Imperial College London

ProfessorMajidEzzati

Faculty of MedicineSchool of Public Health

Chair in Global Environmental Health
 
 
 
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Contact

 

+44 (0)20 7594 0767majid.ezzati Website

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Li:2019:10.1289/EHP4041,
author = {Li, S and Yang, M and Carter, E and Schauer, JJ and Yang, X and Ezzati, M and Goldberg, MS and Baumgartner, J},
doi = {10.1289/EHP4041},
journal = {Environ Health Perspect},
pages = {87004--87004},
title = {Exposure-Response Associations of Household Air Pollution and Buccal Cell Telomere Length in Women Using Biomass Stoves.},
url = {http://dx.doi.org/10.1289/EHP4041},
volume = {127},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - BACKGROUND: Telomere shortening is associated with early mortality and chronic disease. Recent studies indicate that environmental exposures, including urban and traffic-related air pollution, may shorten telomeres. Associations between exposure to household air pollution from solid fuel stoves and telomere length have not been evaluated. METHODS: Among 137 rural Chinese women using biomass stoves ([Formula: see text] of age), we measured 48-h personal exposures to fine particulate matter [PM [Formula: see text] in aerodynamic diameter ([Formula: see text])] and black carbon and collected oral DNA on up to three occasions over a period of 2.5 y. Relative telomere length (RTL) was quantified using a modified real-time polymerase chain reaction protocol. Mixed effects regression models were used to investigate the exposure-response associations between household air pollution and RTL, adjusting for key sociodemographic, behavioral, and environmental covariates. RESULTS: Women's daily exposures to air pollution ranged from [Formula: see text] for [Formula: see text] ([Formula: see text]) and [Formula: see text] for black carbon ([Formula: see text]). Natural cubic spline models indicated a mostly linear association between increased exposure to air pollution and shorter RTL, except at very high concentrations where there were few observations. We thus modeled the linear associations with all observations, excluding the highest 3% and 5% of exposures. In covariate-adjusted models, an interquartile range (IQR) increase in exposure to black carbon ([Formula: see text]) was associated with shorter RTL [all observations: [Formula: see text] (95% CI: [Formula: see text], [Formula: see text]); excluding highest 5% exposures: [Formula: see text] (95% CI: [Formula: see text], [Formula: see text])]. Further adjustment for outdoor temperature brought the estimates closer to zero [all observations: [Formula: see text] (95% CI: [Formula: see text], 0.06); excluding highest 5% expos
AU - Li,S
AU - Yang,M
AU - Carter,E
AU - Schauer,JJ
AU - Yang,X
AU - Ezzati,M
AU - Goldberg,MS
AU - Baumgartner,J
DO - 10.1289/EHP4041
EP - 87004
PY - 2019///
SP - 87004
TI - Exposure-Response Associations of Household Air Pollution and Buccal Cell Telomere Length in Women Using Biomass Stoves.
T2 - Environ Health Perspect
UR - http://dx.doi.org/10.1289/EHP4041
UR - https://www.ncbi.nlm.nih.gov/pubmed/31393791
VL - 127
ER -