Publications
2089 results found
MANKAD PS, YACOUB MH, 1993, SYSTOLIC AND DIASTOLIC FUNCTION OF BOTH VENTRICLES AFTER PROLONGED CARDIOPLEGIC ARREST, ANNALS OF THORACIC SURGERY, Vol: 55, Pages: 933-939, ISSN: 0003-4975
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- Citations: 5
BELVISI MG, WARD JK, TADJKARIMI S, et al., 1993, INHIBITORY NANC NERVES IN HUMAN AIRWAYS - DIFFERENCES IN DISEASE AND AFTER EXTRINSIC DENERVATION, AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 147, Pages: A286-A286, ISSN: 0003-0805
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- Citations: 13
FITZPATRICK AP, BANNER N, CHENG A, et al., 1993, VASOVAGAL REACTIONS MAY OCCUR AFTER ORTHOTOPIC HEART-TRANSPLANTATION, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 21, Pages: 1132-1137, ISSN: 0735-1097
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- Citations: 188
BELVISI MG, WARD JK, PATEL HJ, et al., 1993, MU-OPIOIDS INHIBIT ELECTRICALLY EVOKED ACETYLCHOLINE-RELEASE IN HUMAN AND GUINEA-PIG TRACHEA, AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 147, Pages: A502-A502, ISSN: 0003-0805
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- Citations: 5
SIMON J, GIBBS R, PURCELL H, et al., 1993, DIURNAL-VARIATION IN PRIMARY PULMONARY-HYPERTENSION - AMBULATORY MEASUREMENT OF PULMONARY-ARTERY PRESSURE IN PATIENTS AWAITING LUNG TRANSPLANTATION, AMERICAN REVIEW OF RESPIRATORY DISEASE, Vol: 147, Pages: A537-A537, ISSN: 0003-0805
BARTON PJR, BHAVSAR P, BRAND NJ, et al., 1993, TROPONIN GENE-EXPRESSION IN THE DEVELOPING HUMAN HEART, JOURNAL OF CELLULAR BIOCHEMISTRY, Pages: 227-227, ISSN: 0730-2312
CHANTHOMAS PS, THOMPSON RP, ROBERT B, et al., 1993, EXPRESSION OF HOMEOBOX GENES MSX-1 (HOX-7) AND MSX-2 (HOX-8) DURING CARDIAC DEVELOPMENT IN THE CHICK, JOURNAL OF CELLULAR BIOCHEMISTRY, Pages: 209-209, ISSN: 0730-2312
MIURA M, BELVISI MG, WARD JK, et al., 1993, BRONCHODILATING EFFECTS OF THE NOVEL POTASSIUM CHANNEL OPENER HOE-234 IN HUMAN AIRWAYS INVITRO, BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Vol: 35, Pages: 318-320, ISSN: 0306-5251
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- Citations: 10
LYTHALL DA, BISHOP J, GREENBAUM RA, et al., 1993, RELATIONSHIP BETWEEN MYOCARDIAL COLLAGEN AND ECHO AMPLITUDE IN NON-FIBROTIC HEARTS, EUROPEAN HEART JOURNAL, Vol: 14, Pages: 344-350, ISSN: 0195-668X
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- Citations: 41
Sarsam MA, Yacoub M, 1993, Remodeling of the aortic valve anulus., J Thorac Cardiovasc Surg, Vol: 105, Pages: 435-438, ISSN: 0022-5223
Isolated aortic valve regurgitation that results from disease that primarily affects the aortic wall can be repaired by remodeling of the aortic anulus to restore its normal geometry. This involves excision of the aortic wall to within 2 to 3 mm of the leaflet attachments, detachment of the coronary ostia, reshaping of the anulus with the aid of a Dacron graft, and then reimplantation of the coronary arteries. Increases in the surface area of the leaflet that are caused by root dilatation are often present and can be accommodated in the repair procedure. In this study we describe our experience with 10 patients with annuloaortic ectasia who underwent the remodeling procedure at the National Heart Hospital and the Royal Brompton Hospital from 1982 to 1990.
ALLEN SP, DASHWOOD MR, CHESTER AH, et al., 1993, INFLUENCE OF ATHEROSCLEROSIS ON THE VASCULAR REACTIVITY OF ISOLATED HUMAN EPICARDIAL CORONARY-ARTERIES TO LEUKOTRIENE-C(4), CARDIOSCIENCE, Vol: 4, Pages: 47-54, ISSN: 1015-5007
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- Citations: 30
CHESTER AH, ALLEN SP, TADJKARIMI S, et al., 1993, INTERACTION BETWEEN THROMBOXANE-A2 AND 5-HYDROXYTRYPTAMINE RECEPTOR SUBTYPES IN HUMAN CORONARY-ARTERIES, CIRCULATION, Vol: 87, Pages: 874-880, ISSN: 0009-7322
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- Citations: 64
LUU TN, CHESTER AH, ONEIL GS, et al., 1993, DIFFERENT RESPONSES OF THE HUMAN GASTROEPIPLOIC AND INTERNAL MAMMARY ARTERIES TO VASOACTIVE PEPTIDES, AMERICAN JOURNAL OF PHYSIOLOGY, Vol: 264, Pages: H583-H587, ISSN: 0002-9513
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- Citations: 15
Hunt BJ, Segal H, Yacoub M, 1993, Hemostatic changes in heart transplant recipients and their relationship to accelerated coronary sclerosis., Transplantation, Vol: 55, Pages: 309-315, ISSN: 0041-1337
Hemostasis was assessed in 115 steady-state heart transplant recipients (HTRs) and compared with that of 23 age-matched healthy controls and 21 age-matched patients with ischemic heart disease (IHD). Compared with the controls, the HTRs had increased levels of fibrinogen (mean and 95% confidence limits of 4.50 [4.32-4.68] g/L versus 3.47 [3.07-3.87] g/L, P < 0.001), factor VIIC (1.16 [0.98-1.21] IU/ml versus 0.99 [0.89-1.10] IU/ml, P < 0.001), and von Willebrand factor antigen (1.72 [1.58-1.88] IU/ml versus 1.00 [0.80-1.26] IU/ml, P < 0.001). HTRs had increased antithrombin III activity (P = 0.002) and protein C activity (P = 0.002), with a decrease in total protein S levels (P < 0.001) but no change in free protein S levels. Stepwise discriminant analysis of hemostatic variables showed that fibrinogen was the best discriminator of the three groups, classifying 55.6% of HTR, 40% of IHD, and 66.7% of the controls. More marked prothrombotic changes were found in HTRs transplanted for IHD than for other causes; this reached significance for prothrombin (P = 0.048), factor IX (P = 0.003), and poor fibrinolytic activity as measured by euglobulin clot lysis time (P = 0.008). The HTRs with accelerated coronary sclerosis (ACS) tended to have the most prothrombotic changes; this reached significance with factor IX (P = 0.03). In conclusion, HTRs have perturbed hemostasis; the net effects of these changes are prothrombotic. The relationship between prothrombotic changes and ACS merits further studies.
BHAVSAR PK, BRAND NJ, YACOUB MH, et al., 1993, THE HUMAN CARDIAC TROPONIN-I GENE - A MODEL FOR CARDIAC-SPECIFIC REGULATION, JOURNAL OF CELLULAR BIOCHEMISTRY, Pages: 189-189, ISSN: 0730-2312
MULCAHY D, FITZGERALD M, WRIGHT C, et al., 1993, LONG-TERM FOLLOW-UP OF SEVERELY ILL PATIENTS WHO UNDERWENT URGENT CARDIAC TRANSPLANTATION, BRITISH MEDICAL JOURNAL, Vol: 306, Pages: 98-101, ISSN: 0959-8138
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- Citations: 11
BRAND NJ, DABHADE N, BHAVSAR PK, et al., 1993, IDENTIFICATION OF ZINC FINGER AND SRY-LIKE TRANSCRIPTION FACTORS EXPRESSED IN HUMAN HEART, JOURNAL OF CELLULAR BIOCHEMISTRY, Pages: 190-190, ISSN: 0730-2312
Smolenski RT, Suitters A, Yacoub MH, 1993, Erratum: Adenine nucleotide catabolism and adenosine formation in isolated human cardiomyocytes (Journal of Molecular and Cellular Cardiology, 1992, 24: 91-96), Journal of Molecular and Cellular Cardiology, Vol: 25, ISSN: 0022-2828
Luu TN, Chester AH, O'Neil GS, et al., 1993, Different responses of the human gastroepiploic and internal mammary arteries to vasoactive peptides, American Journal of Physiology - Heart and Circulatory Physiology, Vol: 264, ISSN: 0002-9513
Peptidergic influences have been implicated in the control of tone in human arteries. We have examined the response of human gastroepiploic arteries (GEA) and internal mammary arteries (IMA) to three vasoactive peptides in vitro. Vasoactive intestinal peptide (VIP, 10-11 to 3 x 10-7 M) elicited relaxations in the GEA and IMA [maximum generated response (E(max)) 74.6 ± 9.4 and 56.5 ± 7.7%, respectively] that were significantly reduced after removal of endothelium. N(G)-monomethyl-L-arginine (L-NMMA) and indomethacin partially inhibited the response of the GEA to VIP (P < 0.05). In the IMA, VIP-induced relaxation was significantly attenuated by L-NMMA but not indomethacin. Bombesin (10-10 to 3 x 10-6 M) produced endothelium- dependent relaxation selectively in the GEA, which was only inhibited by indomethacin (E(max) reduced from 59.0 ± 10.0 to 12.8 ± 4.9%, P < 0.001). Bombesin elicited a weak endothelium-independent constriction in the IMA, giving 12.7 ± 1.2% of the response to 90 mM KCl. Gastrin (10-10 to 3 x 10-7 M) had no effect on IMA segments but induced a relaxation of 40.0 ± 3.2% in the GEA via a direct action on the smooth muscle. It is concluded that human GEA and IMA exhibit heterogenous responses to VIP, bombesin, and gastrin that may have important physiological and clinical implications.
Smolenski RT, Suitters A, Yacoub MH, 1993, Erratum: Adenine nucleotide catabolism and adenosine formation in isolated human cardiomyocytes (Journal of Molecular and Cellular Cardiology (1992) 24: (91-96)), Journal of Molecular and Cellular Cardiology, Vol: 25, ISSN: 0022-2828
SMOLENSKI RT, DEJONG JW, JANSSEN M, et al., 1993, FORMATION AND BREAKDOWN OF URIDINE IN ISCHEMIC HEARTS OF RATS AND HUMANS, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Vol: 25, Pages: 67-74, ISSN: 0022-2828
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- Citations: 32
Swan JW, Norell M, Yacoub M, et al., 1993, Coronary angioplasty in cardiac transplant recipients., Eur Heart J, Vol: 14, Pages: 65-70, ISSN: 0195-668X
Accelerated coronary artery disease following cardiac transplantation remains an important obstacle to long-term survival and the correct management strategy remains unclear. This observational, prospective study was designed to examine the feasibility of using percutaneous transluminal coronary angioplasty (PTCA) in the treatment of post-transplant coronary disease. Thirteen consecutive patients were selected from the total population of 276 transplant recipients who underwent routine coronary angiography between 1987 and 1990. Selection of patients was on angiographic criteria alone and PTCA was performed to all accessible stenoses with more than 80% luminal narrowing. PTCA was performed using standard angioplasty equipment and procedure as considered appropriate for the individual lesion. A successful PTCA was defined as more than 30% reduction in luminal narrowing and a residual narrowing of less than 50%. Restenosis was defined as a loss of 50% or more of the gain achieved at the time of successful PTCA or more than a 30% increase in narrowing at the site of stenosis. A total of 31 lesions were dilated in this group and a successful result was achieved in 29 of these (93%) and in 12 of the 13 patients. The one patient with failed PTCA underwent later successful coronary artery bypass grafting to complete revascularization. Four of the 13 patients have had two angioplasty procedures, two for restenosis and two for disease progression in other sites. One patient died 15 months after the initial PTCA and the remaining 12 were asymptomatic with good exercise tolerance and ventricular function at a mean of 19 months (range 1-39 months) following first PTCA.(ABSTRACT TRUNCATED AT 250 WORDS)
Dashwood MR, Barker SG, Muddle JR, et al., 1993, [125I]-endothelin-1 binding to vasa vasorum and regions of neovascularization in human and porcine blood vessels: a possible role for endothelin in intimal hyperplasia and atherosclerosis., J Cardiovasc Pharmacol, Vol: 22 Suppl 8, Pages: S343-S347, ISSN: 0160-2446
The distribution of [125I]-endothelin-1 (ET-1) binding sites on human and porcine vessels was studied with in vitro receptor autoradiography. Binding to normal human saphenous veins was compared to atheromatous veins used as coronary artery bypass grafts. Binding to porcine vessels, from an experimental model of intimal hyperplasia, was also studied. There was dense binding of [125I]-ET-1 to smooth muscle of all vessels examined, as well as to the vasa vasorum and regions of neovascularization of diseased vessels. Binding to microvasculature (vasa vasorum and regions of neovascularization) is of particular interest, because ET-1 has been shown to have mitogenic activity on vascular smooth-muscle cells in culture and microvessels are extremely sensitive to the constrictor effect of ET-1. Binding of [125I]-ET-1 to vasa vasorum of normal blood vessels and to regions of neovascularization of atheromatous vessels suggests that ET-1 plays a pathophysiologic role in atherosclerosis.
Taylor PM, Rose ML, Yacoub MH, 1993, Coronary artery immunogenicity: a comparison between explanted recipient or donor hearts and transplanted hearts., Transpl Immunol, Vol: 1, Pages: 294-301, ISSN: 0966-3274
Transplant associated accelerated coronary sclerosis (TX-ACS) is the most serious complication following heart transplantation. In order to elucidate the involvement of possible immune mechanisms, we have used immunocytochemistry to characterize the antigens present on the endothelium and the cells present within coronary arteries taken at time of surgery from patients who required retransplantation (n = 4) or at post mortem (n = 10) from transplant patients who died. Coronary arteries from unused donor hearts (n = 4) or heart transplant recipients whose original disease did not involve the coronaries (n = 8) were used as controls. Endothelium from all control coronary arteries strongly expressed MHC class I, DR antigen, PECAM, ICAM-1 and E-selectin. Expression of VCAM-1, DP and particularly DQ antigen was more patchy. There was no significant difference in the expression of MHC or adhesion molecules between control arteries and those from transplant patients. More cells were present in the intima and media of coronary arteries taken from transplanted hearts, particularly those with intimitis/TX-ACS, than were found in control coronaries. T cells were present in the intima of most coronaries, but the media of only the transplanted coronaries. Cells expressing prolyl 4-hydroxylase were more evident on coronaries from transplanted hearts. In conclusion, coronary arteries from hearts used for transplants appear to be highly immunogenic. This suggests the endothelium would need little, if any, stimuli to initiate as well as be a target for an immune response after transplantation.
Smith JD, Danskine AJ, Laylor RM, et al., 1993, The effect of panel reactive antibodies and the donor specific crossmatch on graft survival after heart and heart-lung transplantation., Transpl Immunol, Vol: 1, Pages: 60-65, ISSN: 0966-3274
Data from 699 cardiac and 290 heart-lung transplants has been analysed to determine the importance of the lymphocytotoxic crossmatch result and panel reactive antibody (PRA) status on graft survival. Donor reactive crossmatching was performed for 636 cardiac transplants. One year actuarial survival for a negative crossmatch (n = 580) was 73% compared to 56% for the positive crossmatch recipients (n = 56) p = 0.0014. Where crossmatches were performed on separated T and B cells, the T cell directed crossmatch was found to be highly predictive of graft failure in 289 cardiac transplants. One year survival for a negative crossmatch was 73% (n = 258), for B cell positive crossmatch recipients 62% (n = 24), and for a positive T cell crossmatch 28% (n = 7) (p = 0.001). Patients' PRA status were grouped into those with negative, medium and high frequencies. There was a trend (not statistically significant) for patients with PRA above 50% to have poor graft survival. Patients with PRA above 50% were significantly more likely to have a positive lymphocytotoxic crossmatch against donor lymphocytes. Donor reactive crossmatching was performed for 283 heart-lung transplants. One year actuarial survival for a negative crossmatch was 61% (n = 251) and for a positive result was 50% (n = 32), p = 0.02.(ABSTRACT TRUNCATED AT 250 WORDS)
DASHWOOD MR, BARKER SGE, MUDDLE JR, et al., 1993, [I-125] ENDOTHELIN-1 BINDING TO VASA VASORUM AND REGIONS OF NEOVASCULARIZATION IN HUMAN AND PORCINE BLOOD-VESSELS - A POSSIBLE ROLE FOR ENDOTHELIN IN INTIMAL HYPERPLASIA AND ATHEROSCLEROSIS, 3rd International Conference on Endothelin, Publisher: LIPPINCOTT-RAVEN PUBL, Pages: S343-S347, ISSN: 0160-2446
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- Citations: 53
SHEPHARD RJ, KAVANAGH T, YACOUB MH, 1993, RATINGS OF PERCEIVED EXERTION AFTER CARDIAC TRANSPLANTATION - THE EFFECT OF ENDURANCE TRAINING, Vth World Congress of Cardiac Rehabilitation, Publisher: INTERCEPT LTD, Pages: 299-303
KAVANAGH T, YACOUB MH, 1993, EFFECTS OF LONG-TERM ENDURANCE TRAINING AFTER CARDIAC TRANSPLANTATION, Vth World Congress of Cardiac Rehabilitation, Publisher: INTERCEPT LTD, Pages: 305-311
BARBIR M, KUSHWAHA S, HUNT B, et al., 1992, LIPOPROTEIN(A) AND ACCELERATED CORONARY-ARTERY DISEASE IN CARDIAC TRANSPLANT RECIPIENTS, LANCET, Vol: 340, Pages: 1500-1502, ISSN: 0140-6736
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- Citations: 77
BARBIR M, HUNT B, KUSHWAHA S, et al., 1992, MAXEPA VERSUS BEZAFIBRATE IN HYPERLIPIDEMIC CARDIAC TRANSPLANT RECIPIENTS, AMERICAN JOURNAL OF CARDIOLOGY, Vol: 70, Pages: 1596-1601, ISSN: 0002-9149
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- Citations: 23
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