Imperial College London
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ProfessorMajidEzzati

Faculty of Medicine, School of Public Health

Chair in Global Environmental Health
 
 
 
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Contact

 

majid.ezzati Website

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Arden:2019,
author = {Arden, Pope C and Lefler, JS and Ezzati, M and Higbee, JD and Marshall, JD and Kim, SY and Bechle, M and Gilliat, KS and Vernon, SE and Robinson, AL and Burnett, RT},
journal = {Environmental Health Perspectives},
pages = {077007--1--077007--9},
title = {Mortality risk and fine particulate air pollution in a large, representative cohort of U.S. adults},
url = {https://ehp.niehs.nih.gov/doi/10.1289/EHP4438},
volume = {127},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:  Evidence indicates that air pollution contributes to cardiopulmonary mortality.  There is ongoing debate regarding the size and shape of the pollution-mortality exposure-response relationship.  There are also growing appeals for estimates of pollution-mortality relationships that use public data and are based on large, representative study cohorts.Objectives:  Evaluate fine particulate matter air pollution (PM2.5) and mortality using a large cohort that is representative of the U.S. population and is based on public data.  Additional objectives include exploring model sensitivity, evaluating relative effects across selected subgroups, and assessing the shape of the PM2.5-mortality relationship.Methods:  National Health Interview Surveys (1986-2014), with mortality linkage through 2015, were used to create a cohort of 1,599,329 U.S. adults and a sub-cohort with information on smoking and BMI of 635,539 adults.  Data were linked with modeled ambient PM2.5 at census tracts.  Cox Proportional Hazards models estimated PM2.5-mortality hazard ratios for all-cause and specific causes of death controlling for individual risk factors and regional and urban versus rural differences.  Sensitivity and subgroup analyses were conducted and the shape of the PM2.5-mortality relationship was explored.Results:  Estimated mortality hazard ratios, per 10 µg/m3 long-term exposure to PM2.5, were 1.12 (95% CI=1.08–1.15) for all-cause mortality, 1.23 (1.17–1.29) for cardiopulmonary mortality, and 1.12 (1.00 – 1.26) for lung cancer mortality.  In general, PM2.5-mortality associations were consistently positive for all-cause and cardiopulmonary across key modeling choices and across sub-groups of sex, age, race-ethnicity, income, education levels, and geographic regions.Discussion:  This large, nationwide, representative cohort of U.S. adults provides robust evidence that long-term PM2.5 exposure contributes to cardiopulmonary mortality risk.  The ubiquito
AU  - Arden,Pope C
AU  - Lefler,JS
AU  - Ezzati,M
AU  - Higbee,JD
AU  - Marshall,JD
AU  - Kim,SY
AU  - Bechle,M
AU  - Gilliat,KS
AU  - Vernon,SE
AU  - Robinson,AL
AU  - Burnett,RT
EP  - 1
PY  - 2019///
SN  - 0091-6765
SP  - 077007
TI  - Mortality risk and fine particulate air pollution in a large, representative cohort of U.S. adults
T2  - Environmental Health Perspectives
UR  - https://ehp.niehs.nih.gov/doi/10.1289/EHP4438
UR  - http://hdl.handle.net/10044/1/70686
VL  - 127
ER  -
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