions were disrupted following cryoinjury, but were progressively restored to age-specific natural norms by 35 days post infarct (DPI). Infarcted myocardium stiffened immediately following cryoinjury and was a 100-fold greater than non-infarcted tissue by 3 DPI. By 14 DPI, stiffness of the infarcted myocardium had fallen below that of 0 DPI and had completely normalized by 35 DPI. Interestingly, cardiomyocyte sarcomere length increased until 14 DPI, but subsequently shortened to lengths below age-specific natural norms, indicating recovery from a volume overloaded condition. These observations are consistent with the view that regenerating myocardium requires biomechanical stimulation (e.g. strain) to rescue from a volume overloaded condition. Intriguingly, the biomechanical progression of the infarcted adult myocardial wall mirrors that of normal remodeling during aging. The biomechanical progression of the infarcted myocardium ta

Journal article

Watkins DA, Beaton AZ, Carapetis JR, Karthikeyan G, Mayosi BM, Wyber R, Yacoub MH, Zuhlke LJet al., 2018, Rheumatic Heart Disease Worldwide JACC Scientific Expert Panel, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 72, Pages: 1397-1416, ISSN: 0735-1097

Journal article

Zilla P, Bolman RM, Yacoub MH, Beyersdorf F, Sliwa K, Z├╝hlke L, Higgins RS, Mayosi B, Carpentier A, Williams Det al., 2018, The Cape Town Declaration on Access to Cardiac Surgery in the Developing World., Asian Cardiovasc Thorac Ann, Vol: 26, Pages: 535-539

Journal article

Zilla P, Bolman RM, Yacoub MH, Beyersdorf F, Sliwa K, Zuhlke L, Higgins RSD, Mayosi B, Carpentier A, Williams Det al., 2018, The Cape Town Declaration on Access to Cardiac Surgery in the Developing World, ANNALS OF THORACIC SURGERY, Vol: 106, Pages: 930-933, ISSN: 0003-4975

Journal article

Kaniewska-Bednarczuk E, Kutryb-Zajac B, Sarathchandra P, Pelikant-Malecka I, Sielicka A, Piotrowska I, Slominska EM, Chester AH, Yacoub MH, Smolenski RTet al., 2018, CD39 and CD73 in the aortic valve-biochemical and immunohistochemical analysis in valve cell populations and its changes in valve mineralization, CARDIOVASCULAR PATHOLOGY, Vol: 36, Pages: 53-63, ISSN: 1054-8807

Journal article

Yacoub MH, Aguib H, Abou Gamrah M, Shehata N, Nagy M, Donia M, Aguib Y, Saad H, Romeih S, Torii R, Afifi A, Lee S-Let al., 2018, Aortic root dynamism, geometry, and function after the remodeling operation: Clinical relevance, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol: 156, Pages: 951-+, ISSN: 0022-5223

Journal article

Zilla P, Bolman RM, Yacoub MH, Beyersdorf F, Sliwa K, Zuhlke L, Higgins RSD, Mayosi B, Carpentier A, Williams Det al., 2018, The Cape Town declaration on access to cardiac surgery in the developing world, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 54, Pages: 407-410, ISSN: 1010-7940

Journal article

Zilla P, Bolman RM, Yacoub MH, Beyersdorf F, Sliwa K, Zuhlke L, Higgins RSD, Mayosi B, Carpentier A, Williams Det al., 2018, The Cape Town Declaration on Access to Cardiac Surgery in the Developing World, SAMJ SOUTH AFRICAN MEDICAL JOURNAL, Vol: 108, Pages: 702-704, ISSN: 0256-9574

Journal article

Rich S, Haworth SG, Hassoun PM, Yacoub MHet al., 2018, Pulmonary hypertension: the unaddressed global health burden, LANCET RESPIRATORY MEDICINE, Vol: 6, Pages: 577-579, ISSN: 2213-2600

Journal article

Zilla P, Bolman RM, Yacoub MH, Beyersdorf F, Sliwa K, Zuhlke L, Higgins RSD, Mayosi B, Carpentier A, Williams Det al., 2018, The Cape Town Declaration on Access to Cardiac Surgery in the Developing World, CARDIOVASCULAR JOURNAL OF AFRICA, Vol: 29, Pages: 256-259, ISSN: 1995-1892

Journal article

Mongkoldhumrongkul N, Latif N, Yacoub MH, Chester AHet al., 2018, Effect of side-specific valvular shear stress on the content of extracellular matrix in aortic valves, Cardiovascular Engineering and Technology, Vol: 9, Pages: 151-157, ISSN: 1869-4098

Responses of valve endothelial cells (VECs) to shear stresses are important for the regulation of valve durability. However, the effect of flow patterns subjected to VECs on the opposite surfaces of the valves on the production of extracellular matrix (ECM) has not yet been investigated. This study aims to investigate the response of side-specific flow patterns, in terms of ECM synthesis and/or degradation in porcine aortic valves. Aortic and ventricular sides of aortic valve leaflets were exposed to oscillatory and laminar flow generated by a Cone-and-Plate machine for 48 h. The amount of collagen, GAGs and elastin was quantified and compared to samples collected from the same leaflets without exposing to flow. The results demonstrated that flow is important to maintain the amount of GAGs and elastin in the valve, as compared to the effect of static conditions. Particularly, the laminar waveform plays a crucial role on the modulation of elastin in side-independent manner. Furthermore, the ability of oscillatory flow on the aortic surface to increase the amount of collagen and GAGs cannot be replicated by exposure of an identical flow pattern on the ventricular side of the valve. Side-specific responses to the particular patterns of flow are important to the regulation of ECM components. Such understanding is imperative to the creation of tissue-engineered heart valves that must be created from the “appropriate” cells that can replicate the functions of the native VECs to regulate the different constituents of ECM.

Journal article

Yacoub MH, Hosny H, Romeih S, Aguib H, Simry W, Afifi A, Sedky Yet al., 2018, MID-TERM OUTCOME OF A MODIFIED MUSTARD OPERATION FOR NEGLECTED TRANSPOSITION OF THE GREAT ARTERIES, 67th Annual Scientific Session and Expo of the American-College-of-Cardiology (ACC), Publisher: ELSEVIER SCIENCE INC, Pages: 591-591, ISSN: 0735-1097

Conference paper

Haikal RR, Hua C, Perry JJ, O'Nolan D, Syed I, Kumar A, Chester AH, Zaworotko MJ, Yacoub MH, Alkordi MHet al., 2017, Controlling the Uptake and Regulating the Release of Nitric Oxide in Microporous Solids, ACS APPLIED MATERIALS & INTERFACES, Vol: 9, Pages: 43520-43528, ISSN: 1944-8244

Journal article

You AYF, Bergholt MS, St-Pierre JP, Chester AH, Yacoub MH, Bertazzo S, Stevens MMet al., 2017, Raman spectroscopy imaging reveals interplay between atherosclerosis and medial calcification in human aorta, Science Advances, Vol: 3, ISSN: 2375-2548

Medial calcification in the human aorta accumulates during aging and is known to be aggravated in several diseases. Atherosclerosis, another major cause of cardiovascular calcification, shares some common aggravators. However, the mechanisms of cardiovascular calcification remain poorly understood. To elucidate the relationship between medial aortic calcification and atherosclerosis, we characterized the cross-sectional distributions of the predominant minerals in aortic tissue, apatite and whitlockite, and the associated extracellular matrix. We also compared the cellular changes between atherosclerotic and nonatherosclerotic human aortic tissues. This was achieved through the development of Raman spectroscopy imaging methods that adapted algorithms to distinguish between the major biomolecules present within these tissues. We present a relationship between apatite, cholesterol, and triglyceride in atherosclerosis, with the relative amount of all molecules concurrently increased in the atherosclerotic plaque. Further, the increase in apatite was disproportionately large in relation to whitlockite in the aortic media directly underlying a plaque, indicating that apatite is more pathologically significant in atherosclerosis-aggravated medial calcification. We also discovered a reduction of β-carotene in the whole aortic intima, including a plaque in atherosclerotic aortic tissues compared to nonatherosclerotic tissues. This unprecedented biomolecular characterization of the aortic tissue furthers our understanding of pathological and physiological cardiovascular calcification events in humans.

Journal article

Kotit S, Said K, ElFaramawy A, Mahmoud H, Phillips DIW, Yacoub MHet al., 2017, Prevalence and prognostic value of echocardiographic screening for rheumatic heart disease, OPEN HEART, Vol: 4, ISSN: 2053-3624

Journal article

Yacoub MH, Bonow RO, 2017, Editors' page., Glob Cardiol Sci Pract, Vol: 2017, Pages: e201716-e201716, ISSN: 2305-7823

Journal article

Krishnamoorthy N, Tseng Y-T, Gajendrarao P, Sarathchandra P, McCormack A, Carubelli I, Sohier J, Latif N, Chester AH, Yacoub MHet al., 2017, A Strategy to Enhance Secretion of Extracellular Matrix Components by Stem Cells: Relevance to Tissue Engineering., Tissue Engineering: Parts A, B, and C, Vol: 24, Pages: 145-156, ISSN: 1937-3341

The ability of cells to secrete extracellular matrix proteins is an important property in the repair, replacement, and regeneration of living tissue. Cells that populate tissue-engineered constructs need to be able to emulate these functions. The motifs, KTTKS or palmitoyl-KTTKS (peptide amphiphile), have been shown to stimulate production of collagen and fibronectin in differentiated cells. Molecular modeling was used to design different forms of active peptide motifs to enhance the efficacy of peptides to increase collagen and fibronectin production using terminals KTTKS/SKTTK/SKTTKS connected by various hydrophobic linkers, V4A3/V4A2/A4G3. Molecular dynamic simulations showed SKTTKS-V4A3-SKTTKS (P3), with palindromic (SKTTKS) motifs and SKTTK-V4A2-KTTKS (P5), maintained structural integrity and favorable surface electrostatic distributions that are required for functionality. In vitro studies showed that peptides, P3 and P5, showed low toxicity to human adipose-derived stem cells (hADSCs) and significantly increased the production of collagen and fibronectin in a concentration-dependent manner compared with the original active peptide motif. The 4-day treatment showed that stem cell markers of hADSCs remained stable with P3. The molecular design of novel peptides is a promising strategy for the development of intelligent biomaterials to guide stem cell function for tissue engineering applications.

Journal article

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