8 results found
Dong R, Liu R, Gaffney P, et al., 2019, Sequence-defined multifunctional polyethers via liquid-phase synthesis with molecular sieving, Nature Chemistry, Vol: 11, Pages: 136-145, ISSN: 1755-4330
Synthetic chemists have devoted tremendous effort towards the production of precision synthetic polymers with defined sequences and specific functions. However, the creation of a general technology that enables precise control over monomer sequence, with efficient isolation of the target polymers, is highly challenging. Here, we report a robust strategy for the production of sequence-defined synthetic polymers through a combination of liquid-phase synthesis and selective molecular sieving. The polymer is assembled in solution with real-time monitoring to ensure couplings proceed to completion, on a three-armed star-shaped macromolecule to maximize efficiency during the molecular sieving process. This approach is applied to the construction of sequence-defined polyethers, with side-arms at precisely defined locations that can undergo site-selective modification after polymerization. Using this versatile strategy, we have introduced structural and functional diversity into sequence-defined polyethers, unlocking their potential for real-life applications in nanotechnology, healthcare and information storage.
Dong R, Liu R, Gaffney PRJ, et al., 2019, Author Correction: Sequence-defined multifunctional polyethers via liquid-phase synthesis with molecular sieving, Nature Chemistry, Vol: 11, Pages: 184-184, ISSN: 1755-4330
Correction to: Nature Chemistry https://doi.org/10.1038/s41557-018-0169-6, published online 3 December 2018.
Schaepertoens M, Didaskalou C, Kim JF, et al., 2016, Solvent recycle with imperfect membranes: A semi-continuous workaround for diafiltration, Journal of Membrane Science, Vol: 514, Pages: 646-658, ISSN: 1873-3123
For separation of a two-component mixture, a three-stage organic solvent nanofiltration (OSN) process is presented which comprises of a two-stage membrane cascade for separation with a third membrane stage added for integrated solvent recovery, i.e. solvent recycling. The two-stage cascade allows for increased separation selectivity whilst the integrated solvent recovery stage mitigates the otherwise large solvent consumption of the purification. This work explores the effect of washing the solvent recovery unit at intervals in order to attain high product purities with imperfect solvent recovery membranes possessing less than 100% rejection of the impurity. This operation attains a purity of 98.7% through semi-continuous operation with two washes of the solvent recovery stage, even when imperfect membranes are used in a closed-loop set-up. This contrasts favourably with the 83.0% maximum purity achievable in a similar set-up with a single continuous run. The process achieves slightly lower (−0.7%) yield of around 98.2% compared to a continuously operated process without solvent recovery but consumes approx. 85% less solvent (theoretical analysis suggests up to 96% reduction is possible). 9 different membranes, both commercial (GMT, Novamem, SolSep) and in-house fabricated, are screened and tested on a separation challenge associated with the synthesis of macrocycles – amongst the membrane materials are polyimide (PI), polybenzimidazole (PBI) and, polyetheretherketone (PEEK).
Kim JF, Szekely G, Schaepertoens M, et al., 2014, In Situ Solvent Recovery by Organic Solvent Nanofiltration, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, Vol: 2, Pages: 2371-2379, ISSN: 2168-0485
Szekely G, Schaepertoens M, Gaffney PRJ, et al., 2014, Beyond PEG2000: Synthesis and Functionalisation of Monodisperse PEGylated Homostars and Clickable Bivalent Polyethyleneglycols, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 20, Pages: 10038-10051, ISSN: 0947-6539
Szekely G, Schaepertoens M, Gaffney PRJ, et al., 2014, Iterative synthesis of monodisperse PEG homostars and linear heterobifunctional PEG, POLYMER CHEMISTRY, Vol: 5, Pages: 694-697, ISSN: 1759-9954
Khoo JY, Shah UV, Schaepertoens M, et al., 2013, Process-induced phase transformation of carbamazepine dihydrate to its polymorphic anhydrates, POWDER TECHNOLOGY, Vol: 236, Pages: 114-121, ISSN: 0032-5910
Parambil JV, Schaepertoens M, Williams DR, et al., 2011, Effects of Oscillatory Flow on the Nucleation and Crystallization of Insulin, CRYSTAL GROWTH & DESIGN, Vol: 11, Pages: 4353-4359, ISSN: 1528-7483
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