Imperial College London

ProfessorMajidEzzati

Faculty of MedicineSchool of Public Health

Chair in Global Environmental Health
 
 
 
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Contact

 

+44 (0)20 7594 0767majid.ezzati Website

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wang:2016:10.1161/JAHA.115.002891,
author = {Wang, Q and Afshin, A and Yakoob, MY and Singh, GM and Rehm, CD and Khatibzadeh, S and Micha, R and Shi, P and Mozaffarian, D and Global, Burden of Diseases Nutrition and Chronic Diseases Expert Group NutriCoDE},
doi = {10.1161/JAHA.115.002891},
journal = {Journal of the American Heart Association},
title = {Impact of Nonoptimal Intakes of Saturated, Polyunsaturated, and Trans Fat on Global Burdens of Coronary Heart Disease.},
url = {http://dx.doi.org/10.1161/JAHA.115.002891},
volume = {5},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - BACKGROUND: Saturated fat (SFA), ω-6 (n-6) polyunsaturated fat (PUFA), and trans fat (TFA) influence risk of coronary heart disease (CHD), but attributable CHD mortalities by country, age, sex, and time are unclear. METHODS AND RESULTS: National intakes of SFA, n-6 PUFA, and TFA were estimated using a Bayesian hierarchical model based on country-specific dietary surveys; food availability data; and, for TFA, industry reports on fats/oils and packaged foods. Etiologic effects of dietary fats on CHD mortality were derived from meta-analyses of prospective cohorts and CHD mortality rates from the 2010 Global Burden of Diseases study. Absolute and proportional attributable CHD mortality were computed using a comparative risk assessment framework. In 2010, nonoptimal intakes of n-6 PUFA, SFA, and TFA were estimated to result in 711 800 (95% uncertainty interval [UI] 680 700-745 000), 250 900 (95% UI 236 900-265 800), and 537 200 (95% UI 517 600-557 000) CHD deaths per year worldwide, accounting for 10.3% (95% UI 9.9%-10.6%), 3.6%, (95% UI 3.5%-3.6%) and 7.7% (95% UI 7.6%-7.9%) of global CHD mortality. Tropical oil-consuming countries were estimated to have the highest proportional n-6 PUFA- and SFA-attributable CHD mortality, whereas Egypt, Pakistan, and Canada were estimated to have the highest proportional TFA-attributable CHD mortality. From 1990 to 2010 globally, the estimated proportional CHD mortality decreased by 9% for insufficient n-6 PUFA and by 21% for higher SFA, whereas it increased by 4% for higher TFA, with the latter driven by increases in low- and middle-income countries. CONCLUSIONS: Nonoptimal intakes of n-6 PUFA, TFA, and SFA each contribute to significant estimated CHD mortality, with important heterogeneity across countries that informs nation-specific clinical, public health, and policy priorities.
AU - Wang,Q
AU - Afshin,A
AU - Yakoob,MY
AU - Singh,GM
AU - Rehm,CD
AU - Khatibzadeh,S
AU - Micha,R
AU - Shi,P
AU - Mozaffarian,D
AU - Global,Burden of Diseases Nutrition and Chronic Diseases Expert Group NutriCoDE
DO - 10.1161/JAHA.115.002891
PY - 2016///
SN - 2047-9980
TI - Impact of Nonoptimal Intakes of Saturated, Polyunsaturated, and Trans Fat on Global Burdens of Coronary Heart Disease.
T2 - Journal of the American Heart Association
UR - http://dx.doi.org/10.1161/JAHA.115.002891
UR - http://hdl.handle.net/10044/1/56058
VL - 5
ER -