Imperial College London


Faculty of MedicineSchool of Public Health

Chair in Global Environmental Health



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BibTex format

author = {Bennett, DA and Krishnamurthi, RV and Barker-Collo, S and Forouzanfar, MH and Naghavi, M and Connor, M and Lawes, CMM and Moran, AE and Anderson, LM and Roth, GA and Mensah, GA and Ezzati, M and Murray, CJL and Feigin, VL and Global, Burden of Diseases and Injuries and and, Risk Factors 2010 Study Stroke Expert Group},
doi = {10.1016/j.gheart.2014.01.001},
journal = {Glob Heart},
pages = {107--112},
title = {The global burden of ischemic stroke: findings of the GBD 2010 study.},
url = {},
volume = {9},
year = {2014}

RIS format (EndNote, RefMan)

AB - This study sought to summarize the findings of the GBD 2010 (Global Burden of Diseases, Injuries, and Risk Factors) study for ischemic stroke (IS) and to report the impact of tobacco smoking on IS burden in specific countries. The GBD 2010 searched multiple databases to identify relevant studies published between 1990 and 2010. The GBD 2010 analytical tools were used to calculate region-specific IS incidence, mortality, mortality-to-incidence ratio, and disability-adjusted life years (DALY) lost, including 95% uncertainty intervals (UI). In 2010, there were approximately 11,569,000 incident IS events (63% in low- and middle-income countries [LMIC]), approximately 2,835,000 deaths from IS (57% in LMIC), and approximately 39,389,000 DALY lost due to IS (64% in LMIC). From 1990 to 2010, there was a significant increase in global IS burden in terms of absolute number of people with incident IS (37% increase), deaths from IS (21% increase), and DALY lost due to IS (18% increase). Age-standardized IS incidence, DALY lost, mortality, and mortality-to-incidence ratios in high-income countries declined by about 13% (95% UI: 6% to 18%), 34% (95% UI: 16% to 36%), and 37% (95% UI: 19% to 39%), 21% (95% UI: 10% to 27%), respectively. However, in LMIC there was a modest 6% increase in the age-standardized incidence of IS (95% UI: -7% to 18%) despite modest reductions in mortality rates, DALY lost, and mortality-to-incidence ratios. There was considerable variability among country-specific estimates within broad GBD regions. China, Russia, and India were ranked highest in both 1990 and 2010 for IS deaths attributable to tobacco consumption. Although age-standardized IS mortality rates have declined over the last 2 decades, the absolute global burden of IS is increasing, with the bulk of DALY lost in LMIC. Tobacco consumption is an important modifiable risk factor for IS, and in both 1990 and 2010, the top ranked countries for IS deaths that could be attributed to tobacco cons
AU - Bennett,DA
AU - Krishnamurthi,RV
AU - Barker-Collo,S
AU - Forouzanfar,MH
AU - Naghavi,M
AU - Connor,M
AU - Lawes,CMM
AU - Moran,AE
AU - Anderson,LM
AU - Roth,GA
AU - Mensah,GA
AU - Ezzati,M
AU - Murray,CJL
AU - Feigin,VL
AU - Global,Burden of Diseases
AU - Injuries
AU - and,Risk Factors 2010 Study Stroke Expert Group
DO - 10.1016/j.gheart.2014.01.001
EP - 112
PY - 2014///
SP - 107
TI - The global burden of ischemic stroke: findings of the GBD 2010 study.
T2 - Glob Heart
UR -
UR -
VL - 9
ER -