Imperial College London
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DrMariaPapathanasiou

Faculty of Engineering, Department of Chemical Engineering

Senior Lecturer
 
 
 
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Contact

 

maria.papathanasiou11

 
 
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Location

 

RODH.501DRoderic Hill BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Kis:2022:10.1016/B978-0-323-85159-6.50361-4,
author = {Kis, Z and Tak, K and Ibrahim, D and Daniel, S and van, de Berg D and Papathanasiou, MM and Chachuat, B and Kontoravdi, C and Shah, N},
booktitle = {Computer Aided Chemical Engineering},
doi = {10.1016/B978-0-323-85159-6.50361-4},
pages = {2167--2172},
title = {Quality by design and techno-economic modelling of RNA vaccine production for pandemic-response},
url = {http://dx.doi.org/10.1016/B978-0-323-85159-6.50361-4},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - Vaccine production platform technologies have played a crucial role in rapidly developing and manufacturing vaccines during the COVID-19 pandemic. The role of disease agnostic platform technologies, such as the adenovirus-vectored (AVV), messenger RNA (mRNA), and the newer self-amplifying RNA (saRNA) vaccine platforms is expected to further increase in the future. Here we present modelling tools that can be used to aid the rapid development and mass-production of vaccines produced with these platform technologies. The impact of key design and operational uncertainties on the productivity and cost performance of these vaccine platforms is evaluated using techno-economic modelling and variance-based global sensitivity analysis. Furthermore, the use of the quality by digital design framework and techno-economic modelling for supporting the rapid development and improving the performance of these vaccine production technologies is also illustrated.
AU  - Kis,Z
AU  - Tak,K
AU  - Ibrahim,D
AU  - Daniel,S
AU  - van,de Berg D
AU  - Papathanasiou,MM
AU  - Chachuat,B
AU  - Kontoravdi,C
AU  - Shah,N
DO  - 10.1016/B978-0-323-85159-6.50361-4
EP  - 2172
PY  - 2022///
SP  - 2167
TI  - Quality by design and techno-economic modelling of RNA vaccine production for pandemic-response
T1  - Computer Aided Chemical Engineering
UR  - http://dx.doi.org/10.1016/B978-0-323-85159-6.50361-4
ER  -
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