Imperial College London
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ProfessorMajidEzzati

Faculty of Medicine, School of Public Health

Chair in Global Environmental Health
 
 
 
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majid.ezzati Website

 
 
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Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Carrillo-Larco:2021:10.1016/j.lana.2021.100068,
author = {Carrillo-Larco, RM and Stern, D and Hambleton, IR and Hennis, A and Cesare, MD and Lotufo, P and Ferreccio, C and Irazola, V and Perel, P and Gregg, EW and Miranda, JJ and Ezzati, M and Danaei, G and Aguilar-Salinas, CA and Alvarez-Váz, R and Amadio, MB and Baccino, C and Bambs, C and Bastos, JL and Beckles, G and Bernabe-Ortiz, A and Bernardo, CDO and Bloch, KV and Blümel, JE and Boggia, JG and Borges, PK and Bravo, M and Brenes-Camacho, G and Carbajal, HA and Rascon, MSC and Ceballos, BH and Colpani, V and Cooper, JA and Cortes, S and Cortes-Valencia, A and Cunha, RS and d'Orsi, E and Dow, WH and Espeche, WG and Fuchs, FD and Fuchs, SC and Gimeno, SGA and Gomez-Velasco, D and Gonzalez-Chica, DA and Gonzalez-Villalpando, C and Gonzalez-Villalpando, M-E and Grazioli, G and Guerra, RO and Gutierrez, L and Herkenhoff, FL and Horimoto, ARVR and Huidobro, A and Koch, E and Lajous, M and Lima-Costa, MF and Lopez-Ridaura, R and Maciel, ACC and Manrique-Espinoza, BS and Marques, LP and Mill, },
doi = {10.1016/j.lana.2021.100068},
journal = {The Lancet Regional Health - Americas},
pages = {1--12},
title = {Impact of common cardio-metabolic risk factors on fatal and non-fatal cardiovascular disease in Latin America and the Caribbean: an individual-level pooled analysis of 31 cohort studies},
url = {http://dx.doi.org/10.1016/j.lana.2021.100068},
volume = {4},
year = {2021}
}
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TY  - JOUR
AB  - BackgroundEstimates of the burden of cardio-metabolic risk factors in Latin America and the Caribbean (LAC) rely on relative risks (RRs) from non-LAC countries. Whether these RRs apply to LAC remains unknown.MethodsWe pooled LAC cohorts. We estimated RRs per unit of exposure to body mass index (BMI), systolic blood pressure (SBP), fasting plasma glucose (FPG), total cholesterol (TC) and non-HDL cholesterol on fatal (31 cohorts, n=168,287) and non-fatal (13 cohorts, n=27,554) cardiovascular diseases, adjusting for regression dilution bias. We used these RRs and national data on mean risk factor levels to estimate the number of cardiovascular deaths attributable to non-optimal levels of each risk factor.ResultsOur RRs for SBP, FPG and TC were like those observed in cohorts conducted in high-income countries; however, for BMI, our RRs were consistently smaller in people below 75 years of age. Across risk factors, we observed smaller RRs among older ages. Non-optimal SBP was responsible for the largest number of attributable cardiovascular deaths ranging from 38 per 100,000 women and 54 men in Peru, to 261 (Dominica, women) and 282 (Guyana, men). For non-HDL cholesterol, the lowest attributable rate was for women in Peru (21) and men in Guatemala (25), and the largest in men (158) and women (142) from Guyana.InterpretationRRs for BMI from studies conducted in high-income countries may overestimate disease burden metrics in LAC; conversely, RRs for SBP, FPG and TC from LAC cohorts are similar to those estimated from cohorts in high-income countries.FundingWellcome Trust (214185/Z/18/Z)
AU  - Carrillo-Larco,RM
AU  - Stern,D
AU  - Hambleton,IR
AU  - Hennis,A
AU  - Cesare,MD
AU  - Lotufo,P
AU  - Ferreccio,C
AU  - Irazola,V
AU  - Perel,P
AU  - Gregg,EW
AU  - Miranda,JJ
AU  - Ezzati,M
AU  - Danaei,G
AU  - Aguilar-Salinas,CA
AU  - Alvarez-Váz,R
AU  - Amadio,MB
AU  - Baccino,C
AU  - Bambs,C
AU  - Bastos,JL
AU  - Beckles,G
AU  - Bernabe-Ortiz,A
AU  - Bernardo,CDO
AU  - Bloch,KV
AU  - Blümel,JE
AU  - Boggia,JG
AU  - Borges,PK
AU  - Bravo,M
AU  - Brenes-Camacho,G
AU  - Carbajal,HA
AU  - Rascon,MSC
AU  - Ceballos,BH
AU  - Colpani,V
AU  - Cooper,JA
AU  - Cortes,S
AU  - Cortes-Valencia,A
AU  - Cunha,RS
AU  - d'Orsi,E
AU  - Dow,WH
AU  - Espeche,WG
AU  - Fuchs,FD
AU  - Fuchs,SC
AU  - Gimeno,SGA
AU  - Gomez-Velasco,D
AU  - Gonzalez-Chica,DA
AU  - Gonzalez-Villalpando,C
AU  - Gonzalez-Villalpando,M-E
AU  - Grazioli,G
AU  - Guerra,RO
AU  - Gutierrez,L
AU  - Herkenhoff,FL
AU  - Horimoto,ARVR
AU  - Huidobro,A
AU  - Koch,E
AU  - Lajous,M
AU  - Lima-Costa,MF
AU  - Lopez-Ridaura,R
AU  - Maciel,ACC
AU  - Manrique-Espinoza,BS
AU  - Marques,LP
AU  - Mill,JG
AU  - Moreira,LB
AU  - Muñoz,OM
AU  - Ono,LM
AU  - Oppermann,K
AU  - Paiva,KM
AU  - Peixoto,SV
AU  - Pereira,AC
AU  - Peres,KG
AU  - Peres,MA
AU  - Ramírez-Palacios,P
AU  - Rech,CR
AU  - Rivera-Paredez,B
AU  - Rodriguez,NI
AU  - Rojas-Martinez,R
AU  - Rosero-Bixby,L
AU  - Rubinstein,A
AU  - Ruiz-Morales,A
AU  - Salazar,MR
AU  - Salinas-Rodriguez,A
AU  - Salmerón,J
AU  - Sanchez,RA
AU  - Silva,NAS
AU  - Silva,TLN
AU  - Smeeth,L
AU  - Spritzer,PM
AU  - Tartaglione,F
AU  - Tartaglione,J
AU  - Velázquez-Cruz,R
DO  - 10.1016/j.lana.2021.100068
EP  - 12
PY  - 2021///
SN  - 2667-193X
SP  - 1
TI  - Impact of common cardio-metabolic risk factors on fatal and non-fatal cardiovascular disease in Latin America and the Caribbean: an individual-level pooled analysis of 31 cohort studies
T2  - The Lancet Regional Health - Americas
UR  - http://dx.doi.org/10.1016/j.lana.2021.100068
UR  - https://www.sciencedirect.com/science/article/pii/S2667193X21000648?via%3Dihub
UR  - http://hdl.handle.net/10044/1/98218
VL  - 4
ER  -
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