Imperial College London

ProfessorMajidEzzati

Faculty of MedicineSchool of Public Health

Chair in Global Environmental Health
 
 
 
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Contact

 

+44 (0)20 7594 0767majid.ezzati Website

 
 
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Location

 

Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pearson-Stuttard:2017:10.1016/S2213-8587(17)30366-2,
author = {Pearson-Stuttard, J and Zhou, B and Kontis, V and Bentham, J and Gunter, M and Ezzati, M},
doi = {10.1016/S2213-8587(17)30366-2},
journal = {Lancet Diabetes and Endocrinology},
pages = {95--104},
title = {Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessment},
url = {http://dx.doi.org/10.1016/S2213-8587(17)30366-2},
volume = {6},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - BackgroundDiabetes and high body-mass index (BMI) are associated with increased risk of several cancers, and are increasing in prevalence in most countries. We estimated the cancer incidence attributable to diabetes and high BMI as individual risk factors and in combination, by country and sex.MethodsWe estimated population attributable fractions for 12 cancers by age and sex for 175 countries in 2012. We defined high BMI as a BMI greater than or equal to 25 kg/m2. We used comprehensive prevalence estimates of diabetes and BMI categories in 2002, assuming a 10-year lag between exposure to diabetes or high BMI and incidence of cancer, combined with relative risks from published estimates, to quantify contribution of diabetes and high BMI to site-specific cancers, individually and combined as independent risk factors and in a conservative scenario in which we assumed full overlap of risk of diabetes and high BMI. We then used GLOBOCAN cancer incidence data to estimate the number of cancer cases attributable to the two risk factors. We also estimated the number of cancer cases in 2012 that were attributable to increases in the prevalence of diabetes and high BMI from 1980 to 2002. All analyses were done at individual country level and grouped by region for reporting.FindingsWe estimated that 5·6% of all incident cancers in 2012 were attributable to the combined effects of diabetes and high BMI as independent risk factors, corresponding to 792600 new cases. 187600 (24·5%) of 766000 cases of liver cancer and 121700 (38·4%) of 317000 cases of endometrial cancer were attributable to these risk factors. In the conservative scenario, about 4·5% (626900 new cases) of all incident cancers assessed were attributable to diabetes and high BMI combined. Individually, high BMI (544300 cases) was responsible for twice as many cancer cases as diabetes (280100 cases). 26·1% of diabetes-related cancers (equating to 77000 new cases) and 31&mid
AU - Pearson-Stuttard,J
AU - Zhou,B
AU - Kontis,V
AU - Bentham,J
AU - Gunter,M
AU - Ezzati,M
DO - 10.1016/S2213-8587(17)30366-2
EP - 104
PY - 2017///
SN - 2213-8595
SP - 95
TI - Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessment
T2 - Lancet Diabetes and Endocrinology
UR - http://dx.doi.org/10.1016/S2213-8587(17)30366-2
UR - http://hdl.handle.net/10044/1/52015
VL - 6
ER -