Publications
465 results found
Curry RA, Gelson E, Swan L, et al., 2014, Marfan syndrome and pregnancy: maternal and neonatal outcomes, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 121, Pages: 610-617, ISSN: 1470-0328
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- Citations: 42
Yulia A, Georgiou EX, Das A, et al., 2014, Enhancement of Anti-Inflammatory Effect by the Combination of Progesterone and cAMP on IL-1b-Stimulated Human Myometrial Cells., REPRODUCTIVE SCIENCES, Vol: 21, Pages: 111A-111A, ISSN: 1933-7191
Nawathe A, Hye KS, Savvidou M, et al., 2014, Placental Expression of IGFs and Their Binding Proteins in Pregnancies Affected by Growth Disorders, Diabetes and Obesity., REPRODUCTIVE SCIENCES, Vol: 21, Pages: 294A-294A, ISSN: 1933-7191
Mitsuya K, Singh N, Sooranna SR, et al., 2014, Alterations to DNA Methylome Identified in Myometrium with Idiopathic Preterm Labor, REPRODUCTIVE SCIENCES, Vol: 21, Pages: 96A-97A, ISSN: 1933-7191
Waldorf KA, Sooranna S, Gravett M, et al., 2014, Acute Uterine Stretch Induces an Inflammatory "Pulse" in Amniotic Fluid and Maternal Plasma Followed by Preterm Labor in Nonhuman Primates, REPRODUCTIVE SCIENCES, Vol: 21, Pages: 96A-96A, ISSN: 1933-7191
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- Citations: 2
Georgiou EX, Edey LF, Lei K, et al., 2014, RU486-Induced Preterm Labour: A Shifting Paradigm?, REPRODUCTIVE SCIENCES, Vol: 21, Pages: 141A-142A, ISSN: 1933-7191
Herbert BR, Yulia A, Sooranna SR, et al., 2014, Phosphodiesterase Inhibition in Combination with Progesterone Treatment Can Inhibit Inflammation-Induced Preterm Labour in Mice., REPRODUCTIVE SCIENCES, Vol: 21, Pages: 143A-143A, ISSN: 1933-7191
Yulia A, Singh N, Lei K, et al., 2014, Molecular Markers of cAMP Related Genes during Gestation and Parturition in Human Myometrium, REPRODUCTIVE SCIENCES, Vol: 21, Pages: 347A-347A, ISSN: 1933-7191
Singh N, Yulia A, Lei K, et al., 2014, The Molecular Expression of Different Phenotype-Specific Causes of Preterm Labour in Comparison to Term Labour, REPRODUCTIVE SCIENCES, Vol: 21, Pages: 340A-341A, ISSN: 1933-7191
Nawathe A, Hye KS, Savvidou M, et al., 2014, Effect of Adiponectin on IL-6 and COX-2 Expression in Term Placental Explants, REPRODUCTIVE SCIENCES, Vol: 21, Pages: 370A-370A, ISSN: 1933-7191
Zheng X, Sooranna SR, Ma D, et al., 2014, Acute Expression of Cytokines in the Brain and Long Term Neurocognitive Outcome in a Perinatal Asphyxia Mouse Model, REPRODUCTIVE SCIENCES, Vol: 21, Pages: 376A-377A, ISSN: 1933-7191
Zollner J, Ke H-Y, Sooranna SR, et al., 2014, The Expression of the Sodium Potassium ATPases in Cardiac Myocytes in a Guinea Pig Model of Transaortic Constriction, REPRODUCTIVE SCIENCES, Vol: 21, Pages: 384A-384A, ISSN: 1933-7191
Lei K, Chen L, Georgiou EX, et al., 2014, Progesterone Antagonizes IL-1b-Induced COX-2 Expression by Inhibiting AP-1 in Human Myometrial Cells, REPRODUCTIVE SCIENCES, Vol: 21, Pages: 243A-244A, ISSN: 1933-7191
Das A, Lei K, Sooranna SR, et al., 2014, Mechanical Stretch of Human Myometrial Cells in the Absence and Presence of Specific FAK Inhibition., REPRODUCTIVE SCIENCES, Vol: 21, Pages: 139A-140A, ISSN: 1933-7191
Lai PF, Tribe RM, Johnson MR, 2014, Prolonged Exposure to cAMP Enhancers Increases Pregnant Human Myometrium Contractility and Alters Contraction-Associated Protein Expression, 61st Annual Scientific Meeting of the Society-for-Gynecologic-Investigation (SGI), Publisher: SAGE PUBLICATIONS INC, Pages: 242A-243A, ISSN: 1933-7191
Karda R, Delhove JMKM, Buckley SMK, et al., 2014, Somatic Transgenesis of the Central Nervous System for Disease Modelling and Treatment, REPRODUCTIVE SCIENCES, Vol: 21, Pages: 276A-277A, ISSN: 1933-7191
Howe L, Wang Z, Edey LF, et al., 2014, Modulation of Haemodynamic Adaptations in Pregnancy by Progesterone and Nitric Oxide, REPRODUCTIVE SCIENCES, Vol: 21, Pages: 237A-237A, ISSN: 1933-7191
Edey LF, O'Dea KP, Takata M, et al., 2014, Systemic and Local Trafficking of Myeloid Leucocytes in Late Stage Murine Pregnancy., REPRODUCTIVE SCIENCES, Vol: 21, Pages: 141A-141A, ISSN: 1933-7191
Khanjani S, Kandola MK, Lee YS, et al., 2014, EP2 Receptor Activates Dual G Protein Signalling Pathways That Mediate Contrasting Pro- and Anti-Labor Responses in Term Pregnant Human Myometrium, REPRODUCTIVE SCIENCES, Vol: 21, Pages: 124A-124A, ISSN: 1933-7191
Shah N, Imami N, Johnson M, 2014, Antigenic Readiness, Enhanced Immune Response and Modified Tolerant Phenotypes Follows Flu Vaccination in Pregnancy, REPRODUCTIVE SCIENCES, Vol: 21, Pages: 411A-411A, ISSN: 1933-7191
Ruys TPE, Roos-Hesselink JW, Hall R, et al., 2014, Heart failure in pregnant women with cardiac disease: data from the ROPAC, HEART, Vol: 100, Pages: 231-U116, ISSN: 1355-6037
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- Citations: 140
Chen L, Lei K, Malawana J, et al., 2014, Cyclic AMP enhances progesterone action in human myometrial cells, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 382, Pages: 334-343, ISSN: 0303-7207
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- Citations: 18
Migale R, MacIntyre DA, Lee YS, et al., 2013, TLR4-mediated activation of AP-1 drives the expression of labour associated genes in the mouse myometrium, RCOG Annual Academic Meeting 2013
Karda R, Delhove JMKM, Buckley SMK, et al., 2013, Somatic transgenesis of the central nervous system for disease modelling and treatment, Collaborative Congress of the European-Society-for-Gene-and-Cell-Therapy and the Spanish-Society-for-Gene-and-Cell-Therapy, Publisher: MARY ANN LIEBERT, INC, Pages: A117-A117, ISSN: 1043-0342
Kandola MK, Sykes L, Lee YS, et al., 2013, EP2 Receptor Activates Dual G Protein Signaling Pathways that Mediate Contrasting Proinflammatory and Relaxatory Responses in Term Pregnant Human Myometrium, Endocrinology, Vol: Epub ahead of print
Prostaglandin (PG) E2 (PGE2) plays a central role in the regulation of smooth muscle contractions. Classically, PGE2 stimulates contractions via EP1 and EP3 receptors, whereas EP2 and EP4 maintain quiescence. Labor involves a change from myometrial quiescence to contractions with a shift from anti- to proinflammatory pathways. EP2, a Gαs-coupled receptor, is known to mediate its actions via cAMP signaling. However, we have recently shown that EP2 also activates the proinflammatory PG G/H synthase-2 (PGHS-2). Here, we identify the mechanism underlying the ability of EP2 to maintain uterine quiescence and activate a proinflammatory/prolabor response in term-pregnant human myometrium. Human myometrial biopsies for in vivo and in vitro studies were taken at cesarean section at term, before or after the onset of labor. Activation of EP2 increased intracellular levels of cAMP and reduced contractility. Contrastingly, EP2 stimulation increased levels of PGHS-2, PG synthase mPGES-1, and PGE2. This was entirely dependent on EP2-mediated activation of calcium signaling. Both calcium signaling and up-regulation of PGHS-2 were insensitive to the Gαi inhibitor pertussis toxin but inhibited by siRNA knockdown of Gαq/11. There were no differences in EP2 mRNA or protein levels between upper or lower segment myometrium or between pre- and postlabor myometrium. However, in myocytes taken after the onset of labor, cAMP signaling was markedly attenuated, whereas activation of calcium and PGHS-2 was preserved. Overall, the dual coupling of EP2 to Gαs-cAMP and Gαq/11-calcium pathways underlies its ability to mediate contrasting functions in term pregnancy and the “switching” to a prolabor receptor.
Roos-Hesselink JW, Johnson MR, 2013, Does fertility therapy hamper cardiovascular outcome?, J Am Coll Cardiol, Vol: 62, Pages: 1713-1714
Johnson M, Gatzoulis M, Roos-Hesselink J, 2013, Pregnancy and heart disease: Time for a randomized controlled trial, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 168, Pages: 3149-3151, ISSN: 0167-5273
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- Citations: 4
Ruys TPE, Johnson MR, Roos-Hesselink JW, 2013, Pregnancy and heart disease, Essential Cardiology: Principles and Practice, Pages: 655-667, ISBN: 9781461467045
Although women with heart disease are rare in the obstetric population, they are the main cause of maternal mortality and morbidity. During pregnancy large hemodynamic changes take place. In developing countries, rheumatic heart disease is still a major problem. While in the developed countries congenital heart disease is most often encountered, but acquired heart diseases such as aortic dissection and acute coronary syndrome cause the highest maternal mortality rates. Specific Cardiac Disease. Congenital cardiology covers a wide spectrum of heart diseases, ranging from simple shunts lesions to very rare and complex disorders. Patients with unrepaired lesions, cyanotic lesions, diminished systemic ventricular function, complex congenital heart disease, left ventricular outflow tract obstruction, and mechanical valves are at highest risk of complications during pregnancy. Although other conditions such as peripartum cardiomyopathy, Marfan syndrome, and pulmonary arterial hypertension are also associated with high maternal mortality and compromised pregnancy outcome. Management. Pre-pregnancy evaluation should focus on identifying and quantifying the risk to the mother and on the outcomes of the potential pregnancy. Current medication use should be discussed and if necessary changed, since some medication may be harmful for the unborn child. The most common cardiac complications in pregnant patients with heart disease are arrhythmias and heart failure. The balance between maternal and fetal outcome should always be considered in treatment choices and should be discussed with the future parents. Generally, vaginal delivery is preferred in women with adequate cardiac output. Neonatal outcome is strongly correlated with maternal outcome.
Karda R, Delhove J, Buckley S, et al., 2013, Somatic transgenesis of the central nervous system for disease modelling and treatment, Conference of the British-Society-for-Gene-and-Cell-Therapy (BSGCT), Publisher: MARY ANN LIEBERT INC, Pages: A32-A32, ISSN: 1043-0342
Zoellner J, Curry R, Johnson M, 2013, The contribution of heart disease to maternal mortality, CURRENT OPINION IN OBSTETRICS & GYNECOLOGY, Vol: 25, Pages: 91-97, ISSN: 1040-872X
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- Citations: 13
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