Imperial College London
Alternate

Dr Mahim Irfan Qureshi

Faculty of Medicine, Department of Surgery & Cancer

Honorary Clinical Research Fellow
 
 
 
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Contact

 

mahim.qureshi

 
 
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Location

 

4 NorthCharing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Qureshi:2016:10.1177/1073858416673327,
author = {Qureshi, MI and Vorkas, PA and Coupland, AP and Jenkins, IH and Holmes, E and Davies, AH},
doi = {10.1177/1073858416673327},
journal = {Neuroscientist},
pages = {374--382},
title = {Lessons from metabonomics on the neurobiology of stroke},
url = {http://dx.doi.org/10.1177/1073858416673327},
volume = {23},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The application of metabonomic science to interrogate stroke permits the study of metabolite entities, small enough to cross the blood-brain barrier, that provide insight into neuronal dysfunction, and may serve as reservoirs of biomarker discovery. This systematic review examines the applicability of metabolic profiling in ischemic stroke research. Six human studies utilizing metabolic profiling to analyze biofluids from ischemic stroke patients have been included, employing 1H-NMR and/or mass spectrometry to analyze plasma, serum, and/or urine in a targeted or untargeted fashion. Three are diagnostic studies, and one investigates prognostic biomarkers of stroke recurrence following transient ischemic attack. Two studies focus on metabolic distinguishers of depression or cognitive impairment following stroke. Identified biomarkers from blood and urine predominantly relate to homocysteine and folate, branched chain amino acid, and lipid metabolism. Statistical models are well fitted and reproducible, with excellent validation outcomes, demonstrating the feasibility of metabolic profiling to study a complex disorder with multicausal pathology, such as stroke.
AU  - Qureshi,MI
AU  - Vorkas,PA
AU  - Coupland,AP
AU  - Jenkins,IH
AU  - Holmes,E
AU  - Davies,AH
DO  - 10.1177/1073858416673327
EP  - 382
PY  - 2016///
SN  - 1073-8584
SP  - 374
TI  - Lessons from metabonomics on the neurobiology of stroke
T2  - Neuroscientist
UR  - http://dx.doi.org/10.1177/1073858416673327
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000405380800006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/52758
VL  - 23
ER  -
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