Imperial College London
Portrait Picture

DrMariaPapathanasiou

Faculty of Engineering, Department of Chemical Engineering

Senior Lecturer
 
 
 
//

Contact

 

maria.papathanasiou11

 
 
//

Location

 

RODH.501DRoderic Hill BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@inbook{Bernardi:2021:10.1016/B978-0-323-88506-5.50309-0,
author = {Bernardi, A and Papathanasiou, M and Lakelin, MW and Shah, N},
booktitle = {Computer Aided Chemical Engineering},
doi = {10.1016/B978-0-323-88506-5.50309-0},
pages = {1997--2002},
title = {Assessment of intermediate storage and distribution nodes in personalised medicine},
url = {http://dx.doi.org/10.1016/B978-0-323-88506-5.50309-0},
year = {2021}
}
Download

RIS format (EndNote, RefMan)

TY  - CHAP
AB  - Chimeric Antigen Receptor (CAR)-T cell therapies are a type of patient-specific cell immunotherapy demonstrating promising results in the treatment of aggressive blood cancer types. CAR-T cells follow a 1:1 business model, translating into manufacturing lines and distribution nodes being exclusive to the production of a single therapy, hindering volumetric scale up. In this work, we address manufacturing capacity bottlenecks via a Mixed Integer Linear Programming (MILP) model. The proposed formulation focuses on the design of candidate supply chain network configurations under different demand scenarios. We investigate the effect of an intermediate storage option upstream of the network as means of: (a) debottlenecking manufacturing lines and (b) increasing facility utilisation. In this setting, we assess cost-effectiveness and flexibility of a decentralised supply chain and we evaluate network performance with respect to two key performance indicators (KPIs): (a) average production cost and (b) average response treatment time. The trade-off between cost-efficiency and responsiveness is examined and discussed.
AU  - Bernardi,A
AU  - Papathanasiou,M
AU  - Lakelin,MW
AU  - Shah,N
DO  - 10.1016/B978-0-323-88506-5.50309-0
EP  - 2002
PY  - 2021///
SP  - 1997
TI  - Assessment of intermediate storage and distribution nodes in personalised medicine
T1  - Computer Aided Chemical Engineering
UR  - http://dx.doi.org/10.1016/B978-0-323-88506-5.50309-0
ER  -
Download