24 results found
Wong KHF, Bosanquet DC, Ambler GK, et al., 2020, Correction to: The CLEAR (Considering Leading Experts' Antithrombotic Regimes around peripheral angioplasty) survey: an international perspective on antiplatelet and anticoagulant practice for peripheral arterial endovascular intervention., CVIR Endovasc, Vol: 3
An amendment to this paper has been published and can be accessed via the original article.
Elliott L, Coulman K, Blencowe NS, et al., 2020, A systematic review of reporting quality for anaesthetic interventions in randomised controlled trials, ANAESTHESIA, Vol: 76, Pages: 832-836, ISSN: 0003-2409
Theivacumar NS, Glasgow S, Najem M, et al., 2020, Pledget reinforcement and bidirectional compression as adjunctive techniques for suture-based closure of arterial cannulation sites in percutaneous endovascular aneurysm repair, ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND, Vol: 102, Pages: 636-637, ISSN: 0035-8843
Qureshi MI, Li HL, Ambler GK, et al., 2020, Antiplatelet and Anticoagulant Use in Randomised Trials of Patients Undergoing Endovascular Intervention for Peripheral Arterial Disease: Systematic Review and Narrative Synthesis, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 60, Pages: 77-87, ISSN: 1078-5884
Elliott L, Coulman K, Blencowe NS, et al., 2020, Protocol for a systematic review of reporting standards of anaesthetic interventions in randomised controlled trials, BMJ OPEN, Vol: 10, ISSN: 2044-6055
Wong KHF, Bosanquet DC, Ambler GK, et al., 2019, The CLEAR (Considering Leading Experts’ Antithrombotic Regimes around peripheral angioplasty) survey: an international perspective on antiplatelet and anticoagulant practice for peripheral arterial endovascular intervention, CVIR Endovascular, Vol: 2
Background: Antiplatelet and anticoagulant therapy are commonly used before, during and after peripheral arterial endovascular intervention. This survey aimed to establish antiplatelet and anticoagulant choice for peripheral arterial endovascular intervention in contemporary clinical practice. Methods: Pilot-tested questionnaire distributed via collaborative research networks. Results: One hundred and sixty-two complete responses were collected from responders in 22 countries, predominantly the UK (48%) and the rest of the European Union (44%). Antiplatelet monotherapy was the most common choice pre-procedurally (62%). In the UK, there was no difference between dual and single antiplatelet therapy use post procedure (50% vs. 37% p = 0.107). However, a significant majority of EU respondents used dual therapy (68% vs. 20% p < 0.001). There was variation in choice of antiplatelet therapy by the device used and the anatomical location of the intervention artery. The majority (82%) of respondents believed there was insufficient evidence to guide antithrombotic therapy after peripheral endovascular intervention and most (92%) would support a randomised trial. Conclusions: There is widespread variation in the use of antiplatelet therapy, especially post peripheral arterial endovascular intervention. Clinicians would support the development of a randomised trial comparing dual antiplatelet therapy with monotherapy.
Qureshi MI, Davies AH, 2018, Endovascular aneurysm repair in the elderly: First do no harm, VASCULAR, Vol: 26, Pages: 113-114, ISSN: 1708-5381
Qureshi MI, Greco M, Vorkas PA, et al., 2017, Application of metabolic profiling to abdominal aortic aneurysm research, Journal of Proteome Research, Vol: 16, Pages: 2325-2332, ISSN: 1535-3893
Abdominal aortic aneurysm (AAA) is a complex disease posing diagnostic and therapeutic challenges. Metabonomics may aid in the diagnosis of AAA, determination of individualized risk, discovery of therapeutic targets, and improve understanding of pathogenesis. A systematic review of the diversity and outcomes of existing AAA metabonomic research has been performed. Original research studies applying metabonomics to human aneurysmal disease are included. Seven relevant articles were identified: four studies were based on plasma/serum metabolite profiling, and three studies examined aneurysmal tissue. Aminomalonic acid, guanidinosuccinic acid, and glycerol emerge as potential plasma biomarkers of large aneurysm. Lipid profiling improves predictive models of aneurysm presence. Patterns of metabolite variation associated with AAA relate to carbohydrate and lipid metabolism. Perioperative perturbations in metabolites suggest differential systemic inflammatory responses to surgery, generating hypotheses for adjunctive perioperative therapy. Significant limitations include small study sizes, lack of correction for multiple testing false discovery rates, and single time-point sampling. Metabolic profiling carries the potential to identify biomarkers of AAA and elucidate pathways underlying aneurysmal disease. Statistically and methodologically robust studies are required for validation, addressing the hiatus in understanding mechanisms of aneurysm growth and developing effective treatment strategies.
Qureshi MI, Vosicka K, Lim CS, et al., 2017, Post thrombotic syndrome following deep vein thrombosis in paediatric patients, Phlebology, ISSN: 1433-3031
Qureshi MI, Vorkas PA, Coupland AP, et al., 2016, Lessons from metabonomics on the neurobiology of stroke, Neuroscientist, Vol: 23, Pages: 374-382, ISSN: 1073-8584
The application of metabonomic science to interrogate stroke permits the study of metabolite entities, small enough to cross the blood-brain barrier, that provide insight into neuronal dysfunction, and may serve as reservoirs of biomarker discovery. This systematic review examines the applicability of metabolic profiling in ischemic stroke research. Six human studies utilizing metabolic profiling to analyze biofluids from ischemic stroke patients have been included, employing 1H-NMR and/or mass spectrometry to analyze plasma, serum, and/or urine in a targeted or untargeted fashion. Three are diagnostic studies, and one investigates prognostic biomarkers of stroke recurrence following transient ischemic attack. Two studies focus on metabolic distinguishers of depression or cognitive impairment following stroke. Identified biomarkers from blood and urine predominantly relate to homocysteine and folate, branched chain amino acid, and lipid metabolism. Statistical models are well fitted and reproducible, with excellent validation outcomes, demonstrating the feasibility of metabolic profiling to study a complex disorder with multicausal pathology, such as stroke.
Lewis TL, Fothergill RT, Aneurysm-FILTR Study Group, et al., 2016, Ambulance smartphone tool for field triage of ruptured aortic aneurysms (FILTR): study protocol for a prospective observational validation of diagnostic accuracy, BMJ Open, Vol: 6, ISSN: 2044-6055
Introduction Rupture of an abdominal aortic aneurysm (rAAA) carries a considerable mortality rate and is often fatal. rAAA can be treated through open or endovascular surgical intervention and it is possible that more rapid access to definitive intervention might be a key aspect of improving mortality for rAAA. Diagnosis is not always straightforward with up to 42% of rAAA initially misdiagnosed, introducing potentially harmful delay. There is a need for an effective clinical decision support tool for accurate prehospital diagnosis and triage to enable transfer to an appropriate centre.Methods and analysis Prospective multicentre observational study assessing the diagnostic accuracy of a prehospital smartphone triage tool for detection of rAAA. The study will be conducted across London in conjunction with London Ambulance Service (LAS). A logistic score predicting the risk of rAAA by assessing ten key parameters was developed and retrospectively validated through logistic regression analysis of ambulance records and Hospital Episode Statistics data for 2200 patients from 2005 to 2010. The triage tool is integrated into a secure mobile app for major smartphone platforms. Key parameters collected from the app will be retrospectively matched with final hospital discharge diagnosis for each patient encounter. The primary outcome is to assess the sensitivity, specificity and positive predictive value of the rAAA triage tool logistic score in prospective use as a mob app for prehospital ambulance clinicians. Data collection started in November 2014 and the study will recruit a minimum of 1150 non-consecutive patients over a time period of 2 years.Ethics and dissemination Full ethical approval has been gained for this study. The results of this study will be disseminated in peer-reviewed publications, and international/national presentations.
Qureshi MI, Davies AH, 2016, Carotid intervention following transient ischaemic attack: what are we waiting for?, Vascular, ISSN: 1708-5381
Transient ischaemic attack secondary to carotid stenosis has the highest risk of stroke recurrence compared with other aetiological subtypes. International guidelines advocate carotid intervention within one to two weeks of the index neurological event. Traditionally, delayed carotid intervention was perceived to be a safer management strategy, yet classic trials of endarterectomy and recent meta-analysis of carotid intervention demonstrate the safety of hyperacute carotid intervention. Data from international studies suggest that targets are not being met, the reasons for which are multifactorial, but patients suffering transient or ocular symptoms are particularly delayed. Efforts should be made to conduct regional studies investigating the root causes of delayed intervention, with subsequent policy adjustment to expedite intervention, and interim optimisation of medical management to reduce the incidence of recurrent stroke.
Qureshi MI, Davies AH, 2016, Thromboprophylaxis following superficial venous intervention, PHLEBOLOGY, Vol: 31, Pages: 77-80, ISSN: 0268-3555
Chaturvedi S, Barrett K, Brott TG, 2016, TEMPORAL TRENDS IN SAFETY OF CAROTID ENDARTERECTOMY IN ASYMPTOMATIC PATIENTS: SYSTEMATIC REVIEW, NEUROLOGY, Vol: 86, Pages: 313-313, ISSN: 0028-3878
Munster AB, Franchini AJ, Qureshi MI, et al., 2016, TEMPORAL TRENDS IN SAFETY OF CAROTID ENDARTERECTOMY IN ASYMPTOMATIC PATIENTS: SYSTEMATIC REVIEW Response, NEUROLOGY, Vol: 86, Pages: 313-313, ISSN: 0028-3878
Qureshi MI, Gohel M, Wing L, et al., 2015, A study to evaluate patterns of superficial venous reflux in patients with primary chronic venous disease, PHLEBOLOGY, Vol: 30, Pages: 455-461, ISSN: 0268-3555
Munster AB, Franchini AJ, Qureshi MI, et al., 2015, Temporal trends in safety of carotid endarterectomy in asymptomatic patients, Neurology, Vol: 85, Pages: 365-372, ISSN: 0028-3878
Objective: To systematically review temporal changes in perioperative safety of carotid endarterectomy (CEA) in asymptomatic individuals in trial and registry studies.Methods: The MEDLINE and EMBASE databases were searched using the terms “carotid” and “endarterectomy” and “asymptomatic” from 1947 to August 23, 2014. Articles dealing with 50%–99% stenosis in asymptomatic individuals were included and low-volume studies were excluded. The primary endpoint was 30-day stroke or death and the secondary endpoint was 30-day all-cause mortality. Statistical analysis was performed using random-effects meta-regression for registry data and for trial data graphical interpretation alone was used.Results: Six trials (n = 4,431 procedures) and 47 community registries (n = 204,622 procedures) reported data between 1983 and 2013. Registry data showed a significant decrease in postoperative stroke or death incidence over the period 1991–2010, equivalent to a 6% average proportional annual reduction (95% credible interval [CrI] 4%–7%; p < 0.001). Considering postoperative all-cause mortality, registry data showed a significant 5% average proportional annual reduction (95% CrI 3%–9%; p < 0.001). Trial data showed a similar visual trend.Conclusions: CEA is safer than ever before and high-volume registry results closely mirror the results of trials. New benchmarks for CEA are a stroke or death risk of 1.2% and a mortality risk of 0.4%. This information will prove useful for quality improvement programs, for health care funders, and for those re-examining the long-term benefits of asymptomatic revascularization in future trials.
Mandavia R, Dharmarajah B, Qureshi MI, et al., 2015, The role of cost-effectiveness for vascular surgery service provision in the United Kingdom, JOURNAL OF VASCULAR SURGERY, Vol: 61, Pages: 1331-1339, ISSN: 0741-5214
Mandavia R, Qureshi MI, Dharmarajah B, et al., 2014, Safety of Carotid Intervention Following Thrombolysis in Acute Ischaemic Stroke, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 48, Pages: 505-512, ISSN: 1078-5884
Mandavia R, Qureshi MI, Davies AH, 2014, Safety of carotid surgery and intervention following thrombolysis in acute ischaemic stroke, Annual Meeting of the Society-of-Academic-and-Research-Surgery, Publisher: WILEY-BLACKWELL, Pages: 51-52, ISSN: 0007-1323
Shepherd AC, Qureshi MI, Davies AH, 2011, The Descending or Saphenocentric Theory of Superficial Venous Insufficiency., PHLEBOLOGIE-ANNALES VASCULAIRES, Vol: 64, Pages: 16-18
Shalhoub J, Qureshi M, Davies A, 2009, Supervised Exercise in Intermittent Claudication: A Sedentary Notion?, VASCULAR, Vol: 17, Pages: 66-73, ISSN: 1708-5381
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